A robust microbiome signature for autism spectrum disorder across different studies using machine learning DOI Creative Commons
Lucía N. Peralta Marzal, David Rojas-Velázquez,

Douwe Rigters

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 8, 2024

Abstract Autism spectrum disorder (ASD) is a highly complex neurodevelopmental characterized by deficits in sociability and repetitive behaviour, however there great heterogeneity within other comorbidities that accompany ASD. Recently, gut microbiome has been pointed out as plausible contributing factor for ASD development individuals diagnosed with often suffer from intestinal problems show differentiated microbial composition. Nevertheless, studies rarely agree on the specific bacterial taxa involved this disorder. Regarding potential role of pathophysiology, our aim to investigate whether set relevant classification using sibling-controlled dataset. Additionally, we validate these results across two independent cohorts several confounding factors, such lifestyle, influence both studies. A machine learning approach, recursive ensemble feature selection (REFS), was applied 16S rRNA gene sequencing data 117 subjects (60 cases 57 siblings) identifying 26 discriminate controls. The average area under curve (AUC) bacteria dataset 81.6%. Moreover, selected tenfold cross-validation scheme (a total 223 samples—125 98 controls). We obtained AUCs 74.8% 74%, respectively. Analysis REFS identified can be used predict status children three distinct AUC over 80% best-performing classifiers. Our indicate strong association should not disregarded target therapeutic interventions. Furthermore, work contribute use proposed approach signatures datasets.

Language: Английский

A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression DOI Creative Commons
Sameer Jauhar, Danilo Arnone, David S. Baldwin

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(8), P. 3149 - 3152

Published: June 15, 2023

A recent "umbrella" review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating in pathophysiology of depression. We present reasons for why this conclusion is overstated, including methodological weaknesses process, selective reporting data, over-simplification, errors interpretation neuropsychopharmacological findings. use examples tryptophan depletion serotonergic molecular imaging, two research areas most relevant investigation serotonin, illustrate this.

Language: Английский

Citations

51
Meta-analytic prevalence of comorbid mental disorders in individuals at clinical high risk of psychosis: the case for transdiagnostic assessment DOI Creative Commons
Marco Solmi, Livia Soardo, Simi Kaur

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2291 - 2300

Published: June 1, 2023

Comorbid mental disorders in subjects at clinical high risk for psychosis (CHR-P) may impact preventive care. We conducted a PRISMA/MOOSE-compliant systematic meta-analysis, searching PubMed/PsycInfo up to June 21st, 2021 observational studies/randomized controlled trials reporting on comorbid DSM/ICD-mental CHR-P ( protocol ). The primary and secondary outcomes were baseline follow-up prevalence of disorders. also explored the association compared with versus psychotic/non-psychotic control groups, their functioning transition psychosis. random-effects meta-analyses, meta-regression, assessed heterogeneity/publication bias/quality (Newcastle Ottawa Scale, NOS). included 312 studies (largest meta-analyzed sample = 7834, any anxiety disorder, mean age 19.98 (3.40), females 43.88%, overall NOS > 6 77.6% studies). was 0.78 (95% CI 0.73-0.82, k 29) non-psychotic 0.60 0.36-0.84, 3) anxiety/mood disorders, 0.44 0.39-0.49, 48) mood 0.38 0.33-0.42, 50) depressive disorder/episode, 0.34 0.30-0.38, 69) 0.30 0.25-0.35, 35) major 0.29 CI, 0.08-0.51, trauma-related 0.23 0.17-0.28, 24) personality <0.23 other (I2 50% 71.01% estimates). disorder decreased over time (0.51, 95% 0.25-0.77 96 months), except substance use which increased (0.19, 0.00-0.39, 2, >96 months). Compared controls, status associated higher anxiety, schizotypal personality, panic, alcohol (OR from 2.90 1.54 without psychosis), 9.30 2.02) lower 0.41, psychosis). Higher disorder/schizotypal negatively (beta -0.40 -0.15), while dysthymic disorder/generalized 0.59 1.49). disorder/agoraphobia -2.39 -0.27) In conclusion, three-quarters have modulate functionig Transdiagnostic health assessment should be warranted CHR-P.

