Role of Achyranthes aspera in neurodegenerative diseases: current evidence and future directions DOI Creative Commons
Huaiqing Luo,

S.H.Y. Wei,

Shujun Fu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Neurodegenerative diseases are caused by the progressive degeneration of neurons and/or their myelin sheaths, ultimately leading to cognitive and motor dysfunction. Due complex pathogenesis limited efficacy therapeutic drugs, these have attracted significant attention. Achyranthes aspera, belongs family Amaranthaceae, has been extensively used in traditional folk medicines for treatment various ailments. Modern research revealed that aspera possesses pharmacological effects, including cardiocerebrovascular protection, immune regulation, antioxidation, anti-aging. Furthermore, neuroprotective effects confirmed numerous scientific studies. This review focuses on primary mechanisms prevention neurodegenerative diseases, as well potential application prospects. aims provide insights into clinical applications directions diseases.

Language: Английский

Acute nitrite exposure-induced oxidative damage, endoplasmic reticulum stress, autophagy and apoptosis caused gill tissue damage of grass carp (Ctenopharyngodon idella): Relieved by dietary protein DOI Creative Commons
Hongju Liu,

Min Dong,

Wei‐Dan Jiang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 243, P. 113994 - 113994

Published: Aug. 19, 2022

Nitrite poses a serious threat to intensive aquaculture. Protein, as major nutrient in animals, is vital for protecting animal tissues from damage. In this study, we investigated the protective effect of dietary protein on gill tissue structure and underlying mechanisms sub-adult grass carp (Ctenopharyngodon idella) exposed nitrite stress. Six iso-energetic semi-purified diets containing different levels (16-31 %) were formulated, fed fish 60 d. The then solution 4 Histopathological observation determination related indices (serum glucose, serum cortisol, nitric oxide, peroxynitrite, reactive oxygen species, malondialdehyde, carbonyl) showed that 22-25 % significantly alleviated nitrite-induced stress response, damage oxidative Further research found suitable suppressed endoplasmic reticulum (ERS) 78 kDa glucose-regulated (GRP78) signaling pathway which possibly activated autophagy apoptosis. Interestingly, discovered proper reduced autophagy, probably through unc-51-like kinase 1 (Ulk1), BCL-2-interacting myosin-like coiled-coil (Beclin1), autophagy-related gene 5 (Atg5), Atg12, microtubule-associated protein1 light chain 3 (LC3), BCL-2 interacting (BNIP3) receptor P62 (p62). We also an appropriate inhibited apoptosis via mitochondrial death pathways. summary, our findings are first demonstrate can play role against injury.

Language: Английский

Citations

27
Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation DOI Open Access
Kouji Fukuyama, Eishi Motomura, Motohiro Okada

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2070 - 2070

Published: Jan. 20, 2023

Although a number of mood-stabilising atypical antipsychotics and antidepressants modulate serotonin type 7 receptor (5-HT7), the detailed contributions 5-HT7 function to clinical efficacy pathophysiology have not been fully understood. The antipsychotic agent, lurasidone, partial agonist reuptake inhibitor, vortioxetine, exhibit higher binding affinity than other conventional antidepressants. To date, initially expected rapid onset antidepressant effects-in comparison with or antipsychotics-due inhibition has observed lurasidone vortioxetine; however, several studies suggest that likely contributes quality life patients schizophrenia mood disorders via improvement cognition. Furthermore, recent preclinical reported might mitigate antipsychotic-induced weight gain metabolic complication by blocking monoamine receptors. Further for development modulation against neurodevelopmental neurodegenerative diseases ongoing. various findings from indicate possibility modifications can provide two independent strategies. first is ameliorates dysfunction inter-neuronal transmission in mature networks. activation improve due microstructure abnormality neurotransmission network-which could be unaffected therapeutic agents-via modulating intracellular signalling during stage loss neural networks aging. This review attempts describe current novel applications based on findings.

Language: Английский

Citations

15
Arsenic induced autophagy-dependent apoptosis in hippocampal neurons via AMPK/mTOR signaling pathway DOI
Yao Chen, Xudan Liu, Qianhui Zhang

et al.

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 179, P. 113954 - 113954

Published: July 20, 2023

Language: Английский

Citations

15
Mechanisms of intermittent theta-burst stimulation attenuating nerve injury after ischemic reperfusion in rats through endoplasmic reticulum stress and ferroptosis DOI Creative Commons

Xin-Ya Shen,

Xingyu Zhang, Pingping Han

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: March 1, 2024

Abstract Background Repetitive transcranial magnetic stimulation (rTMS) exerts neuroprotective effects early in cerebral ischemia/reperfusion (I/R) injury. Intermittent theta-brust (iTBS), a more time-efficient modality of rTMS, improves the efficiency without at least decreasing efficacy therapy. iTBS elevates cortical excitability, and recent years it has become increasingly common to apply patients post-IS period. However, little is known about mechanisms iTBS. Endoplasmic reticulum stress (ERS), ferroptosis have been shown be involved development I/R We aimed investigate potential regulatory by which attenuates neurological injury after rats. Methods Rats were randomly divided into three groups: sham-operated group, MCAO/R + stimulated with 36 h undergoing middle artery occlusion (MCAO) or sham-operated. The expression ERS, ferroptosis, apoptosis-related markers was subsequently detected western blot assays. also investigated mechanism nerve ischemic reperfusion rats using modified Neurological Severity Score (mNSS) balance beam test measure function. Results performed attenuated levels apoptosis, improved function, including mNSS experiments. It suggested that this mode reduces cost per treatment several times compromising could practical less costly intervention.

