Nature Reviews Urology, Journal Year: 2023, Volume and Issue: 21(2), P. 102 - 124
Published: Oct. 12, 2023
Language: Английский
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 5, 2025
Oxidative stress plays a pivotal role in male infertility by impairing sperm function through various molecular mechanisms. This review explores the impact of excessive reactive oxygen species (ROS) on spermatozoa, particularly focusing lipid peroxidation, DNA fragmentation, and protein oxidation. Lipid peroxidation damages membranes, reducing fluidity motility. ROS-induced fragmentation compromises genetic integrity, potentially leading to adverse offspring outcomes. Protein oxidation alters key structural proteins, motility ability fertilize an egg. The primary sources oxidative include leukocyte activity, mitochondrial dysfunction, environmental factors such as smoking pollution. Despite presence natural antioxidant defenses, spermatozoa are vulnerable due limited repair highlights importance early intervention therapies lifestyle changes mitigate detrimental effects fertility. Further research is essential enhance therapeutic approaches improve reproductive
Language: Английский
Citations
4
Reproductive Toxicology, Journal Year: 2025, Volume and Issue: 132, P. 108832 - 108832
Published: Jan. 6, 2025
Language: Английский
Citations
2
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
Oxidative stress (OS) is established as a key factor in the etiology of both male and female infertility, arising from an imbalance between reactive oxygen species (ROS) production endogenous antioxidant (AOX) defenses. In men, OS adversely affects sperm function by inducing DNA damage, reducing motility, significantly impairing vitality through plasma membrane peroxidation loss integrity, ultimately compromising overall quality. women, implicated various reproductive disorders, including polycystic ovary syndrome, endometriosis, premature ovarian failure, leading to diminished oocyte quality, disrupted folliculogenesis, poorer outcomes. Antioxidant therapy represents promising intervention mitigate harmful effects ROS on health additions its easy accessibility, safety, low cost. Despite several findings suggesting improvements fertility potential with AOX therapy, data remains inconclusive regarding optimal dosage combination, duration treatment, specific patient populations most likely benefit. this review, we discuss role AOXs management infertile couples, focusing their biological mechanisms, adverse effects, therapeutic efficacy, clinical applications improving outcomes natural conception medically assisted reproduction. Additionally, highlight current practice patterns recommendations for supplementation during course infertility treatment. Further, provide overview limitations research topic insights future studies establish standardized regimens assess long-term impact such live birth rates miscarriage rates.
Language: Английский
Citations
2
Andrologia, Journal Year: 2020, Volume and Issue: 53(1)
Published: April 9, 2020
Reactive oxygen species (ROS) are free radicals derived from during normal cellular metabolism. ROS play a crucial role in the physiological processes and signalling pathways associated with male fertility. At concentrations, act as molecular mediators of signal transduction involved regulation hypothalamic–pituitary–gonadal axis, spermatogenesis steroidogenesis. They also trigger morphological changes required for sperm maturation, such DNA compaction flagellar modification. Furthermore, modulate attainment fertilising ability capacitation, hyperactivation, acrosome reaction sperm–oocyte fusion. Conversely, oxidative stress prevails when concentration overwhelms body's antioxidant defence. Various endogenous exogenous factors enhance synthesis resulting disruption structural functional integrity spermatozoa through induction apoptotic pathway oxidation molecules, lipids, proteins DNA. Therefore, maintenance balanced redox state is critical reproductive functions. This article discusses dual reproduction, highlighting well their pathological implications on
Language: Английский
Citations
120
Antioxidants, Journal Year: 2021, Volume and Issue: 10(1), P. 97 - 97
Published: Jan. 12, 2021
One important reason for male infertility is oxidative stress and its destructive effects on sperm structures functions. The particular composition of the membrane, rich in polyunsaturated fatty acids, easy access DNA to damage due cell specific cytologic metabolic features (no cytoplasm left cells unable mount responses) make it type metazoans most susceptible damage. In particular, spermatozoa genome an issue a cause infertility, usually associated with single- or double-strand paternal breaks. Various methods detecting fragmentation have become diagnostic tools prognosis such assays are available research laboratories andrology clinics. However, date, there not clear consensus community as their respective prognostic value. Nevertheless, understand that go well beyond alone. Oxidation bases, particularly guanine adenosine residues, sensitive residues alteration, starting point but also danger integrity embryo genetic material independently fragmentation. Due lack repair system and, if egg correct oxidized risk de novo mutation transmission exists. These will be carried every future individual progeny. Thus, addition affecting viability pregnancy itself, oxidation bases could development conditions young adults. Despite these issues, base has attracted much interest among clinicians simple, reliable, rapid consensual assessing this genome. technical another explaining why measurement included fertility likely strong evidence role outcome. It is, however, becoming assessment improve efficiency assisted reproductive technologies provide information embryonic developmental failures pathologies encountered offspring. objective work review relevant been out field epigenetic consequences.
