Exercise, exerkines and exercise mimetic drugs: Molecular mechanisms and therapeutics DOI

Vedant Samant,

Arati Prabhu

Life Sciences, Journal Year: 2024, Volume and Issue: 359, P. 123225 - 123225

Published: Nov. 9, 2024

Language: Английский

Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit DOI Creative Commons

Bandar Alharbi,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: March 27, 2024

Abstract Parkinson's disease (PD) is a progressive neurodegenerative as result of the degeneration dopaminergic neurons in substantia nigra pars compacta (SNpc). The fundamental features PD are motor and non-motor symptoms. symptoms develop due to disruption neurotransmitters other such γ-aminobutyric acid (GABA). potential role GABA neuropathology concerning was not precisely discussed. Therefore, this review intended illustrate possible regarding pathway essential regulating inhibitory tone prevent excessive stimulation cerebral cortex. Degeneration linked with reducing GABAergic neurotransmission. Decreasing activity promotes mitochondrial dysfunction oxidative stress, which highly related neuropathology. Hence, restoring by agonists may attenuate progression dysregulation SNpc contributes developing Besides, also pathway, amelioration reduce In conclusion, deregulation might be intricate Improving novel, beneficial approach control

Language: Английский

Citations

16
Defective autophagy and autophagy activators in myasthenia gravis: a rare entity and unusual scenario DOI
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Majid S. Jabir

et al.

Autophagy, Journal Year: 2024, Volume and Issue: 20(7), P. 1473 - 1482

Published: Feb. 12, 2024

Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) that results from autoantibodies against nicotinic acetylcholine receptors (nAchRs) at NMJs. These are mainly originated autoreactive B cells bind and destroy nAchRs NMJs preventing nerve impulses activating end-plates skeletal muscle. Indeed, immune dysregulation plays a crucial role in pathogenesis MG. Autoreactive increased MG due to defect central peripheral tolerance mechanisms. As well, T augmented diversion regulatory (T

Language: Английский

Citations

13
Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue DOI Creative Commons
Areej Turkistani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 7092 - 7108

Published: Feb. 17, 2024

Abstract Parkinson’s disease (PD) is a progressive neurodegenerative of the brain due to degeneration dopaminergic neurons in substantia nigra (SN). Glycogen synthase kinase 3 beta (GSK-3β) implicated pathogenesis PD. Therefore, purpose present review was revise mechanistic role GSK-3β PD neuropathology, and how inhibitors affect neuropathology. GSK-3 conserved threonine/serine protein that intricate regulation cellular anabolic catabolic pathways by modulating glycogen synthase. Over-expression also interconnected with development different diseases. However, underlying mechanism neuropathology not fully clarified. induces triggering mitochondrial dysfunction oxidative stress SN. NF-κB NLRP3 inflammasome are activated response dysregulated leading neuronal injury. Higher expression early stages might contribute reduction neuroprotective brain-derived neurotrophic factor (BDNF). Thus, may be effective reducing inflammatory disorders which associated

Language: Английский

Citations

12
Role of fenofibrate in multiple sclerosis DOI Creative Commons
Ahmad Abulaban, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Feb. 9, 2024

Abstract Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of central nervous system (CNS). The underlying pathophysiology MS destruction myelin sheath by immune cells. formation plaques, inflammation, injury neuronal characterizes its neuropathology. plaques are multiple focal regions demyelination disseminated in brain's white matter, spinal cords, deep grey cerebral cortex. Fenofibrate a peroxisome proliferative activated receptor alpha (PPAR-α) that attenuates reactions MS. inhibits differentiation Th17 inhibiting expression pro-inflammatory signaling. According to these findings, this review intended illuminate mechanistic immunoinflammatory role fenofibrate mitigating In conclusion, can attenuate neuropathology modulating different pathways, including oxidative stress, autophagy, mitochondrial dysfunction, inflammatory-signaling neuroinflammation.

Language: Английский

Citations

11
The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon DOI
Hayder M. Al‐kuraishy,

Sadiq M. Al‐Hamash,

Majid S. Jabir

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102200 - 102200

Published: Jan. 17, 2024

Language: Английский

Citations

10
Irisin's emerging role in Parkinson's disease research: A review from molecular mechanisms to therapeutic prospects DOI Creative Commons

Ruqing Qiu,

Weilu Sun,

Yana Su

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123088 - 123088

Published: Sept. 30, 2024

Language: Английский

Citations

6
Dysregulation of serotonergic neurotransmission in Parkinson disease: A key duet DOI Creative Commons
Manal M. Khowdiary, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177419 - 177419

Published: Feb. 1, 2025

Language: Английский

Citations

0
The role of irisin in exercise-induced muscle and metabolic health: a narrative review DOI

Sumaya Nadhim Mohammed,

Mohannad Hamid Jasim,

Shahad Hisham Mahmood

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Glutamatergic dysfunction in neurodegenerative diseases focusing on Parkinson's disease: Role of glutamate modulators DOI Creative Commons
Najlaa H. Almohmadi, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111349 - 111349

Published: April 1, 2025

Language: Английский

Citations

0
Plasma BDNF/Irisin Ratio Associates with Cognitive Function in Older People DOI
Xiuxiu Huang, Jiaxin Wang, Shifang Zhang

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(4), P. 1261 - 1271

Published: May 23, 2024

Background: Reliable blood biomarkers are crucial for early detection and treatment evaluation of cognitive impairment, including Alzheimer’s disease other dementias. Objective: To examine whether plasma their combination different between older people with mild impairment (MCI) cognitively normal individuals, to explore relations performance. Methods: This cross-sectional study included 250 adults, 124 participants MCI, 126 participants. Plasma brain-derived neurotrophic factor (BDNF), irisin clusterin were measured, BDNF/irisin ratio was calculated. Global cognition evaluated by the Montreal Cognitive Assessment. Results: levels, but not BDNF, significantly MCI group group. Higher concentration associated an increased probability both before after controlling covariates. By contrast, BDNF concentration, irisin, linearly correlated performance adjusting ratios only better performance, also lower risks no matter we adjusted concentrations aging, whereas remained stable. No significant results observed. Conclusions: may be a reliable indicator which reflects odds presence directly associates

Language: Английский

Citations

3