Design, Synthesis, Antifungal Activity, and 3D-QASR of Novel Oxime Ether-Containing Coumarin Derivatives as Potential Fungicides

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(11), P. 5983 - 5992

Published: March 8, 2024

Structural modification of natural products is an effective approach for improving antifungal activity and has, therefore, been used extensively in the development new agrochemical products. In this work, a series novel coumarin derivatives containing oxime ether structures were designed, synthesized, evaluated activity. Some designed compounds exhibited promising activities against tested fungi, 4a, 4c, 5a, 6b had EC50 values equivalent to those commercial fungicides. Compound was most candidate fungicide Rhizoctonia solani (EC50 = 0.46 μg/mL). vivo bioassays suggested that 5a could serve as agricultural antifungals. Furthermore, microscopy demonstrated compound induced sprawling growth hyphae, distorted outline cell walls, reduced mitochondrial numbers. Additionally, effects substituent steric, electrostatic, hydrophobic, hydrogen-bond fields elucidated using accurate reliable three-dimensional quantitative structure–activity relationship (3D-QSAR) model. The results presented here will guide discovery potential fungicides plant disease control agriculture.

Language: Английский

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Phytochemicals as Antimicrobials: Prospecting Himalayan Medicinal Plants as Source of Alternate Medicine to Combat Antimicrobial Resistance

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(6), P. 881 - 881

Published: June 15, 2023

Among all available antimicrobials, antibiotics hold a prime position in the treatment of infectious diseases. However, emergence antimicrobial resistance (AMR) has posed serious threat to effectiveness antibiotics, resulting increased morbidity, mortality, and escalation healthcare costs causing global health crisis. The overuse misuse setups have accelerated development spread AMR, leading multidrug-resistant (MDR) pathogens, which further limits options. This creates critical need explore alternative approaches combat bacterial infections. Phytochemicals gained attention as potential source medicine address challenge AMR. are structurally functionally diverse multitarget effects, disrupting essential cellular activities. Given promising results plant-based coupled with slow discovery novel it become highly imperative vast repository phytocompounds overcome looming catastrophe review summarizes AMR towards existing potent phytochemicals having activities, along comprehensive overview 123 Himalayan medicinal plants reported possess phytocompounds, thus compiling information that will help researchers exploration

Language: Английский

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Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2839 - 2839

Published: Feb. 2, 2023

This review summarizes and systematizes the literature on anti-HIV activity of plant coumarins with emphasis isolation mechanism their antiviral action. information properties simple as well annulated furano- pyranocoumarins shows that origin can act by several mechanisms: inhibition HIV reverse transcriptase integrase, cellular factors regulate HIV-1 replication, transmission viral particles from infected macrophages to healthy ones. It is important note some are able through mechanisms or bind sites, which ensures resistance these compounds mutations. Here we last two decades research naturally occurring coumarins.

Language: Английский

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Natural Coumarin Derivatives Activating Nrf2 Signaling Pathway as Lead Compounds for the Design and Synthesis of Intestinal Anti-Inflammatory Drugs

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 511 - 511

Published: March 30, 2023

Nrf2 (nuclear factor erythroid 2-related 2) is a transcription related to stress response and cellular homeostasis that plays key role in maintaining the redox system. The imbalance of system triggering for initiation progression non-communicable diseases (NCDs), including Inflammatory Bowel Disease (IBD). its inhibitor Kelch-like ECH-associated protein 1 (Keap1) are main regulators oxidative their activation has been recognized as promising strategy treatment or prevention several acute chronic diseases. Moreover, Nrf2/keap signaling pathway promotes inhibition NF-κB, transcriptional pro-inflammatory cytokines expression, synchronically promoting an anti-inflammatory response. Several natural coumarins have reported potent antioxidant intestinal compounds, acting by different mechanisms, mainly modulator pathway. Based on vivo vitro studies, this review focuses obtained from both plant products fermentative processes food plants gut microbiota, which activate produce activity. Although metabolites urolithin A B well other plant-derived display activity modulating pathway, studies necessary better pharmacological characterization evaluation potential lead compounds. Esculetin, 4-methylesculetin, daphnetin, osthole, imperatorin most coumarin derivatives compounds design synthesis activators with However, further structure–activity relationships experimental models inflammation subsequent clinical trials health disease volunteers essential determine efficacy safety IBD patients.