Language: Английский
Citations
73
Free Radical Biology and Medicine, Journal Year: 2021, Volume and Issue: 164, P. 410 - 416
Published: Jan. 19, 2021
Language: Английский
Citations
69
Antioxidants, Journal Year: 2021, Volume and Issue: 10(7), P. 1096 - 1096
Published: July 8, 2021
Cooled preservation of semen is usually associated with artificial insemination and genetic improvement programs in livestock species. Several studies have reported an increase reactive oxidative species a decrease antioxidant substances sperm quality parameters during long-term storage at refrigerated temperatures. The supplementation antioxidants extenders before refrigeration could reduce this detrimental effect. Various been tested, both enzymatic, such as superoxide dismutase catalase, non-enzymatic, reduced glutathione, vitamins E C melatonin. However, the problem stress has not fully resolved. effects for semen-cooled reviewed depth. Therefore, objective present study was to review efficiency extender cooled
Language: Английский
Citations
61
Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13
Published: April 28, 2022
Infection and inflammation are relevant entities of male reproductive disorders that can lead to sub-/infertility. Associated damage the testis affected men in rodent models include leukocytic infiltration, edema formation, fibrosis, germ cell loss reduced androgen levels. Negative effects on spermatogenesis thought be elicited by oxidative stress sustained mostly increased levels ROS pro-inflammatory cytokines. Under normal conditions these cytokines have physiological functions. However, as seen infection, but also obesity cancer harmful for cells impair steroidogenesis. As a summary, there is mounting evidence activation inflammatory pathways rather common feature various forms testicular extends beyond established infectious/inflammatory cues. This mini review will focus mechanisms how dysbalance local factors contributes disturbances
Language: Английский
Citations
61
Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 193 - 193
Published: Jan. 19, 2022
Micro- and nanoplastics (MPs/NPs) are among the most widely distributed pollutants in environment. It has been suggested that exposure to MPs/NPs can trigger toxicity pathways which inflammation oxidative stress (OS) play a pivotal role. Once absorbed, may act locally or access bloodstream and, following translocation process, reach several organs tissues, including gonads. Notably, bioaccumulate human murine placenta, opening new scenarios for toxicological evaluations. We review recent studies on effects of reproductive health aquatic terrestrial organisms both sexes, focusing role OS antioxidant defence system failure as main underlying mechanisms. Alterations gametogenesis, embryonic offspring development, survival have shown often related broken redox balance. All these detrimental inversely particle size, whereas they closely linked shape, plastic polymer type, superficial functionalization, concentration, time exposure. To date, provide insights into impacts, but no conclusions be drawn reproduction toxicity. The implication few substances reveals their potential mitigating MP-induced toxic effects.
Language: Английский
Citations
56
Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13
Published: March 23, 2022
According to the official statistics of World Health Organization, at least 48 million couples and 186 people suffer from infertility. Varicocele has been recognized as leading cause male infertility can affect spermatogenesis testicular epididymal disorders through multiple diverse pathophysiological processes. Reactive oxygen species (ROS) produced by oxidative stress have reconciled an important pathogenic factor throughout course varicocele. Testis respond heat stress, hypoxia, inflammation cost producing excessive ROS. High levels ROS lead not only lipid peroxidation or DNA damage, but also inactivating enzymes proteins in spermatogenesis. This review studies its role pathophysiology molecular biology varicocele context a decline fertility.
Language: Английский
Citations
49