Inhibition and impulsivity: Behavioral and neural basis of response control

Progress in Neurobiology, Journal Year: 2013, Volume and Issue: 108, P. 44 - 79

Published: July 13, 2013

Language: Английский

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Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

Frontiers in Genetics, Journal Year: 2014, Volume and Issue: 5

Published: April 23, 2014

The goal of this review is to discuss how behavioral tests in mice relate the pathological and neuropsychological features seen human Alzheimer's disease (AD), present a comprehensive analysis temporal progression impairments commonly used AD mouse models that contain mutations amyloid precursor protein (APP). We begin with brief overview neuropathological changes brain an outline some clinical assessments measure cognitive deficits associated disease. This followed by critical assessment tasks are model Behavioral discussed include spatial memory [Morris water maze (MWM), radial arm (RAWM), Barnes maze], associative learning (passive avoidance, fear conditioning), alternation (Y-Maze/T-Maze), recognition (Novel Object Recognition), attentional (3 5 choice serial reaction time), set-shifting tasks, reversal tasks. strengths weaknesses each these they may correlate humans. Finally, both non-cognitive 10 (PDAPP, TG2576, APP23, TgCRND8, J20, APP/PS1, TG2576 + PS1 (M146L), APP/PS1 KI, 5×FAD, 3×Tg-AD) detail. Mouse conjunction those immensely important contributing our knowledge useful tool study pathophysiology resulting deficits. However, investigators need be aware potential available preclinical terms their ability observed AD. It hope will assist selecting appropriate model, accompanying paradigms investigate different aspects pathology progression.

Language: Английский

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The neural basis of reversal learning: An updated perspective

Neuroscience, Journal Year: 2016, Volume and Issue: 345, P. 12 - 26

Published: March 12, 2016

Language: Английский

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What the orbitofrontal cortex does not do

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(5), P. 620 - 627

Published: April 28, 2015

Language: Английский

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Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience

Translational Psychiatry, Journal Year: 2018, Volume and Issue: 8(1)

Published: Jan. 30, 2018

The stagnation in drug development for schizophrenia highlights the need better translation between basic and clinical research. Understanding neurobiology of presents substantial challenges but a key feature continues to be involvement subcortical dopaminergic dysfunction those with psychotic symptoms. Our contemporary knowledge regarding dopamine has clarified where when alterations may present schizophrenia. For example, studies have shown patients show increased presynaptic function associative striatum, rather than limbic striatum as previously presumed. Furthermore, subjects deemed at high risk developing similar abnormalities striatum. Thus, our view evolve we accommodate this newly acquired information. However, research animal models been slow incorporate these findings. psychostimulant-induced locomotion, commonly utilised phenotype positive symptoms rodents, is heavily associated activation This anatomical misalignment brought into question how assess represents an opportunity improved current review focuses on role psychosis We discuss alternative phenotypes that provide more translational approach Incorporation recent findings essential if are develop meaningful models.

Language: Английский

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Dissecting impulsivity and its relationships to drug addictions

Annals of the New York Academy of Sciences, Journal Year: 2014, Volume and Issue: 1327(1), P. 1 - 26

Published: March 21, 2014

Addictions are often characterized as forms of impulsive behavior. That said, it is noted that impulsivity a multidimensional construct, spanning several psychological domains. This review describes the relationship between varieties and addiction‐related behaviors, nature causal two, underlying neurobiological mechanisms promote behaviors. We conclude available data strongly support notion both risk factor for, consequence of, drug alcohol consumption. While evidence indicating subtypes behavior uniquely informative—either biologically or with respect to their relationships addictions—is convincing, multiple lines study link distinct low dopamine D2 receptor function perturbed serotonergic transmission, revealing shared subtypes. Therefore, common biological framework involving monoaminergic transmitters in key frontostriatal circuits may self‐administration Further dissection these needed before next phase genetic genomic discovery will be able reveal sources vulnerability for addiction indexed by impulsivity.

Language: Английский

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Compulsivity in obsessive–compulsive disorder and addictions

European Neuropsychopharmacology, Journal Year: 2015, Volume and Issue: 26(5), P. 856 - 868

Published: Dec. 17, 2015

Language: Английский

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Development of the uncinate fasciculus: Implications for theory and developmental disorders

Developmental Cognitive Neuroscience, Journal Year: 2015, Volume and Issue: 14, P. 50 - 61

Published: June 23, 2015

The uncinate fasciculus (UF) is a long-range white matter tract that connects limbic regions in the temporal lobe to frontal lobe. UF one of latest developing tracts, and continues maturing into third decade life. As such, individual differences maturational profile may serve explain behavior. Indeed, atypical macrostructure microstructure have been reported numerous studies individuals with developmental psychiatric disorders such as social deprivation maltreatment, autism spectrum disorders, conduct disorder, risk taking, substance abuse. present review evaluates what we currently know about UF's trajectory reviews literature relating abnormalities specific disorders. Additionally, take dimensional approach critically examine symptoms behavioral impairments demonstrated cluster aberrations, an effort relate these our speculations regarding functionality UF. We suggest core problems memory retrieval, reward valuation computation, impulsive decision making be linked aberrations microstructure.

Language: Английский

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Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum

World Psychiatry, Journal Year: 2021, Volume and Issue: 20(2), P. 171 - 193

Published: May 18, 2021

The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address limitations traditional mental disorder diagnoses. These include arbitrary boundaries between and normality, co‐occurrence in the modal case, heterogeneity presentation within dis­orders, instability diagnosis patients. This paper reviews evidence on validity utility disinhibited externalizing antagonistic spectra HiTOP, which together constitute a broad superspectrum. are composed elements subsumed variety disorders described recent DSM nosologies, including most notably substance use “Cluster B” personality disorders. superspectrum ranges from normative levels impulse control self‐assertion, maladaptive disinhibition antagonism, extensive polysubstance involvement psychopathology. A rich literature supports superspectrum, spectra. encompasses common genetic influences, environmental risk factors, childhood antecedents, cognitive abnormalities, neural alterations, treatment response. structure these validators mirrors phenotypic with some correlates more specific or spectra, others relevant entire underlining hierarchical domain. Compared diagnostic categories, conceptualization shows improved utility, reliability, explanatory capacity, clinical applicability. one aspect general approach psychopathology offered by HiTOP can make classification useful both research clinic.

Language: Английский

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Cognitive deficits in single App knock-in mouse models

Neurobiology of Learning and Memory, Journal Year: 2016, Volume and Issue: 135, P. 73 - 82

Published: July 2, 2016

Transgenic mouse models of Alzheimer’s disease (AD) with nonphysiologic overexpression amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in different combinations were recently developed. The validity these AD from a behavioral viewpoint, however, has not been extensively evaluated. Thus, using an automated behavior monitoring system, we analyzed domains, including executive function, learning memory. App-KI NL-G-F showed clear deficits spatial memory flexible learning, enhanced compulsive behavior, reduced attention performance. Mice NL-F exhibited modest abnormalities. had greater more rapid accumulation Aβ deposits glial responses. These findings reveal that pathologic is sufficient to produce broad cognitive domains lines levels pathophysiology are useful AD.

Language: Английский

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