Language: Английский

Citations

6
Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways DOI
Qian Zhou, Bin Chen, Yijiao Xu

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 116914 - 116914

Published: July 13, 2023

Language: Английский

Citations

13
Pathological Insights into Cell Death Pathways in Diabetic Wound Healing DOI
Kannan Harithpriya,

Srinivasan Kaussikaa,

Srikanth Kavyashree

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 264, P. 155715 - 155715

Published: Nov. 7, 2024

Language: Английский

Citations

4
Changes in Cell Biology under the Influence of Low-Level Laser Therapy DOI Creative Commons
Piotr Rola, Szymon Włodarczak, Maciej Lesiak

et al.

Photonics, Journal Year: 2022, Volume and Issue: 9(7), P. 502 - 502

Published: July 20, 2022

Low-level laser therapy (LLLT) has become an important part of the therapeutic process in various diseases. However, despite broad use LLLT everyday clinical practice, full impact on cell life processes not been fully understood. This paper presents current state knowledge concerning mechanisms action cells. A better understanding molecular occurring within after irradiation may result introducing numerous novel applications and potentially increases safety profile this therapy.

Language: Английский

Citations

19
The mitigation mechanism of hesperidin on deoxynivalenol toxicity in grass carp hepatocytes via decreasing ROS accumulation and inhibiting JNK phosphorylation DOI
Hao Chen, Xin Chen, Jun Ma

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 134, P. 108646 - 108646

Published: Feb. 25, 2023

Language: Английский

Citations

10
Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury DOI Creative Commons

Zhang-Li Yuan,

Yan-Zi Mo,

De-Li Li

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 14, 2023

Cerebral ischemia-reperfusion injury (CIRI) is the main cause leading to high mortality and neurological disability in patients with cardiac arrest/cardiopulmonary resuscitation (CA/CPR). Our previous study found that extracellular signal-regulated kinase (ERK) activation, dynamin-related protein1 (Drp1)/Mitofusin2 (Mfn2)-dependent mitochondrial dynamics imbalance, excessive autophagy were involved mechanism of nerve after CA/CPR. However, specific pathological signaling pathway still unknown. This aimed explore molecular function changes ERK-Drp1/Mfn2-autophagy SH-SY5Y cell oxygen-glucose deprivation/reoxygenation (OGD/R) model, further clarify pathophysiological CIRI, provide a new strategy for cerebral protection CIRI.SH-SY5Y cells pretreated drugs 24 h before OGD/R. The Drp1 Mfn2 knockdown adopted small interfering RNAs. overexpression p-Drp1S616 used recombinant plasmids. expression levels proteins (p-Drp1, Drp1, Mfn2, Mfn1 Opa1) markers (LC3, Beclin1 p62) measured Western blotting. mRNA transfection determined by PCR. Cell viability evaluated released LDH activity CCK8 assay kits. Mitochondria morphology autophagosome observed under transmission electron microscopy. Mitochondrial was detected permeability transition pore kit. co-expression p-ERK, p-Drp1 LC3 assessed multiple immunofluorescences. One-way analysis variance followed least significance difference post hoc (for equal homogeneity) or Dunnett's T3 test unequal statistical tests.ERK inhibitor-PD98059 (PD) protects from OGD/R-induced injury; while ERK activator-TPA had opposite effect. Similar inhibitor 3-MA, PD downregulated improve viability; activator-rapamycin aggravated death. Drp1-knockdown synergistically attenuated mPTP opening Drp1S616E ablating partly abolished protective effects PD. Multiple immunofluorescences showed co-expressed.Inhibition downregulates via reducing Drp1/Mfn2-dependent fragmentation antagonize dysfunction promotes survival OGD/R model. Video Abstract.

Language: Английский

Citations

10
Ginsenosides Rg1, Rb1 and rare ginsenosides: promising candidate agents for Parkinson's disease and Alzheimer's disease and network pharmacology analysis DOI Creative Commons

Mingchun Jiang,

Jiaxin Chi,

Yifan Qiao

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107578 - 107578

Published: Jan. 5, 2025

Ginseng has been commonly used as a traditional Chinese medicine in Asian countries for thousands of years. Ginsenosides are the main pharmacologically active ingredients isolated from ginseng and have neuroprotective effects treatment neurodegenerative disorders, such Parkinson's disease (PD) Alzheimer's (AD). To summarise investigate protective roles ginsenosides their underlying mechanisms PD AD, we ''Ginsenoside", ''Parkinson's disease", ''Alzheimer's ''anti-inflammatory", ''antioxidant", ''apoptosis" keywords to search extract relevant literature information scientific databases Elsevier, PubMed, Google Scholar databases. In particular, network pharmacology identify potential targets Rg1 Rb1 AD. By analysing existing research advances results, found that ginsenosides, primarily mediated through anti-inflammation, anti-apoptosis anti-oxidative stress, etc, may be associated with PI3K/Akt, BDNF/TrkB, MAPKs, NF-κB, Nrf2 Wnt/β-catenin signalling pathways. This review systematically summarises different Rg1, Rb1, rare AD provides new strategies disorders. Network paradigm using Rb1.

Language: Английский

Citations

0