Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(10)
Published: Nov. 27, 2023
Abstract
Precision
medicine
requires
precise
regulation
of
drugs
in
terms
time,
space,
and
dosage.
Exogenous
control
systems,
such
as
electrical
responsiveness,
have
made
great
progress.
However,
wearable
or
implantable
controlled
drug
release
devices
still
face
major
challenges
due
to
limitations
including
limited
battery
life,
large
size,
fixed
power
supply.
To
overcome
these
limitations,
the
fabrication
autonomous
is
available
endure
extended
periods
without
reliance
on
external
sources.
As
a
promising
strategy,
nanogenerators
(NGs)
turn
body
mechanical
energy
into
electricity,
powering
long‐term
release.
In
this
review,
current
status
delivery
systems
(DDS)
briefly
outlined
importance
self‐driven
emphasized.
The
main
types
operational
mechanisms
various
are
introduced.
This
review
also
focuses
summarizing
latest
progress
self‐powered
based
(NG‐based
CDRs).
Additionally,
their
applications
field
introduced
detail.
Finally,
existing
future
trends
NG‐based
CDRs
discussed
from
perspectives
clinical
needs
practical
translation.
Journal of Controlled Release,
Journal Year:
2023,
Volume and Issue:
354, P. 394 - 416
Published: Jan. 18, 2023
Bacterial
biofilms
are
highly
protected
surface
attached
communities
of
bacteria
that
typically
cause
chronic
infections.
To
address
their
recalcitrance
to
antibiotics
and
minimise
side
effects
current
therapies,
smart
drug
carriers
being
explored
as
promising
platforms
for
antimicrobials.
Herein,
we
briefly
summarize
recent
efforts
considerations
have
been
applied
in
the
design
these
carriers.
We
guide
readers
on
a
journey
how
they
can
leverage
inherent
biofilm
microenvironment,
external
stimuli,
or
combine
both
types
stimuli
predictable
manner.
The
specific
carrier
features
responsible
'on-demand'
properties
detailed
impact
antibiofilm
property
further
discussed.
Moreover,
an
analysis
such
release
profiles
is
provided.
Since
nanotechnology
represents
significant
slice
delivery
pie,
some
insights
potential
toxicity
also
depicted.
hope
this
review
inspires
researchers
use
knowledge
creativity
responsive
systems
eradicate
Current Medical Research and Opinion,
Journal Year:
2024,
Volume and Issue:
40(11), P. 1943 - 1961
Published: Oct. 16, 2024
The
development
of
therapies
followed
a
generalized
approach
for
long
time,
assuming
that
single
treatment
could
effectively
address
various
patient
populations.
However,
recent
breakthroughs
have
revealed
the
limitations
this
one-size-fits-all
paradigm.
More
recently,
field
therapeutics
has
witnessed
shift
toward
other
modules,
including
cell
therapies,
high
molecular
weight
remedies,
personalized
medicines,
and
gene
therapies.
Such
advancements
in
therapeutic
modules
potential
to
revolutionize
healthcare
pave
way
medicines
are
more
efficient
with
minimal
side
effects.
Cell
gained
considerable
attention
regenerative
medicine.
Stem
cell-based
instance,
hold
promise
tissue
repair
regeneration,
ongoing
research
focusing
on
enhancing
their
efficacy
safety.
High
drugs
like
peptides
proteins
emerged
as
promising
because
specificity
diverse
biological
functions.
Engineered
developed
targeted
drug
delivery,
immunotherapy,
disease-modulation.
In
medicine,
tailored
treatments
individuals
based
specific
genetic
profiling,
lifestyle,
biomarkers,
disease
characteristics
all
implemented.
Clinicians
optimize
outcomes
minimize
adverse
effects,
using
mutations,
yielding
remarkable
results.
Gene
revolutionized
disorders
by
directly
targeting
underlying
abnormalities.
Innovative
techniques,
such
CRISPR-Cas9
allowed
precise
editing,
opening
up
possibilities
curing
previously
incurable
conditions.
conclusion,
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(3), P. 1088 - 1112
Published: Jan. 29, 2024
Cancer
immunotherapy,
aimed
at
reinvigorating
the
immune
system
to
induce
a
lasting
anticancer
response,
has
emerged
as
promising
approach
for
counteracting
evasive
tactics
of
cancer
cells.
This
study
delves
into
innovative
realm
stimuli-responsive
polymeric
nanomedicines
in
context
immunotherapy.
By
capitalizing
on
intricate
landscape
tumor
microenvironment
(TME),
which
orchestrates
suppression
and
progression,
offer
tailored
strategy
enhance
therapeutic
interventions.