Language: Английский

Citations

49
Impact of air pollution and climate change on mental health outcomes: an umbrella review of global evidence DOI Open Access
Joaquim Raduà, Michele De Prisco, Vincenzo Oliva

et al.

World Psychiatry, Journal Year: 2024, Volume and Issue: 23(2), P. 244 - 256

Published: May 10, 2024

The impact of air pollution and climate change on mental health has recently raised strong concerns. However, a comprehensive overview analyzing the existing evidence while addressing relevant biases is lacking. This umbrella review systematically searched PubMed/Medline, Scopus PsycINFO databases (up to June 26, 2023) for any systematic with meta-analysis investigating association or outcomes. We used R metaumbrella package calculate stratify credibility according criteria (i.e., convincing, highly suggestive, weak) that address several biases, complemented by sensitivity analyses. included 32 reviews examined 284 individual studies 237 associations exposures hazards Most (n=195, 82.3%) involved pollution, rest (n=42, 17.7%) regarded (mostly focusing temperature: n=35, 14.8%). Mental outcomes in most (n=185, 78.1%) disorders, followed suicidal behavior (n=29, 12.4%), access care services (n=9, 3.7%), disorders-related symptomatology (n=8, 3.3%), multiple categories together (n=6, 2.5%). Twelve (5.0%) achieved convincing (class I) suggestive II) evidence. Regarding there was between long-term exposure solvents higher incidence dementia cognitive impairment (odds ratio, OR=1.139), some pollutants risk disorders (higher high vs. low levels carbon monoxide, CO: OR=1.587; vascular per 1 μg/m

Language: Английский

Citations

40
Mechanisms linking social media use to adolescent mental health vulnerability DOI Creative Commons
Amy Orben, Adrian Meier, Tim Dalgleish

et al.

Nature Reviews Psychology, Journal Year: 2024, Volume and Issue: 3(6), P. 407 - 423

Published: May 7, 2024

Language: Английский

Citations

36
Changes in Incident Schizophrenia Diagnoses Associated With Cannabis Use Disorder After Cannabis Legalization DOI Creative Commons
Daniel T. Myran, Michael Pugliese,

Lyndsay D. Harrison

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(2), P. e2457868 - e2457868

Published: Feb. 4, 2025

Importance Despite public health concerns that cannabis legalization may increase the number of cases schizophrenia caused by cannabis, there is limited evidence on this topic. Objective To examine changes in population-attributable risk fraction (PARF) for use disorder (CUD) associated with after liberalization medical and nonmedical Canada. Design, Setting, Participants This population-based cohort study was conducted Ontario, Canada, from January 1, 2006, to December 31, 2022, among 13 588 681 people aged 14 65 years without a history schizophrenia. Exposures Diagnosis CUD emergency department or hospital setting ( International Statistical Classification Diseases Related Health Problems, Tenth Revision, Canada [ ICD-10-CA ] codes F12x T40.7). Main Outcome Measures Changes PARF F20x F25x Diagnostic Manual Mental Disorders [Fourth Edition] DSM-IV code 295x) over 3 policy periods: prelegalization (January 2006 November 2015), (December 2015 September 2018), (October 2018 2022). A secondary outcome diagnosis psychosis not otherwise specified (NOS) F29x 298x). Segmented linear regression used 2018. Results The included individuals (mean [SD] age, 39.3 [16.1] years; 6 804 906 males [50.1%]), whom 118 650 (0.9%) had CUD. total 91 106 (0.7%) developed (80 523 470 031 [0.6%] general population vs 10 583 [8.9%] CUD). almost tripled 3.7% (95% CI, 2.7%-4.7%) during period 10.3% 8.9%-11.7%) period. postlegalization ranged 18.9% 16.8%-21.0%) 19 24 1.8% 1.1%-2.6%) females 45 years. annual incidence stable time, while NOS increased 30.0 55.1 per 100 000 (83.7%) relative steadily no accelerations changes, increases accelerated liberalization. Conclusions Relevance In proportion incident substantial policy. Ongoing research indicated understand long-term associations prevalence psychotic disorders.

