The Brain on Drugs: From Reward to Addiction

Cell, Journal Year: 2015, Volume and Issue: 162(4), P. 712 - 725

Published: Aug. 1, 2015

Language: Английский

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Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

Neuropsychopharmacology, Journal Year: 2015, Volume and Issue: 41(1), P. 335 - 356

Published: May 15, 2015

Language: Английский

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The ins and outs of the striatum: Role in drug addiction

Neuroscience, Journal Year: 2015, Volume and Issue: 301, P. 529 - 541

Published: June 24, 2015

Language: Английский

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Synaptic mechanisms underlying persistent cocaine craving

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(6), P. 351 - 365

Published: May 6, 2016

Language: Английский

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Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections

Neuron, Journal Year: 2014, Volume and Issue: 83(6), P. 1453 - 1467

Published: Sept. 1, 2014

Language: Английский

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Animal models of drug relapse and craving

Progress in brain research, Journal Year: 2015, Volume and Issue: unknown, P. 25 - 52

Published: Nov. 5, 2015

Language: Английский

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Volitional social interaction prevents drug addiction in rat models

Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(11), P. 1520 - 1529

Published: Oct. 11, 2018

Language: Английский

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Cannabis use and cannabis use disorder

Nature Reviews Disease Primers, Journal Year: 2021, Volume and Issue: 7(1)

Published: Feb. 25, 2021

Language: Английский

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Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(2), P. 611 - 681

Published: Sept. 24, 2020

This article reviews the behavioral neuroscience of extinction, phenomenon in which a behavior that has been acquired through Pavlovian or instrumental (operant) learning decreases strength when outcome reinforced it is removed. Behavioral research indicates neither nor operant extinction depends substantially on erasure original but instead new inhibitory primarily expressed context learned, as exemplified by renewal effect. Although nature inhibition may differ and either case decline responding depend both generalization decrement correction prediction error. At neural level, requires tripartite circuit involving amygdala, prefrontal cortex, hippocampus. Synaptic plasticity amygdala essential for learning, cortical neurons encoding fear memories involved retrieval. Hippocampal-prefrontal circuits mediate relapse phenomena, including renewal. Instrumental involves distinct ensembles corticostriatal, striatopallidal, striatohypothalamic well their thalamic returns (extinction) excitatory (renewal other phenomena) control over responding. The field made significant progress recent decades, although fully integrated biobehavioral understanding still awaits.

Language: Английский

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Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories – indications for novel treatments of addiction

European Journal of Neuroscience, Journal Year: 2014, Volume and Issue: 40(1), P. 2163 - 2182

Published: June 17, 2014

Abstract This review discusses the evidence for hypothesis that development of drug addiction can be understood in terms interactions between Pavlovian and instrumental learning memory mechanisms brain underlie seeking taking drugs. It is argued these behaviours initially are goal‐directed, but increasingly become elicited as stimulus–response habits by drug‐associated conditioned stimuli established conditioning. further compulsive use emerges result a loss prefrontal cortical inhibitory control over habits. Data reviewed indicate transitions from to abuse depend upon shifts ventral dorsal striatal behaviour, mediated part serial connectivity striatum midbrain dopamine systems. Only some individuals lose their use, importance behavioural impulsivity vulnerability trait predicting stimulant animals humans, together with consideration an emerging neuroendophenotype discussed. Finally, potential developing treatments considered light neuropsychological advances reviewed, including possibility targeting reconsolidation extinction reduce influences on means promoting abstinence preventing relapse.

Language: Английский

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