Gas Therapy: Generating, Delivery, and Biomedical Applications

Small Methods, Journal Year: 2024, Volume and Issue: 8(8)

Published: Jan. 9, 2024

Abstract Oxygen (O 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and ) with direct effects, dioxide (CO complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery in situ generation these gases controllable release at site disease has attracted attention to avoid risk gas poisoning improve their performance treating such cancer therapy, cardiovascular bone tissue engineering, wound healing. Stimuli‐responsive gas‐generating sources systems based biomaterials that enable on‐demand promising approaches for precise therapy. This work highlights current advances design development new generate deliver behavior. delivered biomedical applications is then discussed.

Language: Английский

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Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity

Burns & Trauma, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

Abstract Diabetes mellitus, a pervasive chronic metabolic disorder, is often associated with complications such as impaired wound healing. Various factors, most notably vascular deficiency, govern the repair process in diabetic patients, significantly impeding healing; therefore, angiogenesis and its role have emerged important areas of research. This review aims to delve into mechanisms angiogenesis, effects diabetes on association between repair. will ultimately offer valuable guidance regarding ideal timing treatment clinical setting.

Language: Английский

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Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 26, 2025

Abstract Cellular senescence and hypoxia-inducible factor (HIF) signaling are crucial in pulmonary aging age-related lung diseases such as chronic obstructive disease idiopathic fibrosis cancer. HIF plays a pivotal role cellular adaptation to hypoxia, regulating processes like angiogenesis, metabolism, inflammation. Meanwhile, leads irreversible cell cycle arrest, triggering the senescence-associated secretory phenotype which contributes inflammation, tissue remodeling, fibrosis. Dysregulation of these pathways accelerates progression by promoting oxidative stress, mitochondrial dysfunction, epigenetic alterations. Recent studies indicate that interact at multiple levels, where can both induce suppress senescence, depending on conditions. While transient activation supports repair stress resistance, dysregulation exacerbates pathologies. Furthermore, emerging evidence suggests targeting could offer new therapeutic strategies mitigate diseases. This review explores intricate crosstalk between mechanisms, shedding light how their interplay influences progression. Additionally, we discuss potential interventions, including senolytic therapies modulators, enhance health longevity.

Language: Английский

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Catalase-like Nanozyme-Hybrid Hydrogels Utilizing Endogenous ROS as an Oxygen Source To Synergically Regulate Oxidative Stress and Hypoxia for Enhanced Diabetic Wound Healing

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

High levels of reactive oxygen species (ROS) and hypoxia in diabetic wounds significantly hinder the healing process. In this work, a kind catalase-like nanozyme-hybrid hydrogel was developed to explore potential harnessing endogenous excessive ROS as an source synergistically regulate oxidative stress hypoxia, thereby enhancing wound healing. The hydrogels exhibited rapid degradation controlled release ferrihydrite nanozymes response stress, which continuously catalyzed decomposition H2O2 generate oxygen, effectively scavenging reducing risk local toxicity. relieved intracellular hypoxic microenvironment simultaneously vitro. dressings inhibited damage at sites, promoted epidermis formation collagen deposition, accelerated db/db mice. Therefore, represent promising strategy for dressings, addressing both improve outcomes.

Language: Английский

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Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds

Nanoscale, Journal Year: 2022, Volume and Issue: 14(36), P. 12967 - 12983

Published: Jan. 1, 2022

Diabetic wound infection is a common disease that has significantly reduced people's quality of life. Although tremendous achievements have been made in clinical treatment, the crucial challenge diabetic infected management stems from detrimental environment and emergence bacterial resistance after long-term medication, which result efficacy, an increased dosage severe side effects. To tackle these issues, it great significance to develop innovative treatment strategy for therapy. Currently, exploitation nanobiomaterial-based therapeutic systems wounds booming, with stimuli-responsive performance received extensive attention. These are able accelerate healing due on-demand release agents response stimulating factors. Based on characteristics wounds, many endogenous (e.g., glucose, enzyme, hypoxia, acidity) employed targeted patients. Additionally, exogenous stimulants, including light, magnetism, temperature, also capable achieving drug activation. In this review, presented, then exogenous/endogenous stimuli summarized. Finally, current challenges future outlook discussed.

