Neuroplasticity in the mesolimbic dopamine system and cocaine addiction

British Journal of Pharmacology, Journal Year: 2008, Volume and Issue: 154(2), P. 327 - 342

Published: March 17, 2008

The main characteristics of cocaine addiction are compulsive drug use despite adverse consequences and high rates relapse during periods abstinence. A current popular hypothesis is that due to drug-induced neuroadaptations in reward-related learning memory processes, which cause hypersensitivity cocaine-associated cues, impulsive decision making abnormal habit-like learned behaviours insensitive consequences. Here, we review results from studies on the effect exposure selected signalling cascades, growth factors physiological processes previously implicated neuroplasticity underlying normal memory. These include extracellular signal-regulated kinase (ERK) pathway, brain-derived neurotrophic factor (BDNF), glutamate transmission, synaptic plasticity (primarily form long-term potentiation depression, LTP LTD). We also discuss degree these cocaine-induced changes mesolimbic dopamine system mediate psychomotor sensitization cocaine-seeking behaviours, as assessed animal models addiction. Finally, speculate how may interact initiate sustain seeking.

Language: Английский

---

Context-induced relapse to drug seeking: a review

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2008, Volume and Issue: 363(1507), P. 3233 - 3243

Published: July 18, 2008

In humans, exposure to environmental contexts previously associated with drug intake often provokes relapse use, but the mechanisms mediating this are unknown. Based on early studies by Bouton & Bolles context-induced 'renewal' of learned behaviours, we developed a procedure study seeking. procedure, rats first trained self-administer in one context. Next, drug-reinforced lever responding is extinguished different (non-drug) Subsequently, reinstatement seeking assessed re-exposing drug-associated Using variations and others reported reliable history heroin, cocaine, heroin-cocaine combination, alcohol nicotine self-administration. Here, discuss potential psychological reinstatement, including excitatory inhibitory Pavlovian conditioning, occasion setting. We then summarize results from pharmacological neuroanatomical role several neurotransmitter systems (dopamine, glutamate, serotonin opioids) brain areas (ventral tegmental area, accumbens shell, dorsal striatum, basolateral amygdala, prefrontal cortex, hippocampus lateral hypothalamus) reinstatement. conclude discussing clinical implications rat

Language: Английский

---

Glutamatergic substrates of drug addiction and alcoholism

Biochemical Pharmacology, Journal Year: 2007, Volume and Issue: 75(1), P. 218 - 265

Published: July 2, 2007

Language: Английский

---

The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research

Psychopharmacology, Journal Year: 2013, Volume and Issue: 229(3), P. 453 - 476

Published: May 17, 2013

Language: Английский

---

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

Neuropsychopharmacology, Journal Year: 2015, Volume and Issue: 41(1), P. 335 - 356

Published: May 15, 2015

Language: Английский

---

Addiction and Brain Reward and Antireward Pathways

Advances in psychosomatic medicine, Journal Year: 2011, Volume and Issue: unknown, P. 22 - 60

Published: Jan. 1, 2011

Addictive drugs have in common that they are voluntarily self-administered by laboratory animals (usually avidly), and enhance the functioning of reward circuitry brain (producing 'high' drug user seeks). The core consists an 'in-series' circuit linking ventral tegmental area, nucleus accumbens pallidum via medial forebrain bundle. Although originally believed to simply encode set point hedonic tone, these circuits now be functionally far more complex, also encoding attention, expectancy reward, disconfirmation expectancy, incentive motivation. 'Hedonic dysregulation' within may lead addiction. 'second-stage' dopaminergic component this is crucial addictive-drug-sensitive component. All addictive (directly or indirectly even transsynaptically) dop-aminergic synaptic function accumbens. Drug self-administration regulated dopamine levels, done keep a specific elevated range (to maintain desired level). For some classes (e.g. opiates), tolerance euphoric effects develops with chronic use. Postuse dysphoria then comes dominate addicts no longer use get high, but back normal ('get straight'). mediating pleasurable anatomically, neurophysiologically neurochemically different from those physical dependence, craving relapse. There important genetic variations vulnerability addiction, yet environmental factors such as stress social defeat alter brain-reward mechanisms manner impart In short, 'bio-psycho-social' model etiology holds very well for Addiction appears correlate hypodopaminergic dysfunctional state brain. Neuroimaging studies humans add credence hypothesis. Credible evidence implicates serotonergic, opioid, endocannabinoid, GABAergic glutamatergic Critically, addiction progresses occasional recreational impulsive habitual compulsive This correlates progression reward-driven habit-driven drug-seeking behavior. behavioral neuroanatomical striatal (nucleus accumbens) dorsal control over three classical sets relapse triggers (a) reexposure drugs, (b) stress, (c) cues (people, places, things) previously associated drug-taking Drug-triggered involves neurotransmitter dopamine. Stress-triggered central amygdala, bed stria terminalis, corticotrophin-releasing factor, lateral noradrenergic nuclei stem norepinephrine. Cue-triggered basolateral hippocampus glutamate. Knowledge neuroanatomy, neurophysiology, neurochemistry neuropharmacology action currently producing variety strategies pharmacotherapeutic treatment which appear promising.

Language: Английский

---

The ins and outs of the striatum: Role in drug addiction

Neuroscience, Journal Year: 2015, Volume and Issue: 301, P. 529 - 541

Published: June 24, 2015

Language: Английский

---

Animal models of drug relapse and craving

Progress in brain research, Journal Year: 2015, Volume and Issue: unknown, P. 25 - 52

Published: Nov. 5, 2015

Language: Английский

---

The Role of Orbitofrontal Cortex in Drug Addiction: A Review of Preclinical Studies

Biological Psychiatry, Journal Year: 2007, Volume and Issue: 63(3), P. 256 - 262

Published: Aug. 24, 2007

Language: Английский

---

Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories – indications for novel treatments of addiction

European Journal of Neuroscience, Journal Year: 2014, Volume and Issue: 40(1), P. 2163 - 2182

Published: June 17, 2014

Abstract This review discusses the evidence for hypothesis that development of drug addiction can be understood in terms interactions between Pavlovian and instrumental learning memory mechanisms brain underlie seeking taking drugs. It is argued these behaviours initially are goal‐directed, but increasingly become elicited as stimulus–response habits by drug‐associated conditioned stimuli established conditioning. further compulsive use emerges result a loss prefrontal cortical inhibitory control over habits. Data reviewed indicate transitions from to abuse depend upon shifts ventral dorsal striatal behaviour, mediated part serial connectivity striatum midbrain dopamine systems. Only some individuals lose their use, importance behavioural impulsivity vulnerability trait predicting stimulant animals humans, together with consideration an emerging neuroendophenotype discussed. Finally, potential developing treatments considered light neuropsychological advances reviewed, including possibility targeting reconsolidation extinction reduce influences on means promoting abstinence preventing relapse.

Language: Английский

---