The
aberrant
features
TME,
include
factors
such
low
pH,
inflammation,
oxidative
stress,
enzyme
overexpression,
serve
triggers
intelligent
delivery
systems
facilitated
by
functional
polymers.
dynamic
potential
overcome
challenges
faced
traditional
nanoparticle-based
immunotherapy
techniques,
presenting
platform
precisely
optimize
drug
within
locale.
As
synergistic
interaction
between
TME
unfolds,
novel
horizon
emerges
advance
efficacy
while
mitigating
its
associated
limitations.
Small,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Oct. 23, 2024
Abstract
Over
the
past
decade,
precision
medicine
has
garnered
increasing
attention,
making
significant
strides
in
discovering
new
therapeutic
drugs
and
mechanisms,
resulting
notable
achievements
symptom
alleviation,
pain
reduction,
extended
survival
rates.
However,
limited
target
specificity
of
primary
inter‐individual
differences
have
often
necessitated
high‐dosage
strategies,
leading
to
challenges
such
as
restricted
deep
tissue
penetration
rates
systemic
side
effects.
Material
science
advancements
present
a
promising
avenue
for
these
issues.
By
leveraging
distinct
internal
features
diseased
regions
application
specific
external
stimuli,
responsive
materials
can
be
tailored
achieve
targeted
delivery,
controllable
release,
biochemical
reactions.
This
review
aims
highlight
latest
stimuli‐responsive
their
potential
medicine.
Initially,
we
introduce
disease‐related
stimuli
capable
elucidating
reaction
principles
functional
groups.
Subsequently,
provide
detailed
analysis
representative
pre‐clinical
across
various
clinical
applications,
including
enhancements
treatment
cancers,
injury
diseases,
inflammatory
infection
high‐throughput
microfluidic
biosensors.
Finally,
discuss
some
challenges,
off‐target
effects,
long‐term
impacts
nano‐materials,
ethical
concerns,
offer
insights
into
future
perspectives
materials.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(42), P. 47420 - 47431
Published: Oct. 12, 2022
Biofilms
are
physical
barriers
composed
of
extracellular
polymeric
substances
(EPS)
that
enable
planktonic
bacteria
to
resist
host
responses
and
antibacterial
treatments,
complicating
efforts
clear
such
as
Pseudomonas
aeruginosa
(P.
aeruginosa)
thereby
contributing
persistently
chronic
infections.
As
such,
it
is
critical
develop
a
robust
antimicrobial
strategy
capable
effectively
eradicating
P.
biofilms
further
address
aggressive
clinical
infection.
In
this
study,
ultrasound-activatable
targeted
nanoparticles
were
designed
by
using
poly(lactic-co-glycolic
acid)
(PLGA)
encapsulate
phase-transformable
perfluoropentane
(PFP)
the
antibiotic
meropenem
via
double
emulsion
approach,
followed
conjugation
with
anti-P.
antibodies.
strategy,
ultrasound
exposure
can
trigger
PFP
produce
microbubbles,
inducing
ultrasonic
cavitation
effects
disrupt
EPS
components
allow
release
kill
directly
accelerate
associated
wound
healing.
These
eradicated
cleared
in
vitro
well
exhibited
potent
anti-infective
activity
vivo.
summary,
study
demonstrates
efficacy
sonobactericidal
means
reliably
eliminating
biofilms.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(8), P. 2113 - 2113
Published: Aug. 9, 2023
Drug-resistant
bacteria
and
infectious
diseases
associated
with
biofilms
pose
a
significant
global
health
threat.
The
integration
advancement
of
nanotechnology
in
antibacterial
research
offer
promising
avenue
to
combat
bacterial
resistance.
Nanomaterials
possess
numerous
advantages,
such
as
customizable
designs,
adjustable
shapes
sizes,
the
ability
synergistically
utilize
multiple
active
components,
allowing
for
precise
targeting
based
on
specific
microenvironmental
variations.
They
serve
alternative
antibiotics
diverse
medical
applications.
Here,
we
discuss
formation
resistance
strategies,
focuses
utilizing
distinctive
physicochemical
properties
nanomaterials
achieve
inherent
effects
by
investigating
mechanisms
Additionally,
advancements
developing
intelligent
nanoscale
agents
that
exhibit
responsiveness
both
endogenous
exogenous
responsive
stimuli.
These
hold
potential
enhanced
efficacy
stimuli
pH,
temperature,
light,
or
ultrasound.
Finally,
provide
comprehensive
outlook
existing
challenges
future
clinical
prospects,
offering
valuable
insights
development
safer
more
effective
nanomaterials.