Language: Английский

Citations

4
Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program DOI Creative Commons
Jean Addington,

Lu Liu,

Amy Braun

et al.

Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 3, 2025

Clinical ascertainment and clinical outcome are key features of any large multisite study. In the ProNET PRESCIENT research networks, Accelerating Medicines Partnership® Schizophrenia (AMP®SCZ) Ascertainment Outcome Measures Team aimed to establish a harmonized assessment protocol across these two networks define criteria primary secondary endpoints. addition developing protocol, goals this aspect AMP SCZ project were: (1) implement monitor training, participants, assessments; (2) provide expert input Psychosis Risk Evaluation, Data Integration Computational Technologies: Processing, Analysis, Coordination Center (PREDICT-DPACC) for data collection, quality control, preparation analysis measures; (3) ongoing support analysis, reporting data. This paper describes endpoints outcomes, rationale selection measures, extensive training staff, (4) measures study which includes several sites where English is not native language; (5) measure stability over time in observational comparing ratings at baseline 2-month follow up. Watch Dr. Jean Addington discuss her work article: https://vimeo.com/1040425281 .

Language: Английский

Citations

4
Exercise as a transdiagnostic intervention for improving mental health: an umbrella review DOI Creative Commons

Marco Solmi,

Ilaria Basadonne, Luca Bodini

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

2
Associations between mental and physical conditions in children and adolescents: An umbrella review DOI Creative Commons
Gonzalo Arrondo, Marco Solmi, Elena Dragioti

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 137, P. 104662 - 104662

Published: April 12, 2022

We mapped the evidence on type and strength of associations between a broad range mental physical conditions in children adolescents, by carrying out an umbrella review, i.e., quantitative synthesis previous systematic reviews meta-analyses. also assessed to which extent links vary across disorders or, contrast, are transdiagnostic. Based pre-established protocol, we retained 45 reviews/meta-analyses, encompassing around 12.5 million participants. In analyses limited most rigorous estimates, found for following associations: ADHD-asthma, ADHD-obesity, depression-asthma. A transdiagnostic association was confirmed asthma anxiety/ASD/depression/bipolar disorder, obesity ADHD/ASD/depression, dermatitis ASD/ADHD. conclude that allergic likely be associated with adolescents. Our results can help clinicians explore potential children/adolescent provide road map future studies aimed at shading light underlying factors.

Language: Английский

Citations

66
Ethical considerations for precision psychiatry: A roadmap for research and clinical practice DOI Creative Commons
Paolo Fusar‐Poli, Mirko Manchia, Nikolaos Koutsouleris

et al.

European Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 63, P. 17 - 34

Published: Aug. 27, 2022

Language: Английский

Citations

65
Thirty years of research on physical activity, mental health, and wellbeing: A scientometric analysis of hotspots and trends DOI Creative Commons
Michel Sabé, Chaomei Chen, Othman Sentissi

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Aug. 9, 2022

The sheer volume of research publications on physical activity, mental health, and wellbeing is overwhelming. aim this study was to perform a broad-ranging scientometric analysis evaluate key themes trends over the past decades, informing future lines research. We searched Web Science Core Collection from inception until December 7, 2021, using appropriate search terms such as “physical activity” or “mental health,” with no limitation language time. Eligible studies were articles, reviews, editorial material, proceeding papers. retrieved 55,353 documents published between 1905 2021. annual scientific production exponential mean growth rate 6.8% since 1989. 1988–2021 co-cited reference network identified 50 distinct clusters that presented significant modularity silhouette scores indicating highly credible ( Q = 0.848, S 0.939). This 6 major namely cardiovascular diseases, somatic disorders, cognitive decline/dementia, illness, athletes' performance, related health issues, eating COVID-19 pandemic. A focus latest found greenness/urbanicity (2014), concussion/chronic traumatic encephalopathy (2015), (2019) most active USA central, Chinese network, although important in size, relatively isolated. Our results strengthen expand central role activity public calling for systematic involvement professionals stakeholders decision-making process.

Language: Английский

Citations

39