Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(8), P. 746 - 746
Published: Aug. 9, 2024
Antibiotic
resistance
emerged
shortly
after
the
discovery
of
first
antibiotic
and
has
remained
a
critical
public
health
issue
ever
since.
Managing
in
clinical
settings
continues
to
be
challenging,
particularly
with
rise
superbugs,
or
bacteria
resistant
multiple
antibiotics,
known
as
multidrug-resistant
(MDR)
bacteria.
This
rapid
development
compelled
researchers
continuously
seek
new
antimicrobial
agents
curb
resistance,
despite
shrinking
pipeline
drugs.
Recently,
focus
shifted
plants,
fungi,
lichens,
endophytes,
various
marine
sources,
such
seaweeds,
corals,
other
microorganisms,
due
their
promising
properties.
For
this
review,
an
extensive
search
was
conducted
across
scientific
databases,
including
PubMed,
Elsevier,
ResearchGate,
Scopus,
Google
Scholar,
encompassing
publications
from
1929
2024.
review
provides
concise
overview
mechanisms
employed
by
develop
followed
in-depth
exploration
plant
secondary
metabolites
potential
solution
MDR
pathogens.
In
recent
years,
interest
plant-based
medicines
surged,
driven
advantageous
However,
additional
research
is
essential
fully
understand
action
verify
safety
phytochemicals.
Future
prospects
for
enhancing
use
combating
antibiotic-resistant
pathogens
will
also
discussed.
Frontiers in Chemistry,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 15, 2025
Microorganisms
are
becoming
resistant
to
drugs
and
antimicrobials,
making
it
a
significantly
critical
global
issue.
Nosocomial
infections
resulting
in
alarmingly
increasing
rates
of
morbidity
mortality.
Plant
derived
compounds
hold
numerous
antimicrobial
properties,
them
very
capable
source
counteract
microbial
strains.
Syzygium
aromaticum
(Clove)
extract
has
been
proven
by
studies
contain
active
ingredients
that
demonstrate
antibacterial,
antifungal,
antioxidant,
insecticidal
properties.
It
also
used
historically
for
its
pain
relief
especially
tooth
ache.
Clove
nanoparticle
synthesis
is
promising
method
combining
therapeutics
with
metals
at
nanoscale.
Such
nanostructured
systems
combination
the
heterocyclic
antibiotic
clarithromycin
could
potentiate
action
plant
extracts,
decrease
drug
side
effects
improve
activity.
In
this
study,
clove
(C)
was
successfully
synthesize
silver
nanoparticles
(AgNP)
create
AgNPC
AgNPCA
(A
=
clarithromycin).
The
two
underwent
different
analytical
methods
consisting
SEM,
EDS,
DLS,
UV-vis,
FTIR
XRD.
These
were
against
variety
10
pathogens
exhibited
good
intermediate
antibacterial
resulted
better
properties
smaller
size.
This
study
demonstrates
potential
mediated
AgNP
without
clarithromycin.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 31, 2023
Antibiotic
resistance
development
and
pathogen
cross-dissemination
are
both
considered
essential
risks
to
human
health
on
a
worldwide
scale.
Antimicrobial
genes
(AMRs)
acquired,
expressed,
disseminated,
traded
mainly
through
integrons,
the
key
players
capable
of
transferring
from
bacterial
chromosomes
plasmids
their
integration
by
integrase
target
pathogenic
host.
Moreover,
integrons
play
central
role
in
disseminating
assembling
connected
with
antibiotic
commensal
species.
They
exhibit
large
concealed
diversity
natural
environment,
raising
concerns
about
potential
for
comprehensive
application
adaptation.
should
be
viewed
as
dangerous
pool
determinants
“One
Health
approach.”
Among
three
documented
classes
reported
viz.,
class-1,
2,
3,
class
1
has
been
found
frequently
associated
AMRs
humans
is
critical
genetic
element
serve
therapeutics
gene
silencing
or
combinatorial
therapies.
The
direct
method
screening
cassettes
linked
pathogenesis
harbored
novel
way
assess
health.
In
last
decade,
they
have
witnessed
surveying
integron-associated
increased
drug
tolerance
rising
pathogenicity
microbes.
Consequently,
we
aimed
unravel
structure
functions
mechanism
understanding
horizontal
transfer
one
trophic
group
another.
Many
updates
related
extensively
explored.
Additionally,
an
updated
account
assessment
prevailing
grossly
detailed—lastly,
estimation
AMR
dissemination
employing
biomarkers
also
highlighted.
current
review
will
pave
clinical
devising
roadmap
solution
pathogenicity.
Graphical
Abstract
graphical
abstract
displays
how
integron-aided
humans:
Transposons
capture
integron
yield
high
mobility
that
res
sites
plasmids.
These
plasmids,
turn,
promote
acquired
into
diverse
acquisitions
resistant
transferred
transfer.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 162 - 162
Published: Jan. 24, 2024
Biofilm
formation
is
considered
one
of
the
primary
virulence
mechanisms
in
Gram-positive
and
Gram-negative
pathogenic
species,
particularly
those
responsible
for
chronic
infections
promoting
bacterial
survival
within
host.
