LncRNAs in necroptosis: Deciphering their role in cancer pathogenesis and therapy DOI
Rahamat Unissa Syed, Selim Afşar,

Nayla Ahmed Mohammed Aboshouk

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155252 - 155252

Published: March 5, 2024

Language: Английский

Targeting notch-related lncRNAs in cancer: Insights into molecular regulation and therapeutic potential DOI

Raihan Siddique,

Gaurav Gupta,

Johar MGM

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 257, P. 155282 - 155282

Published: April 1, 2024

Language: Английский

Citations

7
Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis DOI
Asif Ahmad Bhat, Yassine Riadi, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155224 - 155224

Published: Feb. 23, 2024

Language: Английский

Citations

6
Harnessing Pyroptosis for Lung Cancer Therapy: The Impact of NLRP3 Inflammasome Activation DOI
Rajiv Dahiya, Vijaykumar Sutariya, Sheeba Varghese Gupta

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155444 - 155444

Published: Aug. 1, 2024

Language: Английский

Citations

4
MicroRNA-21 (miR-21) in Breast Cancer: From Apoptosis Dysregulation to Therapeutic Opportunities DOI
Rahamat Unissa Syed,

Humera Banu,

Alia Alshammrani

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155572 - 155572

Published: Aug. 30, 2024

Language: Английский

Citations

4
Pathological Interplay of NF-κB and M1 Macrophages in Chronic Inflammatory Lung Diseases DOI
Fadiyah Jadid Alanazi,

Abeer Nuwayfi Alruwaili,

Nouf Afit Aldhafeeri

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155903 - 155903

Published: March 7, 2025

Language: Английский

Citations

0
MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance DOI
Ahsas Goyal, Muhammad Afzal,

Kavita Goyal

et al.

Regenerative Therapy, Journal Year: 2025, Volume and Issue: 29, P. 303 - 318

Published: April 5, 2025

Language: Английский

Citations

0
circ-0001454 alleviates asthma airway inflammation and remodeling via sponging miR-770-5p and regulating cbl-b DOI Creative Commons

Ruobai Liu,

Yilan Song,

Zhiguang Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 8, 2025

Bronchial asthma is a chronic inflammatory disease that has long been severe threat to human physical and mental health. Circular RNAs (circRNAs) microRNAs (miRNAs) are involved in regulating various processes asthma. However, the mechanisms by which these molecules influence pathophysiological of through target gene regulation remain unclear. Our study found inhibition miR-770-5p alleviated airway inflammation remodeling asthmatic mice. Furthermore, bioinformatics analysis revealed circ-0001454 harbors binding sites for miR-770-5p, acting as sponge adsorb function competing endogenous RNA (ceRNA), thereby negatively expression miR-770-5p. Circ-0001454 not only mice, but also participated modulating HDM-induced response BEAS-2B cells. It mitigated bronchial epithelial cell damage, reduced oxidative stress, apoptosis, mitochondrial membrane potential loss. Mechanistically, we observed partially damage cells caused overexpression excessive reactive oxygen species (ROS) production, disruption. Lastly, targets participates cbl-b, turn modulates levels EGFR, AKT1, MAPK1 proteins, alleviating These findings reveal role asthma, how circ-0001454, targeting contributes attenuation inflammation, reduction ROS levels, restoration potential. This suggests new therapeutic treatment.

Language: Английский

Citations

0
lncRNAs and cyclin-dependent kinases: Unveiling their critical roles in cancer progression DOI

Raihan Siddique,

Lakshmi Thangavelu,

S RenukaJyothi

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 258, P. 155333 - 155333

Published: April 27, 2024

Language: Английский

Citations

3
Tau proteins and senescent Cells: Targeting aging pathways in Alzheimer’s disease DOI
Mahaveer Singh,

Haider Ali,

S. Renuka Jyothi

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1844, P. 149165 - 149165

Published: Aug. 22, 2024

Language: Английский

Citations

3
The Impact of NF-κB on Inflammatory and Angiogenic Processes in Age-Related Macular Degeneration DOI
Waleed Hassan Almalki, Salem Salman Almujri

Experimental Eye Research, Journal Year: 2024, Volume and Issue: 248, P. 110111 - 110111

Published: Sept. 24, 2024

Language: Английский

Citations

3