Cell Membrane Biomimetic Nanoparticles with Potential in Treatment of Alzheimer’s Disease

Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2336 - 2336

Published: March 3, 2023

Alzheimer's disease (AD) is to blame for about 60% of dementia cases worldwide. The blood-brain barrier (BBB) prevents many medications AD from having clinical therapeutic effects that can be used treat the affected area. Many researchers have turned their attention cell membrane biomimetic nanoparticles (NPs) solve this situation. Among them, NPs extend half-life drugs in body as "core" wrapped drug, and acts "shell" functionalize NPs, which further improve delivery efficiency nano-drug systems. Researchers are learning circumvent BBB's restriction, prevent harm body's immune system, period spend circulation, good biocompatibility cytotoxicity, increases efficacy drug release. This review summarized detailed production process features core introduced extraction methods fusion NPs. In addition, targeting peptides modifying target BBB demonstrate broad prospects systems were summarized.

Language: Английский

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Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6147 - 6147

Published: March 24, 2023

Accumulating evidence indicates that chronic exposure to a low level of pesticides found in diet affects the human gut-microbiota-blood-brain barrier (BBB) axis. This axis describes physiological and bidirectional connection between microbiota, intestinal (IB), BBB. Preclinical observations reported gut microbial alteration induced by pesticides, also known as dysbiosis, condition associated not only with gastrointestinal disorders but diseases affecting other distal organs, such However, interplay IB, BBB is still fully explored. In this review, we first consider similarities/differences these two barriers different pathways link microbiota better understand dialogue bacteria brain. We then discuss effects oral pesticide on gut-microbiota-BBB raise awareness danger exposure, especially during perinatal period (pregnant women offspring).

Language: Английский

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Advances of 3D Cell Co-Culture Technology Based on Microfluidic Chips

Biosensors, Journal Year: 2024, Volume and Issue: 14(7), P. 336 - 336

Published: July 10, 2024

Cell co-culture technology aims to study the communication mechanism between cells and better reveal interactions regulatory mechanisms involved in processes such as cell growth, differentiation, apoptosis, other cellular activities. This is achieved by simulating complex organismic environment. Such studies are of great significance for understanding physiological pathological multicellular organisms. As an emerging cultivation technology, 3D based on microfluidic chips, can efficiently, rapidly, accurately achieve co-culture. accomplished leveraging unique microchannel structures flow characteristics chips. The simulate native microenvironment providing a new technical platform studying intercellular communication. It has been widely used research oncology, immunology, neuroscience, fields. In this review, we summarize provide insights into design systems detection methods employed systems, applications these models.

Language: Английский

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Biomimetic Dual-Target Theranostic Nanovaccine Enables Magnetic Resonance Imaging and Chemo/Chemodynamic/Immune Therapy of Glioma

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(21), P. 27187 - 27201

Published: May 15, 2024

Development of theranostic nanomedicines to tackle glioma remains be challenging. Here, we present an advanced blood–brain barrier (BBB)-crossing nanovaccine based on cancer cell membrane-camouflaged poly(N-vinylcaprolactam) (PVCL) nanogels (NGs) incorporated with MnO2 and doxorubicin (DOX). We show that the disulfide bond-cross-linked redox-responsive PVCL NGs can functionalized dermorphin imiquimod R837 through membrane functionalization. The formed having a size 220 nm are stable, deplete glutathione, responsively release both Mn2+ DOX under simulated tumor microenvironment exert chemo/chemodynamic therapy mediated by Mn2+, respectively. combined induces immunogenic death maturate dendritic cells (DCs) activate tumor-killing T cells. Further, composed membranes as antigens, adjuvant abilities DC maturation macrophages M1 repolarization, Mn2+-mediated stimulator interferon gene activation effectively act targets immune With dermorphin-mediated BBB crossing, membrane-mediated homologous targeting, Mn2+-facilitated magnetic resonance (MR) imaging property, designed NG-based enables MR combination chemo-, chemodynamic-, imnune orthotopic significantly decreased recurrence rate.

