Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 163 - 205

Published: April 18, 2024

Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)

Language: Английский

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Novel therapeutic regimens against Helicobacter pylori: an updated systematic review

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: June 7, 2024

Helicobacter pylori ( H. ) is a strict microaerophilic bacterial species that exists in the stomach, and infection one of most common chronic infections affecting humans. Eradicating preferred method for long-term prevention complications such as gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue lymphoma, cancer. However, first-line treatment with triple therapy quadruple has been unable to cope increasing antibacterial resistance. To provide an updated review resistance, well related options, we searched PubMed articles published until March 2024. The key search terms were “ ”, infection”, diseases”, eradication”, resistance.” Despite use antimicrobial agents, annual decline eradication rate continues. Emerging therapies, development new strong acid blocker vonoprazan, probiotic adjuvant therapy, vaccine are exciting. effectiveness these treatments needs be further evaluated. It worth mentioning idea altering oxygen environment juice not able survive hot topic should considered plans. Various strategies eradicating , including antibacterials, vaccines, probiotics, biomaterials, continuously evolving. A novel approach involving alteration concentration within growth emerged promising strategy.

Language: Английский

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The interplay of gut microbiota, obesity, and depression: insights and interventions

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Oct. 30, 2024

Language: Английский

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Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: June 3, 2024

This mini-review explores the role of short-chain fatty acids (SCFAs) in posttraumatic stress disorder (PTSD). Highlighting microbiota-gut-brain axis, this study investigated bidirectional communication between gut microbiome and mental health. SCFAs, byproducts microbial fermentation, have been examined for their potential impact on PTSD, with a focus molecular mechanisms therapeutic interventions. review discusses changes SCFA levels bacterial profiles individuals emphasizing need further research. Promising outcomes from clinical trials using probiotics fermented formulations suggest avenues PTSD management. Future directions involve establishing comprehensive human cohorts, integrating multiomics data, employing advanced computational methods, goal deepening our understanding SCFAs exploring microbiota-targeted

Language: Английский

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Mitochondria-based holistic 3PM approach as the ‘game-changer’ for individualised rehabilitation—the proof-of-principle model by treated breast cancer survivors

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(4), P. 559 - 571

Published: Nov. 20, 2024

Breast cancer belongs to the most commonly diagnosed malignancies worldwide, with its increasing incidence paralleled by advances in early diagnostics and effective treatments resulting significantly improved survival rates. However, breast survivors often experience reduced quality of life linked long-term health burden as a consequence aggressive oncological applied. Their frequently recorded complains include chronic fatigue, physical activity, disordered sleep, chronification pain, severe mental impairments-all per evidence are associated compromised mitochondrial impaired homeostasis. Self-report survivor is included this article illustrate currently uncovered patient needs. This highlights mechanisms behind suboptimal damage, introduces novel, mitochondria-based holistic approach addressing rehabilitation concepts for following advanced principles predictive, preventive personalised medicine (3PM). By operating via function, proposed triggers systemic effects at molecular, sub/cellular organismal levels positively affecting energy metabolism, repair well creating, therefore, highly algorithms tailored an individualised profile. The methodology integrates assessments utilising homeostasis biomarkers tear fluid non-invasive diagnostic tool, nutraceuticals lifestyle adjustments. introduced aligns 3PM, offering proactive framework managing persistent post-treatment symptoms cohort survivors. Furthermore, presented also applicable pre-habilitation programmes considering needs other cohorts affected diseases such CVD orthopaedic disorders planned major surgical incisions, who require individually adapted pre- programmes. Implementing innovative strategies may lead full recovery, sustainable conditions and, facilitating patients' comeback normal daily activities, family professional life. Contextually, considered 'proof-of-principle' model 3PM-related paradigm shift from reactive cost-effective management both primary secondary care benefiting large spectrum cohorts, individuals society large.

Language: Английский

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The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 12

Published: Feb. 28, 2025

Interactions in the gut-brain crosstalk have led to development of an entirely new concept: "microbiota-gut-brain axis". Microbiota has gained considerable attention relation disorders a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, mood disorders. This review aims summarize recent trends insights into role consequences gut microbiota brain health pediatric Dysbiosis may be associated with increased risk diseases that lead different disruptions conditions, including mental issues. During dysbiosis, neuropsychological stress hormones usually affect oxytocin GABA neurons are significantly reduced. Current studies report major depression, cognitive dysfunction closely dysbiosis. In last few years, handful clinical emerged, illustrating potential for bidirectional relationship interactions humans. Perhaps some most crucial investigations demonstrating overlapping relationships human axis come from trials focusing on modulating noting significant correlates. A field is emerging gene-editing technology could represent tool improve microbial characteristics. approach particularly relevant neurodegenerative brain-gut linked loss species and/or high pathobiont load.

Language: Английский

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Carbapenem-Resistant Pseudomonas aeruginosa’s Resistome: Pan-Genomic Plasticity, the Impact of Transposable Elements and Jumping Genes

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 353 - 353

Published: March 31, 2025

Pseudomonas aeruginosa, a Gram-negative, motile bacterium, may cause significant infections in both community and hospital settings, leading to substantial morbidity mortality. This opportunistic pathogen can thrive various environments, making it public health concern worldwide. P. aeruginosa’s genomic pool is highly dynamic diverse, with pan-genome size ranging from 5.5 7.76 Mbp. versatility arises its ability acquire genes through horizontal gene transfer (HGT) via different genetic elements (GEs), such as mobile (MGEs). These MGEs, collectively known the mobilome, facilitate spread of encoding resistance antimicrobials (ARGs), heavy metals (HMRGs), virulence (VGs), metabolic functions (MGs). Of particular are acquired carbapenemase (ACGs) other β-lactamase genes, classes A, B [metallo-β-lactamases (MBLs)], D carbapenemases, which lead increased antimicrobial resistance. review emphasizes importance mobilome understanding aeruginosa.

Language: Английский

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Beyond hormones: 3PM approach to vaginal microbiota dynamics in postmenopausal women

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

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Causal association of juvenile idiopathic arthritis or JIA-associated uveitis and gut microbiota: a bidirectional two-sample Mendelian randomisation study

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 24, 2024

Background The gut microbiota significantly influences the onset and progression of juvenile idiopathic arthritis (JIA) associated uveitis (JIAU); however, causality remains unclear. This study aims to establish a causal link between JIA or JIAU. Methods Using publicly available genome-wide association studies (GAWS) summary data, we conducted two-sample Mendelian randomisation (MR) analysis employing various methods, namely inverse variance weighted (IVW), simple mode, median MR-Egger regression assess JIAU microbiota. Sensitivity analyses, including Cochrane’s Q test, intercept leave-one-out MR-PRESSO, were performed evaluate robustness MR results. Subsequently, reverse was determine gene-predicted abundance Results revealed variations risk. Specifically, increased genus Ruminococcaceae UCG013 (OR: 0.055, 95%CI: 0.006–0.103, p = 0.026) UCG00 3 ( β : 0.06, 0.003–0.117, 0.041) correlated with an risk JIA, while Lachnospiraceae UCG001 0.833, 0.699~0.993, 0.042) reduced among others. confirmed robustness. Conclusions provides substantial evidence supporting genetically predicted It highlights significant role intestinal flora in development, suggesting their potential as novel biomarkers for diagnosis prevention. These findings offer valuable insights mitigate impact

Language: Английский

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Distribution of chaperone-usher fimbriae and curli fimbriae among uropathogenic Escherichia coli

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 14, 2024

Language: Английский

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