Language: Английский

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Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis

Phytomedicine, Journal Year: 2023, Volume and Issue: 110, P. 154640 - 154640

Published: Jan. 1, 2023

Language: Английский

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Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(6)

Published: April 8, 2024

Plant-derived coumarin (PDC) is a naturally occurring heterocyclic backbone that belongs to the benzopyrone family. PDC and its based products are characterized by low toxicity high distribution in variety of herbal treatments have numerous therapeutic potentials. These include anticoagulants, antibacterials, anti-inflammatory agents, anticancer antioxidants, others. So, it may be appropriate investigate qualities potential bioactivities PDCs. This article provides an overview biomedical potentials, availability, clinical use possibilities PDCs, with focus on their important modes action, using information various pharmacological discovered. The data used this study came from published research between 2015 2023. We reviewed selection databases, including PubMed, Scopus, Web Science, Google Scholar, during period. In conclusion, because abundance medicinal plants, biochemistry attributes PDCs currently interest. medical specialties, serve useful role as agents.

Language: Английский

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Osthole impairs mitochondrial metabolism and the autophagic flux in colorectal cancer

Phytomedicine, Journal Year: 2024, Volume and Issue: 125, P. 155383 - 155383

Published: Jan. 21, 2024

Language: Английский

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Antibacterial Activity and Mechanism of Action of Osthole against Listeria monocytogenes

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(19), P. 10853 - 10861

Published: May 6, 2024

The purpose of this study was to investigate the antibacterial activity and mechanism action osthole against Listeria monocytogenes. evaluated by determining minimum inhibitory concentration (MIC) growth curve. Cell morphology, membrane permeability, integrity, bacterial physiology, metabolism were explored using different methods elucidate osthole. It shown that MIC L. monocytogenes 62.5 μg/mL it inhibited effectively in a concentration-dependent manner. Scanning electron microscopy (SEM) images demonstrated morphology changes monocytogenes, including rough surface, cell shrinkage, rupture. found extracellular conductivity macromolecule content increased significantly presence osthole, indicating disruption integrity permeability. Laser confocal results supported conclusion caused severe damage membrane. also noticed depleted intracellular adenosine triphosphate (ATP), Na+-K+-ATPase Ca2+-Mg2+-ATPase activity, promoted accumulation reactive oxygen species (ROS), leading death. This suggests is promising agent candidate shows potential prevention control foodborne pathogens.

Language: Английский

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Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3980 - 3980

Published: Aug. 5, 2023

Lung cancer is a heterogeneous group of malignancies with high incidence worldwide. It the most frequently occurring in men and second common women. Due to its frequent diagnosis variable response treatment, lung was reported as top cause cancer-related deaths worldwide 2020. Many aberrant signaling cascades are implicated pathogenesis cancer, including those involved apoptosis (B cell lymphoma protein, Bcl-2-associated X first signal ligand), growth inhibition (tumor suppressor protein or gene serine/threonine kinase 11), promotion (epidermal factor receptor/proto-oncogenes/phosphatidylinositol-3 kinase). Accordingly, these pathways their molecules have become promising targets for chemopreventive chemotherapeutic agents. Recent research provides compelling evidence use plant-based compounds, known collectively phytochemicals, anticancer This review discusses major contributing pathophysiology well currently available treatments prospective drug candidates. The potential naturally bioactive compounds context also discussed, critical analysis mechanistic actions presented by preclinical clinical studies.

Language: Английский

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Signaling Pathways Involved in the Neuroprotective Effect of Osthole: Evidence and Mechanisms

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(2), P. 1100 - 1118

Published: Sept. 8, 2023

Language: Английский

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