Inhibition and impulsivity: Behavioral and neural basis of response control

Progress in Neurobiology, Journal Year: 2013, Volume and Issue: 108, P. 44 - 79

Published: July 13, 2013

Language: Английский

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Impulsivity, Compulsivity, and Top-Down Cognitive Control

Neuron, Journal Year: 2011, Volume and Issue: 69(4), P. 680 - 694

Published: Feb. 1, 2011

Language: Английский

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Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Annual Review of Psychology, Journal Year: 2015, Volume and Issue: 67(1), P. 23 - 50

Published: Aug. 8, 2015

A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational use to compulsive drug-seeking habits, neurally underpinned by prefrontal cortical striatal control over seeking and taking well progression the ventral dorsal striatum. Here, in light of burgeoning, supportive evidence, reconsider elaborate this hypothesis, particular refinements our understanding mechanisms underlying goal-directed habitual seeking, influence drug-associated Pavlovian-conditioned stimuli on relapse, evidence for impairments top-down inhibitory behavior. We further review animal human studies have begun define etiological factors individual differences propensity become addicted drugs, leading description endophenotypes, especially cocaine addiction. consider prospect novel treatments promote abstinence relapse use.

Language: Английский

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Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry

Trends in Cognitive Sciences, Journal Year: 2011, Volume and Issue: 16(1), P. 81 - 91

Published: Dec. 12, 2011

Language: Английский

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Delayed reward discounting and addictive behavior: a meta-analysis

Psychopharmacology, Journal Year: 2011, Volume and Issue: 216(3), P. 305 - 321

Published: March 4, 2011

Language: Английский

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How “phubbing” becomes the norm: The antecedents and consequences of snubbing via smartphone

Computers in Human Behavior, Journal Year: 2016, Volume and Issue: 63, P. 9 - 18

Published: May 13, 2016

Smartphones allow people to connect with others from almost anywhere at any time. However, there is growing concern that smartphones may actually sometimes detract, rather than complement, social interactions. The term “phubbing” represents the act of snubbing someone in a setting by concentrating on one’s phone instead talking person directly. current study was designed examine some psychological antecedents and consequences phubbing behavior. We examined contributing roles Internet addiction, fear missing out, self-control, smartphone how frequency behavior being phubbed both lead perception normative. results revealed self-control predicted which turn extent phub. This path also feel normative, via (a) are themselves, (b) independently. Further, gender moderated relationship between their present findings suggest an important factor modern communication warrants further investigation.

Language: Английский

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Fractionating impulsivity: neuropsychiatric implications

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(3), P. 158 - 171

Published: Feb. 17, 2017

Language: Английский

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The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Pharmacological Reviews, Journal Year: 2016, Volume and Issue: 68(3), P. 816 - 871

Published: June 30, 2016

The nucleus accumbens is a major input structure of the basal ganglia and integrates information from cortical limbic structures to mediate goal-directed behaviors. Chronic exposure several classes drugs abuse disrupts plasticity in this region, allowing drug-associated cues engender pathologic motivation for drug seeking. A number alterations glutamatergic transmission occur within after withdrawal chronic exposure. These drug-induced neuroadaptations serve as molecular basis relapse vulnerability. In review, we focus on role that glutamate signal transduction plays addiction-related First, explore accumbens, including cell types neuronal populations present well afferent efferent connections. Next discuss rodent models addiction assess viability these testing candidate pharmacotherapies prevention relapse. Then provide review literature describing how synaptic altered also pharmacological manipulation systems can inhibit seeking laboratory setting. Finally, examine results clinical trials which designed manipulate have been effective treating human patients. Further elucidation alter will be necessary development new therapeutics treatment across all addictive substances.

Language: Английский

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Deficits in behavioural inhibition in substance abuse and addiction: A meta-analysis

Drug and Alcohol Dependence, Journal Year: 2014, Volume and Issue: 145, P. 1 - 33

Published: Aug. 24, 2014

Language: Английский

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New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

CNS Spectrums, Journal Year: 2014, Volume and Issue: 19(1), P. 69 - 89

Published: Feb. 1, 2014

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated risk-seeking harm-avoidance. However, they increasingly recognized to be linked shared neuropsychological mechanisms involving dysfunctional inhibition thoughts behaviors. In this article, we selectively review new developments in the investigation neurocognition humans, order advance our understanding pathophysiology impulsive, compulsive, addictive disorders indicate directions for research.

Language: Английский

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