Language: Английский

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Stem Cell-Based Therapy for Diabetic Foot Ulcers

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: Feb. 1, 2022

Diabetic foot ulcer has become a worldwide clinical medical challenge as traditional treatments are not effective enough to reduce the amputation rate. Therefore, it is of great social significance deeply study pathogenesis and biological characteristics diabetic foot, explore new treatment strategies promote their application. Stem cell-based therapy holds tremendous promise in field regenerative medicine, its mechanisms include promoting angiogenesis, ameliorating neuroischemia inflammation, collagen deposition. Studying specific molecular stem cell for an important role practical maximizing repair properties cells. In addition, application modalities also crucial order improve survival viability cells at wound site. this paper, we reviewed extended applications recent years, with aim contributing development ulcers.

Language: Английский

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Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Feb. 15, 2022

Background: Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechanism for the development diabetes complications. Recently, hypoxia has been identified to play an additional pathogenic role in diabetes. In this study, we hypothesized that ROS overproduction was secondary impaired responses due inhibition hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. Methods: The levels were analyzed blood healthy subjects and individuals with type 1 after exposure hypoxia. relation between HIF-1, glucose levels, its functional consequences renal mIMCD-3 cells kidneys mouse models Results: Exposure increased circulating diabetes, but not without High concentrations repressed HIF-1 both hypoxic animals through HIF prolyl-hydroxylase (PHD)-dependent mechanism. signaling contributed excess respiration mediated Pyruvate dehydrogenase kinase (PDK1). restoration function attenuated despite persistent hyperglycemia, conferred protection against apoptosis injury Conclusions: We conclude repression plays potential therapeutic target diabetic These findings are timely since first PHD inhibitor can activate newly approved clinical use. Funding: This work supported grants from Swedish Research Council, Stockholm County Regional Foundation, Bert von Kantzows Society Medicine, Kung Gustaf V:s och Drottning Victorias Frimurarestifelse, Karolinska Institute’s Foundations, Strategic Programme Diabetes, Erling-Persson Family Foundation S-B.C.; Council Heart Lung T.A.S.; ERC consolidator grant M.M.

Language: Английский

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Ultrasmall Coordination Polymer Nanodots Fe‐Quer Nanozymes for Preventing and Delaying the Development and Progression of Diabetic Retinopathy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(36)

Published: April 14, 2023

Abstract Diabetic retinopathy (DR) is the most prevalent type of retinal vasculopathy and widespread cause preventable blindness in adults. Excessive increases reactive oxygen species (ROS) vascular endothelial growth factor are major initiators drivers DR progression, respectively. However, current treatment options remain limited, particularly for early DR. Nanotechnology‐mediated antioxidant strategies gaining increasing popularity to treat ocular diseases. Quercetin has excellent ROS scavenging efficiency but poor stability low bioavailability physiological environments. In this study, ultrasmall Fe‐Quer nanozymes (NZs) formed by coupling quercetin with low‐toxic iron ions reported that can mimic activities three important enzymes, superoxide dismutase, catalase, peroxidase, thereby exhibiting water dispersion efficient ability. vitro vivo assays validate effects NZs against inflammation, oxidative stress damage, microvascular leakage, angiogenesis, their protective effect Transcriptomic analysis further reveals a potential multitarget‐specific therapeutic mechanism These observations open avenues NZs, composed molecules natural product metal artificial NZ activity, as agents other ROS‐related

Language: Английский

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Biological macromolecules-based nanoformulation in improving wound healing and bacterial biofilm-associated infection: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 247, P. 125636 - 125636

Published: June 29, 2023

Language: Английский

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Biomimetic Hydrogel Containing Copper Sulfide Nanoparticles and Deferoxamine for Photothermal Therapy of Infected Diabetic Wounds

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(8)

Published: Dec. 8, 2023

Abstract Inducing cell migration from the edges to center of a wound, promoting angiogenesis, and controlling bacterial infection are very important for diabetic wound healing. Incorporating growth factors antibiotics into hydrogels dressing is considered potential strategy meet these requirements. However, some present drawbacks greatly slow down their development toward application, such as short half‐life high price factors, low antibiotic efficiency against drug‐resistant bacteria, insufficient ability promote migration, etc. Deferoxamine (DFO) can upregulate expression HIF‐1α, thus stimulating secretion angiogenesis‐related endogenous factors. Copper sulfide (CuS) nanoparticles possess excellent antibacterial performance combined with photothermal therapy (PTT). Herein, DFO CuS incorporated biomimetic hydrogel, which mimics structure function extracellular matrix (ECM), abbreviated DFO/CuS‐ECMgel. This hydrogel expected be able adhesion degraded by cell‐secreted metalloproteinases (MMPs), then release at site exert therapeutic effects. As result, three crucial requirements healing, “beneficial effectively killing bacteria,” achieved simultaneously.

Language: Английский

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