Diabetes Obesity and Metabolism,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Abstract
Aims
TCF7L2
rs7903146
is
the
most
impactful
single
genetic
risk
variant
for
type
2
diabetes.
However,
its
role
on
disease
progression,
complications
and
mortality
among
people
with
diabetes
at
diagnosis
remains
unclear.
Materials
Methods
We
assessed
per
allele
impact
of
T‐allele
clinical
characteristics
complication
in
9231
individuals
over
a
10‐year
follow‐up
period.
Log‐binomial
robust
Poisson
regression
analyses
were
used
to
estimate
prevalence
ratios
macro‐
microvascular
onset,
while
Cox
was
applied
post‐diagnosis.
Analyses
adjusted
sex,
calendar
year
birth,
age
enrollment
duration.
Results
The
associated
0.6
kg/m
(95%
CI:
0.4,
0.8)
lower
BMI,
1.4
cm
1.0,
1.8)
smaller
waist
circumference,
5.6%
4.2,
7.0)
insulin
secretion
5.0%
3.3,
6.7)
higher
sensitivity.
Over
10
years,
risks
major
adverse
cardiovascular
events
(0.87
[95%
CI
0.79,
0.95]),
myocardial
infarction
(0.82
0.72,
0.93])
heart
failure
(0.85
0.73,
1.00]),
no
significant
complications.
Conclusions
less
obesity,
action
decreased
following
onset.
Metabolism,
Journal Year:
2024,
Volume and Issue:
152, P. 155786 - 155786
Published: Jan. 10, 2024
Diabetes
presents
a
pressing
healthcare
crisis,
necessitating
innovative
solutions.
Organoid
technologies
have
rapidly
advanced,
leading
to
the
emergence
of
bioengineering
islet
organoids
as
an
unlimited
source
insulin-producing
cells
for
treating
insulin-dependent
diabetes.
This
advancement
surpasses
need
cadaveric
transplantation.
However,
clinical
translation
this
approach
faces
two
major
limitations:
immature
endocrine
function
and
absence
perfusable
vasculature
compared
primary
human
islets.
In
review,
we
summarize
latest
developments
in
functional
vitro
promoting
vascularization
organoid
grafts
before
after
We
highlight
crucial
roles
ensuring
long-term
survival,
maturation,
functionality
organoids.
Additionally,
discuss
key
considerations
that
must
be
addressed
organoid-based
therapy,
including
immaturity,
undesired
heterogeneity,
potential
tumorigenic
risks.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(8)
Published: April 1, 2024
Abstract
The
objective
of
this
study
was
to
examine
the
association
between
serum
copper
concentration
and
prevalence
diabetes
among
US
adults
with
hypertension
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
population
selected
aged
over
20
years
old
in
three
survey
cycles
NHANES
2011
2016.
Logistic
regression
model
analyses
were
applied
determine
independent
risky
effect
diabetes.
Also,
a
restricted
cubic
spline
(RCS)
performed
explore
potential
nonlinear
A
total
1786
subjects
(742
cases
1044
controls)
included,
924
men
(51.7%),
742
(41.5%)
diabetic.
Compared
non‐diabetic
individuals,
diabetic
patients
higher.
After
adjusting
for
age,
sex,
race,
education,
marital
status,
body
mass
index
(BMI),
family
poverty
income
ratio
(PIR),
smoking,
alcohol
drinking,
physical
activity,
systolic
blood
pressure
(SBP),
diastolic
(DBP),
hyperlipidemia,
highest
quartile
significantly
increased
risk
as
compared
lowest
(OR:
1.38,
95%
CI:
1.01–1.92,
p
trend
=
0.036).
results
RCS
analysis
showed
significant
non‐linear
relationship
(
‐non‐linear
0.010).
This
finds
that
are
associated
hypertensive
patients,
which
suggests
an
important
factor
development.
Background:
Uric
acid
(UA)
levels
have
been
associated
with
several
systemic
diseases,
but
uncertainty
remians
regarding
their
associations
diabetic
microvascular
complications.
This
study
aimed
to
identify
genetic
causal
between
UA
and
Nucleosides Nucleotides & Nucleic Acids,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 10
Published: Jan. 17, 2025
Objective
Type
2
Diabetes
Mellitus
(T2DM)
can
lead
to
long-term
vascular
complications
such
as
diabetic
peripheral
neuropathy
(DPN).
This
study
aimed
investigate
the
role
of
angiotensin-converting
enzyme
(ACE)
insertion
(I)/deletion
(D)
and
angiotensin
II
type
1
receptor
(AT1R)
A1166C
variants
in
predisposition
T2DM
Turkish
population
their
association
with
DPN.
Vavilov Journal of Genetics and Breeding,
Journal Year:
2025,
Volume and Issue:
28(8), P. 1008 - 1017
Published: Jan. 26, 2025
Data
on
the
genetics
and
molecular
biology
of
diabetes
are
accumulating
rapidly.
This
poses
challenge
creating
research
tools
for
a
rapid
search
for,
structuring
analysis
information
in
this
field.
We
have
developed
web
resource,
GlucoGenes
®
,
which
includes
database
an
Internet
portal
genes
proteins
associated
with
high
glucose
(hyperglycemia),
low
(hypoglycemia),
both
metabolic
disorders.
The
data
were
collected
using
text
mining
publications
indexed
PubMed
Central
gene
networks
hyperglycemia,
hypoglycemia
variability
performed
ANDSystems,
bioinformatics
tool.
is
freely
available
at:
https://glucogenes.sysbio.ru/genes/main.
enables
users
to
access
download
about
risk
hyperglycemia
hypoglycemia,
regulators
hyperglycemic
antihyperglycemic
activity,
up-regulated
by
and/or
glucose,
down-regulated
molecules
otherwise
metabolism
With
evolutionary
disorders
was
performed.
results
revealed
significant
increase
(up
40
%)
proportion
phylostratigraphic
age
index
(PAI)
values
corresponding
time
origin
multicellular
organisms.
Analysis
sequence
conservation
divergence
(DI)
showed
that
most
highly
conserved
(DI
<
0.6)
or
conservative
1).
When
analyzing
single
nucleotide
polymorphism
(SNP)
proximal
regions
promoters
affecting
affinity
TATA-binding
protein,
181
SNP
markers
found
database,
can
reduce
(45
markers)
(136
expression
52
genes.
believe
resource
will
be
useful
tool
further
field
diabetes.
