Signaling Pathways in Neurological Cancers DOI
Meisam Akhlaghdoust, Soheil Tavakolpour, Poorya Davoodi

et al.

Interdisciplinary cancer research, Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 1, 2022

Neural cancer is among the most aggressive and difficult-to-treat malignancies. There are over 100 subtypes of brain tumors, which make this type malignancy even more important. Glioblastoma (GBM) important group them. It associated with a high rate mortality. Due to some difficulties reach tumor for surgeons inefficient penetration medical therapies into blood-brain barrier, it critical have effective specific treatments those patients. One approach could be targeting signaling pathways involved in cancer. Most these essential regular proliferation differentiation cells; however, due mutations one or downstream proteins pathways, they become out control, leads uncontrolled cell proliferation. Additionally, interact each other through different mechanisms. For example, Naked cuticle 1 (NKD1) acts as negative regulator Wnt pathway. In chapter, we covered neural cancers, including Wnt-related cascades key cascade regulating development, related suppressors (e.g., p53), proto-oncogenes PI3K/Akt Signaling), NF-kB-related well JAK-STAT cascades.

Language: Английский

Cellular and molecular mechanisms of Hedgehog signalling DOI
Yunxiao Zhang, Philip A. Beachy

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(9), P. 668 - 687

Published: March 17, 2023

Language: Английский

Citations

102
Cytoneme signaling provides essential contributions to mammalian tissue patterning DOI Creative Commons
Eric T. Hall, Miriam E. Dillard,

Elizabeth R. Cleverdon

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(2), P. 276 - 293.e23

Published: Jan. 1, 2024

During development, morphogens pattern tissues by instructing cell fate across long distances. Directly visualizing morphogen transport in situ has been inaccessible, so the molecular mechanisms ensuring successful delivery remain unclear. To tackle this longstanding problem, we developed a mouse model for compromised sonic hedgehog (SHH) and discovered that endocytic recycling promotes SHH loading into signaling filopodia called cytonemes. We optimized methods to preserve vivo cytonemes advanced microscopy show endogenous localized developing neural tubes. Depletion of from tube alters neuronal fates compromises neurodevelopment. Mutation filopodial motor myosin 10 (MYO10) reduces cytoneme length density, which corrupts activity both WNT. Combined, these results demonstrate cytoneme-based signal provides essential contributions dispersion during mammalian tissue development suggest MYO10 is key regulator function.

Language: Английский

Citations

19
Butterfly pupal wing tissue with an eyespot organizer DOI Creative Commons
Joji M. Otaki, Atsuko Tanaka,

Euichi Hirose

et al.

Cells and Development, Journal Year: 2025, Volume and Issue: unknown, P. 203992 - 203992

Published: Jan. 1, 2025

Language: Английский

Citations

2
Filopodia In Vitro and In Vivo DOI Creative Commons
Thomas C. A. Blake, Jennifer L. Gallop

Annual Review of Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 39(1), P. 307 - 329

Published: July 5, 2023

Filopodia are dynamic cell surface protrusions used for motility, pathogen infection, and tissue development. The molecular mechanisms determining how where filopodia grow retract need to integrate mechanical forces membrane curvature with extracellular signaling the broader state of cytoskeleton. involved actin regulatory machinery nucleates, elongates, bundles filaments separately from underlying cortex. refined geometry filopodia, importance context, high spatiotemporal resolution required, degree redundancy all limit current models. New technologies improving opportunities functional insight, reconstitution in vitro purified components, endogenous genetic modification, inducible perturbation systems, study multicellular environments. In this review, we explore recent advances conceptual models form, molecules process, our latest understanding vivo.

Language: Английский

Citations

25
Neutrophil diversity and function in health and disease DOI Creative Commons

F Zhang,

Yidan Xia,

Jiayang Su

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 5, 2024

Abstract Neutrophils, the most abundant type of granulocyte, are widely recognized as one pivotal contributors to acute inflammatory response. Initially, neutrophils were considered mobile infantry innate immune system, tasked with immediate response invading pathogens. However, recent studies have demonstrated that versatile cells, capable regulating various biological processes and impacting both human health disease. Cytokines other active mediators regulate functional activity by activating multiple receptors on these thereby initiating downstream signal transduction pathways. Dysfunctions in disruptions neutrophil homeostasis been implicated pathogenesis numerous diseases, including cancer disorders, often due aberrant intracellular signaling. This review provides a comprehensive synthesis functions, integrating advancements this field. Moreover, it examines roles signaling pathways involved regulation activity. The pathophysiology diseases emerging therapeutic approaches targeting them also elaborated. addresses current limitations within field research, highlighting critical gaps knowledge warrant further investigation. In summary, seeks establish multidimensional model regulation, providing new perspectives for potential clinical applications research.

