Matrix Biology, Journal Year: 2016, Volume and Issue: 52-54, P. 363 - 383
Published: Jan. 23, 2016
Language: Английский
The Lancet, Journal Year: 2015, Volume and Issue: 386(9991), P. 376 - 387
Published: March 4, 2015
Language: Английский
Citations
2529
Cold Spring Harbor Perspectives in Biology, Journal Year: 2011, Volume and Issue: 3(12), P. a005058 - a005058
Published: Sept. 14, 2011
Pengfei Lu1,2, Ken Takai2, Valerie M. Weaver3 and Zena Werb2 Breakthrough Breast Cancer Research Unit, Paterson Institute for Wellcome Trust Centre Cell Matrix Research, Faculty of Life Sciences, University Manchester, Manchester M20 4BX, United Kingdom Department Anatomy Program in Developmental Biology, California, San Francisco, California 94143-0452 Surgery Center Bioengineering Tissue Regeneration, 94143 Correspondence: zena.werb{at}ucsf.edu
Language: Английский
Citations
2009
Frontiers in Immunology, Journal Year: 2015, Volume and Issue: 6
Published: May 6, 2015
The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and cell surface receptors HA have been proposed to pivotal roles in proliferation, migration, invasion, which are necessary for inflammation cancer progression. CD44 receptor HA-mediated motility (RHAMM) the two main HA-receptors whose biological functions human murine inflammations tumor cells investigated comprehensively. was initially considered be only an inert connective tissues, but is now known as "dynamic" molecule with constant turnover many tissues through rapid metabolism that involves molecules various sizes: high molecular weight (HMW HA), low HA, oligosaccharides. intracellular signaling pathways initiated by interactions RHAMM lead inflammatory tumorigenic responses complex. Interestingly, these dual tumorigenesis. For example, presence involved initiation arthritis, while absence genetic deletion arthritis mouse model increases rather than decreases disease severity. Similar exist progression cancer. overexpression most commonly linked progression, whereas loss associated malignant peripheral nerve sheath growth. may similarly perform functions. An abundance HMW can promote proliferation development cancer, antagonists HA-CD44 inhibit growth vitro vivo interfering interaction. This review describes development/progression, how therapeutic strategies block key inflammatory/tumorigenic processes developed rodent diseases.
Language: Английский
Citations
719
Bioactive Materials, Journal Year: 2017, Volume and Issue: 3(1), P. 129 - 138
Published: Sept. 19, 2017
Bone is consisted of bone matrix, cells and bioactive factors, matrix the combination inorganic minerals organic polymers. Type I collagen fibril made five triple-helical chains main polymer in matrix. It plays an important role formation remodeling process. Moreover, one most commonly used scaffold materials for tissue engineering due to its excellent biocompatibility biodegradability. However, low mechanical strength osteoinductivity limit wider applications regeneration field. By incorporating different biomaterials, properties such as porosity, structural stability, osteoinductivity, osteogenicity matrixes can be largely improved. This review summarizes categorizes kinds biomaterials including bioceramic, carbon components fabricate based composite scaffolds regeneration. possible directions future research development this field are also proposed.
Language: Английский
Citations
390
Macromolecular Bioscience, Journal Year: 2013, Volume and Issue: 13(4), P. 395 - 421
Published: March 19, 2013
Abstract Research and development in the design, synthesis, modification, evaluation, characterization of polysaccharide‐based bioactive polymeric materials for guiding promoting new tissue in‐growth is reviewed. Emphasis given this interdisciplinary field engineering (TE) with particular reference to bone, cartilage, skin TE. Current strategies scaffold‐guided TE approaches using polymers natural origin their composites are elaborated. Innovative modification techniques creating functional advanced applications presented. Challenges possible solutions technological innovation factor molecules incorporation surface functionalization improving fabrication biomaterials scaffolds cost‐effective also magnified image
Language: Английский
Citations
256
Biomolecules, Journal Year: 2021, Volume and Issue: 11(10), P. 1518 - 1518
Published: Oct. 15, 2021
Hyaluronic acid (HA) is a natural polymer, produced endogenously by the human body, which has unique physicochemical and biological properties, exhibiting desirable biocompatibility biodegradability. Therefore, it been widely studied for possible applications in area of inflammatory diseases. Although exogenous HA described as unable to restore or replace properties activities endogenous HA, can still provide satisfactory pain relief. This review aims discuss advances that have achieved treatment diseases using hyaluronic key ingredient, essentially focusing on studies carried out between years 2017 2021.
Language: Английский
Citations
249
Materials Science and Engineering R Reports, Journal Year: 2021, Volume and Issue: 146, P. 100641 - 100641
Published: July 30, 2021
Language: Английский
Citations
188
Healthcare, Journal Year: 2024, Volume and Issue: 12(16), P. 1648 - 1648
Published: Aug. 19, 2024
Osteoarthritis (OA) is one of the most common causes disability around globe, especially in aging populations. The main symptoms OA are pain and loss motion function affected joint. Hyaline cartilage has limited ability for regeneration due to its avascularity, lack nerve endings, very slow metabolism. Total joint replacement (TJR) date been used as treatment end-stage disease. Various joint-sparing alternatives, including conservative surgical treatment, have proposed literature; however, no fully successful restoring hyaline cartilage. mechanical frictional properties paramount importance terms resistance continuous loading. numerous changes macro- microstructure cartilage, affecting properties. Increased friction reduced load-bearing capability accelerate further degradation tissue by exerting increased loads on healthy surrounding tissues. Cartilage repair techniques aim restore reduce Numerous studies investigated biological aspects progression techniques. However, vital must be addressed too. This review, therefore, addresses articular during OA, it summarizes outcomes
Language: Английский
Citations
63
Future Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 10(1)
Published: April 24, 2024
Abstract Background Hyaluronic acid (HA) has a broad range of cosmetic and therapeutic applications due to its unique physicochemical properties involvement in various essential biological processes, including cell signaling, wound reparation, tissue regeneration. Main body In this review, we provide comprehensive overview HA, history, properties, roles, molecular biology, biochemistry (including occurrence, biosynthesis, degradation), as well chemical modifications conventional emerging production methods. We also examine HA's medical, pharmaceutical, derivatives arthrology, ophthalmology, healing, odontology, oncology, drug delivery, 3D bioprinting, cosmetology. Finally, discuss the potential role HA preventing Covid-19. Conclusion acid, naturally found substance, shown immense clinic. Thus, it is imperative highlight diverse fields impacting lives patients healthy individuals.
Language: Английский
Citations
23
Journal of Molecular Medicine, Journal Year: 2011, Volume and Issue: 90(6), P. 625 - 635
Published: Dec. 20, 2011
Language: Английский
Citations
186