In
recent
years,
there
has
been
a
growing
interest
discovering
new
compounds
capable
inhibiting
biofilm
formation.
This
promising
antivirulence
strategy
that
could
potentially
overcome
antibiotic
resistance
issues.
Effective
antibiofilm
agents
should
possess
distinctive
properties.
They
be
structurally
unique,
enable
easy
entry
into
cells,
influence
quorum
sensing
signaling,
synergize
with
other
antibacterial
agents.
Many
these
properties
are
found
both
natural
systems
isolated
from
plants
synthetic
like
nanoparticles
nanocomposites.
this
review,
we
discuss
clinical
nature
biofilm-associated
some
associated
their
tolerance.
We
focus
on
advantages
efficacy
various
as
therapeutic
approach
to
control
biofilms
address
multidrug
bacteria.
Agronomy,
Journal Year:
2023,
Volume and Issue:
13(8), P. 2063 - 2063
Published: Aug. 4, 2023
The
need
to
meet
food
demand
becomes
more
urgent
as
it
is
forecasted
increase
by
50%
over
the
next
century.
Thus,
agronomists
promote
sensible
tools
and
approaches
eradicate
factors
that
hamper
crop
production,
mainly
weeds.
constant
use
of
chemical
herbicides
control
weeds
leads
an
increased
risk
herbicide-resistant
weed
populations,
environmental
pollution,
unsafe
agricultural
products,
negative
effects
on
human
health.
These
problems
have
caused
interest
among
researchers
replace
synthetic
with
alternatives.
purpose
this
review
was
present
current
knowledge
base
allelopathic
tropical
plants
their
potential
for
in
development
natural
product-based,
environmentally
friendly
sustainable
agriculture,
stimulate
future
discussion
topic.
defence
mechanisms
received
particular
attention
because
ability
a
pesticide
can
prevent
overuse
pesticides.
ancient
toxic
properties
various
gives
us
basis
creating
novel
pest
approach.
synthesis
biopesticides
based
allelochemicals
opens
up
possibility
utilizing
compounds
protection
demonstrates
deal
evolved
resistance.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4949 - 4949
Published: May 1, 2024
Antimicrobial
resistance
(AMR)
poses
an
emanating
threat
to
humanity’s
future.
The
effectiveness
of
commonly
used
antibiotics
against
microbial
infections
is
declining
at
alarming
rate.
As
a
result,
morbidity
and
mortality
rates
are
soaring,
particularly
among
immunocompromised
populations.
Exploring
alternative
solutions,
such
as
medicinal
plants
iodine,
shows
promise
in
combating
resistant
pathogens.
Such
antimicrobials
could
effectively
inhibit
proliferation
through
synergistic
combinations.
In
our
study,
we
prepared
formulation
consisting
Aloe
barbadensis
Miller
(AV),
Thymol,
iodine
(I2),
polyvinylpyrrolidone
(PVP).
Various
analytical
methods
including
SEM/EDS,
UV-vis,
Raman,
FTIR,
XRD
were
carried
out
verify
the
purity,
composition,
morphology
AV-PVP-Thymol-I2.
We
evaluated
inhibitory
effects
this
10
selected
reference
strains
using
impregnated
sterile
discs,
surgical
sutures,
gauze
bandages,
face
masks,
KN95
masks.
antimicrobial
properties
AV-PVP-Thymol-I2
assessed
disc
diffusion
comparison
with
two
common
antibiotics.
25-month-old
exhibited
slightly
lower
zones,
indicating
changes
sustained-iodine-release
reservoir.
Our
findings
confirm
potent
antifungal
antibacterial
agent
strains,
demonstrating
strong
action
on
cotton
These
results
enable
potential
use
promising
wound
spray-on
contact-killing
agent.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(7)
Published: Feb. 1, 2025
Abstract
Water
pollution
from
organic
dye‐based
effluents
is
a
major
environmental
concern
across
the
world.
Zinc
oxide
nanoparticles
(ZnO
NPs)
have
gained
attention
as
an
effective
material
for
degrading
dyes
in
wastewater.
In
this
study,
ZnO
NPs
were
synthesized
through
eco‐friendly
bio‐reduction
process
using
Musa
paradisiaca
plant
latex
both
reducing
and
stabilizing
agent.
Structural
analysis
confirmed
that
single‐phase
hexagonal
crystal
structure
with
size
ranging
15
to
25
nm.
Energy
dispersive
spectroscopic
technique
has
verified
presence
of
zinc
oxygen,
while
high‐resolution
transmission
electron
microscopy
revealed
shaped
particles
average
~20
Under
solar
irradiation,
demonstrated
exceptional
photocatalytic
activity.
They
achieved
91%
degradation
methylene
blue
(MB)
30
minutes
rate
constant
0.08
min‐1.
For
violet
Rhodamine
B
(RhB),
95%
was
90
minutes,
constants
~0.03
A
proposed
3D
reaction
mechanism
used
explain
MB
RhB
pathways.
Additionally,
exhibited
strong
antibacterial
activity
against
Escherichia
coli
Staphylococcus
aureus.
These
results
highlight
potential
bio‐synthesized
wastewater
treatment
biomedical
applications.