Language: Английский

Citations

8
Establishing Hedgehog Gradients during Neural Development DOI Creative Commons
Sara Douceau, Tanya Deutsch Guerrero, Julien Ferent

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(2), P. 225 - 225

Published: Jan. 5, 2023

A morphogen is a signaling molecule that induces specific cellular responses depending on its local concentration. The concept of morphogenic gradients has been central paradigm developmental biology for decades. Sonic Hedgehog (Shh) one the most important morphogens displays pleiotropic functions during embryonic development, ranging from neuronal patterning to axon guidance. It commonly accepted Shh distributed in gradient several tissues different origins development; however, how these are formed and maintained at molecular levels still center great deal research. In this review, we first explored all sources development nervous system. Then, detailed can distribute surrounding via variety mechanisms. Finally, addressed disrupting distribution induce severe neurodevelopmental disorders cancers. Although field neurodevelopment since fifties, also describe contemporary leading-edge techniques, such as organoids, revisit classical model.

Language: Английский

Citations

12
ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles DOI Creative Commons
Erica C. Dresselhaus, Kathryn P. Harris, Cassandra R. Blanchette

et al.

The Journal of Cell Biology, Journal Year: 2024, Volume and Issue: 223(9)

Published: June 6, 2024

Extracellular vesicles (EVs) are released by many cell types, including neurons, carrying cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular or serve primarily to dispose of unwanted materials. We show that loss multivesicular endosome-generating endosomal sorting complex required for transport (ESCRT) machinery disrupts release EV from Drosophila motor neurons. Surprisingly, ESCRT depletion does not affect the activities cargo Synaptotagmin-4 (Syt4) only some evenness interrupted (Evi). Thus, these may require transfer via EVs, instead be conventionally secreted function cell-autonomously neuron. find phagocytosed glia muscles, disruption causes compensatory autophagy presynaptic suggesting one several redundant mechanisms remove synapses. Our results suggest synaptic serves as a proteostatic mechanism certain cargoes.

Language: Английский

Citations

4
The Role of Cytonemes and Diffusive Transport in the Establishment of Morphogen Gradients DOI
Jay A. Stotsky, Hans G. Othmer

Bulletin of Mathematical Biology, Journal Year: 2025, Volume and Issue: 87(2)

Published: Jan. 3, 2025

Language: Английский

Citations

0
Morphogens and Cell-Derived Structures (Exosomes and Cytonemes) as Components of the Communication Between Cells DOI Open Access

Stavros Chideriotis,

Alkmini T. Anastasiadi, Vassilis L. Tzounakas

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 881 - 881

Published: Jan. 21, 2025

Morphogens, which are non-classical transcription factors, according to several studies, display a crucial role in tissue patterning, organ architecture establishment, and human disease pathogenesis. Recent advances have expanded the morphogen participation wide range of diseases. There many genetic syndromes caused by mutations components signaling pathways. The aberrant pathways also promote cancer cell maintenance, renewal, proliferation, migration. On other hand, exosomes their application biomedical field evolving significance. evidence that membrane structures participate creation morphogenic gradience biodistribution renders them attractive as new therapeutic tools. This intercellular transport is performed cell-derived structures, mainly cytonemes, extracellular substances like heparan sulphate proteoglycans lipoproteins. interaction between morphogens Extracellular Vesicles has been observed at first most studied insect, Drosophila, afterwards analogous findings proved vertebrates. review presents protagonists mechanisms lipid-modified (Hedgehog Wnt/β-catenin) biodistribution.

Language: Английский

Citations

0
Slik sculpts the plasma membrane into cytonemes to control cell-cell communication DOI Creative Commons
Basile Rambaud, Mathieu Joseph, Feng‐Ching Tsai

et al.

The EMBO Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Cytonemes are signaling filopodia that facilitate long-range cell-cell communication by forming synapses between cells. Initially discovered in Drosophila for transporting morphogens during embryogenesis, they have since been identified mammalian cells and implicated carcinogenesis. Despite their importance, mechanisms controlling cytoneme biogenesis remain elusive. Here, we demonstrate the Ser/Thr kinase Slik drives remote cell proliferation promoting formation. This function depends on coiled-coil domain of (SlikCCD), which directly sculpts membranes into tubules. Importantly, plays opposing roles biogenesis: its membrane-sculpting activity promotes formation, but this is counteracted activity, enhances actin association with plasma membrane via Moesin phosphorylation. In vivo, SlikCCD formation one epithelial layer wing disc to promote an adjacent layer. Finally, relies STRIPAK complex, controls governs at a distance regulating membrane. Our study unveils unexpected structural role sculpting membranes, crucial cytoneme-mediated control proliferation.

Language: Английский

Citations

0