Exercise metabolism and adaptation in skeletal muscle

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(9), P. 607 - 632

Published: May 24, 2023

Language: Английский

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Treating NASH by targeting peroxisome proliferator-activated receptors

Journal of Hepatology, Journal Year: 2023, Volume and Issue: 79(5), P. 1302 - 1316

Published: July 17, 2023

Language: Английский

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Timing of Moderate to Vigorous Physical Activity, Mortality, Cardiovascular Disease, and Microvascular Disease in Adults With Obesity

Diabetes Care, Journal Year: 2024, Volume and Issue: 47(5), P. 890 - 897

Published: April 9, 2024

To assess the association between timing of aerobic moderate to vigorous physical activity (MVPA) and risk cardiovascular disease (CVD), microvascular (MVD), all-cause mortality in adults with obesity a subset type 2 diabetes (T2D).

Language: Английский

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Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial

Diabetes Care, Journal Year: 2023, Volume and Issue: 46(7), P. 1417 - 1424

Published: May 25, 2023

OBJECTIVE We aimed to determine the association of time-of-day bout-related moderate-to-vigorous physical activity (bMVPA) with changes in glycemic control across 4 years adults overweight/obesity and type 2 diabetes. RESEARCH DESIGN AND METHODS Among 2,416 participants (57% women; mean age, 59 years) 7-day waist-worn accelerometry recording at year 1 or 4, we assigned bMVPA timing groups based on participants’ temporal distribution recategorized them 4. The time-varying exposure (≥10-min bout) was defined as ≥50% occurring during same time period (morning, midday, afternoon, evening), <50% any (mixed), ≤1 day per week (inactive). RESULTS HbA1c reduction varied among (P = 0.02), independent weekly volume intensity. afternoon group had greatest versus inactive (−0.22% [95%CI −0.39%, −0.06%]), magnitude which 30–50% larger than other groups. odds discontinuation maintaining initiating glucose-lowering medications differed by 0.04). highest (odds ratio 2.13 [95% CI 1.29, 3.52]). For all year-4 groups, there were no significant between CONCLUSIONS performed is associated improvements diabetes, especially within initial 12 months an intervention. Experimental studies are needed examine causality.

Language: Английский

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Circadian desynchrony and glucose metabolism

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(4)

Published: May 1, 2024

Abstract The circadian timing system controls glucose metabolism in a time‐of‐day dependent manner. In mammals, the consists of main central clock bilateral suprachiasmatic nucleus (SCN) anterior hypothalamus and subordinate clocks peripheral tissues. oscillations produced by these different with period approximately 24‐h are generated transcriptional‐translational feedback loops set core genes. Glucose homeostasis is one daily rhythms controlled this system. pacemaker SCN through its neural projections to hypothalamic hubs that control feeding behavior energy metabolism. Using hormones such as adrenal glucocorticoids melatonin autonomic nervous system, modulates critical processes production insulin sensitivity. Peripheral tissues, liver, muscle, adipose tissue serve enhance sustain signals. optimal situation all synchronized aligned environmental light/dark cycle. A negative impact on becomes apparent when internal disturbed, also known desynchrony or misalignment. Circadian may occur at several levels, mistiming light exposure sleep will especially affect clock, whereas food intake physical activity involve clocks. review, we summarize literature investigating how it result development resistance. addition, discuss potential strategies aimed reinstating synchrony improve sensitivity contribute prevention type 2 diabetes.

Language: Английский

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Diurnal timing of physical activity in relation to obesity and diabetes in the German National Cohort (NAKO)

International Journal of Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

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Association between timing and consistency of physical activity and type 2 diabetes: a cohort study on participants of the UK Biobank

Diabetologia, Journal Year: 2023, Volume and Issue: 66(12), P. 2275 - 2282

Published: Sept. 20, 2023

Abstract Aims/hypothesis We sought to quantify the relationship between morning, afternoon or evening physical activity and consistency (e.g. routine) risk of type 2 diabetes. Methods A cohort 93,095 UK Biobank participants (mean age 62 years) without a history diabetes wore wrist-worn accelerometer for 1 week. converted information estimate metabolic equivalent task (MET), summing MET h total completed within three intra-day time segments (morning, evening). quantified as SD participants’ daily activity. ultimately associated each following with incident diabetes: (1) ‘time-segmented’ per week; (2) consistency. also considered moderate-to-vigorous (MVPA) vigorous (VPA) in association incidence. Results When considering measure, we observed protective associations morning (HR 0.90 [95% CI 0.86, 0.93], p =7×10 −8 ) 0.91 0.87, 0.95], =1×10 −5 but did not have evidence 0.95 0.90, 1.00], =0.07) There was no difference MET-measured Our substitution model highlighted importance adjusting lifestyle factors sleep diet); effect attenuated after adjustment variables. Consistency ( =0.07). MVPA VPA were decreased at all times day. Conclusions/interpretation Total equivalents had on play role decreasing Vigorous is lower matter day Graphical

Language: Английский

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Impact of lifestyle moderate‐to‐vigorous physical activity timing on glycemic control in sedentary adults with overweight/obesity and metabolic impairments

Obesity, Journal Year: 2024, Volume and Issue: 32(8), P. 1465 - 1473

Published: June 10, 2024

Moderate-to-vigorous physical activity (MVPA) improves glucose levels; however, whether its timing affects daily glycemic control remains unclear. This study aims to investigate the impact of lifestyle MVPA on in sedentary adults with overweight/obesity and metabolic impairments.

Language: Английский

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Metabolic Adaptations to Morning Versus Afternoon Training: A Systematic Review and Meta-analysis

Sports Medicine, Journal Year: 2023, Volume and Issue: 53(10), P. 1951 - 1961

Published: July 17, 2023

Language: Английский

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Efficacy of morning versus afternoon aerobic exercise training on reducing metabolic syndrome components: A randomized controlled trial

The Journal of Physiology, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 28, 2023

A supervised intense aerobic exercise program improves the health of individuals with metabolic syndrome (MetS). However, it is unclear whether timing training within 24 h day would influence those benefits. The present study aimed to determine morning vs. afternoon on body composition, cardiometabolic and components MetS. One hundred thirty-nine MetS were block randomized into (AMEX; n = 42) or (PMEX; 59) groups, a non-training control group (Control; 38). Exercise was comprised 48 high-intensity interval sessions distributed over 16 weeks. Body cardiorespiratory fitness (assessed by V̇O2max${\dot V_{{{\mathrm{O}}_{\mathrm{2}}}{\mathrm{max}}}}$ ), maximal fat oxidation (FOmax blood pressure metabolites assessed before after intervention. Compared Control, both groups improved similarly composition (-0.7% loss; P 0.002), waist circumference (-2.1 cm; < 0.001), diastolic (-3.8 mmHg; 0.004) (3.5 mL kg-1 min-1 ; 0.001) no differences between groups. AMEX, in comparison PMEX, reduced systolic (-4% -1%; 0.019), plasma fasting insulin concentration (-12% -5%; resistance (-14% -4%; 0.006). Furthermore, Z score further AMEX compared PMEX (-52% -19%; 0.021) training. In summary, somewhat more efficient at reducing risk factors (i.e. sensitivity). KEY POINTS: effect time promotion an area that has gained interest recent years; however, large-scale, randomized-control studies are scarce. People (MetS) developing diseases reductions this can be precisely gauged using compound sensitive subtle evolution each component score). Supervised for weeks (morning afternoon), without dietary restriction, fitness, mean arterial non-exercise group. morning, changes dose intensity, when afternoon. Thus, improving syndrome.

Language: Английский

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