Language: Английский

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CRISPR-Cas9-Mediated Gene Therapy in Neurological Disorders

Molecular Neurobiology, Journal Year: 2021, Volume and Issue: 59(2), P. 968 - 982

Published: Nov. 23, 2021

Language: Английский

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Roles of Long Non-coding RNAs in the Development of Aging-Related Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 15

Published: March 14, 2022

Aging-related neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), and amyotrophic lateral sclerosis (ALS), are gradually becoming the primary burden of society cause significant health-care concerns. Aging is a critical independent risk factor for diseases. The pathological alterations diseases tightly associated with mitochondrial dysfunction, inflammation, oxidative stress, which in turn stimulates further progression Given potential research value, lncRNAs have attracted considerable attention. LncRNAs play complex dynamic roles multiple signal transduction axis neurodegeneration. Emerging evidence indicates that exert crucial regulatory effects initiation development aging-related This review compiles underlying mechanisms aging related Besides, we discuss aging. In addition, crosstalk network also explored.

Language: Английский

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Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 949, P. 175717 - 175717

Published: April 11, 2023

Language: Английский

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Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: May 13, 2024

Abstract Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), and traumatic brain injury (TBI) exemplify complexities diversities complicate their early detection development effective treatments. Amid these challenges, emergence nanotechnology extracellular vesicles (EVs) signals new dawn for treating diagnosing CNS ailments. EVs are cellularly derived lipid bilayer nanosized particles pivotal in intercellular communication within have potential to revolutionize targeted therapeutic delivery identification novel biomarkers. Integrating with amplifies diagnostic capabilities, opening avenues managing diseases. This review focuses on examining fascinating interplay between theranostics. Through highlighting remarkable advancements unique methodologies, we aim offer valuable perspectives how approaches can bring about revolutionary change management. The objective is harness distinctive attributes forge personalized, efficient interventions disorders, thereby providing beacon hope affected individuals. In short, confluence heralds promising frontier impactful treatments against diseases, which continue pose significant challenges. By focusing personalized powerful methods, might improve quality patients.

Language: Английский

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The Japanese Encephalitis Antigenic Complex Viruses: From Structure to Immunity

Viruses, Journal Year: 2022, Volume and Issue: 14(10), P. 2213 - 2213

Published: Oct. 8, 2022

In the last three decades, several flaviviruses of concern that belong to different antigenic groups have expanded geographically. This has resulted in presence often more than one virus from a single group some areas, while Europe, Africa and Australia, additionally, multiple viruses belonging Japanese encephalitis (JE) serogroup co-circulate. Morphological heterogeneity dictates antibody recognition affects neutralization, which influences infection control. The latter is further impacted by sequential infections involving diverse co-circulating within region their cross-reactivity. ensuing complex molecular virus-host interplay leads either cross-protection or disease enhancement; however, determinants mechanisms driving these outcomes are unclear. this review, we provide an overview epidemiology four JE serocomplex viruses, parameters affecting flaviviral recognition, host immune responses current knowledge cross-reactivity differential clinical outcomes, may inform future preventative therapeutic interventions.

Language: Английский

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Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Oct. 4, 2023

Brain activity governing cognition and behaviour depends on the fine-tuned microenvironment provided by a tightly controlled blood-brain barrier (BBB). endothelium dysfunction is hallmark of BBB breakdown in most neurodegenerative/neuroinflammatory disorders. Therefore, identification new endogenous molecules involved endothelial cell disruption essential to better understand dynamics. Cortistatin neuroimmune mediator with anti-inflammatory neuroprotective properties that exerts beneficial effects peripheral endothelium. However, its role healthy injured brain remains be evaluated. Herein, this study aimed investigate potential function therapeutic cortistatin regulating neuroinflammatory/neurodegenerative environment.Wild-type cortistatin-deficient murine human cells were used for an vitro model, where simulated ischemia-like environment was mimicked. Endothelial permeability, junction integrity, immune response presence absence evaluated using different size tracers, immunofluorescence labelling, qPCR, ELISA. molecular mechanisms underlying dynamics assessed RNA-sequencing analysis. leakage adult mice injected LPS.The lack predisposes weakening increased tight-junctions breakdown, dysregulated activity. We demonstrated both damaged uninjured isolated from mice, present and/or deactivated genetic programming. These pathways, related basic physiology but also crucial repair after damage (e.g., extracellular matrix remodelling, angiogenesis, oxygen, signalling, metabolites transport), are dysfunctional make lacking non-responsive any further injury. Treatment reversed hyperpermeability, disruption, inflammatory response, reduced vivo leakage.The neuropeptide has key cerebral microvasculature develop canonical balanced damage. The reparative accompanied modulation rescue integrity. Cortistatin-based therapies could emerge as novel pleiotropic strategy ameliorate disorders disrupted BBB.

Language: Английский

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