Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations

Genes, Journal Year: 2023, Volume and Issue: 14(7), P. 1506 - 1506

Published: July 24, 2023

Nutrition and metabolism modify epigenetic signatures like histone acetylation DNA methylation. Histone methylation in the central nervous system (CNS) can be altered by bioactive nutrients gut microbiome via gut-brain axis, which turn modulate neuronal activity behavior. Notably, microbiome, with more than 1000 bacterial species, collectively contains almost three million functional genes whose products interact millions of human marks 30,000 a dynamic manner. However, genetic makeup shapes composition, food/nutrient metabolism, landscape, as well. Here, we first discuss effect changes microbial structure composition shaping specific alterations brain their role onset progression major mental disorders. Afterward, potential interactions among maternal diet/environmental factors, nutrition, gastrointestinal roles accelerating or delaying severe illnesses will discussed. We also provide an overview association between oxidative stress, inflammation through mechanisms. Finally, present some underlying mechanisms involved mediating influence probiotics on health modifications.

Language: Английский

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Antibiotic-induced gut dysbiosis and cognitive, emotional, and behavioral changes in rodents: a systematic review and meta-analysis

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Sept. 1, 2023

There are previous epidemiological studies reporting associations between antibiotic use and psychiatric symptoms. Antibiotic-induced gut dysbiosis alteration of microbiota-gut-brain axis communication has been proposed to play a role in this association. In systematic review meta-analysis, we reviewed published articles that have presented results on changes cognition, emotion, behavior rodents (rats mice) after antibiotic-induced dysbiosis. We searched three databases—PubMed, Web Science, SCOPUS identify such using dedicated search strings extracted data from 48 articles. Increase anxiety depression-like was reported 32.7 40.7 percent the study-populations, respectively. Decrease sociability, social novelty preference, recognition memory spatial cognition found 18.1, 35.3, 26.1, 62.5 Only one bacterial taxon (increase Proteobacteria ) showed statistically significant association with behavioral anxiety). were no consistent findings statistical significance for potential biomarkers [Brain-derived neurotrophic factor (BDNF) expression hippocampus, serum corticosterone circulating IL-6 IL-1β levels]. Results meta-analysis revealed symptoms negative valence system (including depression) cognitive (decreased cognition) intake ( p < 0.05). However, between-study heterogeneity publication bias Risk evaluated be high majority studies. identified discussed several reasons could contribute examined. The provide promising evidence there is indeed an psychopathologies. inconsistencies implemented methodologies make generalizing these difficult. Gut microbiota depletion antibiotics may useful strategy evaluate if how microbes influence behavior, but used precludes any definitive interpretations translational impact clinical practice.

Language: Английский

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Effect of germ-free status on transcriptional profiles in the nucleus accumbens and transcriptomic response to chronic morphine

Molecular and Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 126, P. 103874 - 103874

Published: June 13, 2023

Language: Английский

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Substance-Induced Psychiatric Disorders, Epigenetic and Microbiome Alterations, and Potential for Therapeutic Interventions

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(8), P. 769 - 769

Published: July 30, 2024

Substance use disorders (SUDs) are complex biopsychosocial diseases that cause neurocognitive deficits and neurological impairments by altering the gene expression in reward-related brain areas. Repeated drug gives rise to alterations DNA methylation, histone modifications, of microRNAs several areas may be associated with development psychotic symptoms. The first section this review discusses how substance contributes symptoms via epigenetic alterations. Then, we present more evidence about link between SUDs next presents associations paternal maternal exposure substances brains offspring role diet preventing substance-induced impairments. introduce potential therapeutic agents/approaches such as methyl-rich diets modify for alleviating or depression SUDs. Next, discuss use–gut microbiome interactions contribute through gut microbiome-derived metabolites become new therapeutics normalizing aberrations. Finally, address possible challenges future perspectives patients modulating diets, epigenome, microbiome.

Language: Английский

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Gut microbiome depletion modulates cocaine-induced behavioral and transcriptional responses in female mice

Journal of Neuroimmunology, Journal Year: 2025, Volume and Issue: unknown, P. 578609 - 578609

Published: April 1, 2025

Language: Английский

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Ji-Ming-San Enhances Intestinal Circadian Rhythms and Mitigates Colitis in Mice: The Role of Epithelial RORα

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156759 - 156759

Published: April 1, 2025

Language: Английский

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The gut microbiota contributes to methamphetamine-induced reproductive toxicity in male mice

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116457 - 116457

Published: May 15, 2024

Methamphetamine (METH) is a psychostimulant drug belonging to the amphetamine-type stimulant class, known exert male reproductive toxicity. Recent studies suggest that METH can disrupt gut microbiota. Furthermore, gut-testis axis concept has gained attention due potential link between microbiome dysfunction and health. Nonetheless, role of microbiota in mediating impact on toxicity remains unclear. In this study, we employed mouse model exposed escalating doses assess sperm quality, testicular pathology, hormone levels. The fecal transplantation method was investigate effect Transcriptomic, metabolomic, microbiological analyses were conducted explore damage mechanism system caused by METH. We found exposure led hormonal disorders, decreased changes metabolome mice. Testicular RNA sequencing revealed enrichment several Gene Ontology terms associated with processes, as well PI3K-Akt signaling pathways. FMT conveyed similar from METH-treated mice healthy recipient aforementioned findings plays substantial facilitating METH, thereby highlighting prospective avenue for therapeutic intervention context METH-induced infertility.

Language: Английский

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Short-chain fatty acids mitigate Methamphetamine-induced hepatic injuries in a Sigma-1 receptor-dependent manner

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 280, P. 116538 - 116538

Published: June 3, 2024

Methamphetamine (Meth) is a potent psychostimulant with well-established hepatotoxicity. Gut microbiota-derived short-chain fatty acids (SCFAs) have been reported to yield beneficial effects on the liver. In this study, we aim further reveal mechanisms of Meth-induced hepatic injuries and investigate potential protective SCFAs. Herein, mice were intraperitoneally injected 15 mg/kg Meth induce injuries. The composition fecal microbiota SCFAs was profiled using 16 S rRNA sequencing Gas Chromatography/Mass Spectrometry (GC/MS) analysis, respectively. Subsequently, supplementation performed evaluate against Additionally, Sigma-1 receptor knockout (S1R-/-) fluvoxamine (Flu), an agonist S1R, introduced underlying Our results showed that activated S1R induced autophagy, inflammation, oxidative stress by stimulating MAPK/ERK pathway. Meanwhile, disrupted product-related microbiota, leading reduction in (especially Acetic acid Propanoic acid). Accompanied optimization gut normalized expression ameliorated repressing Effectively, repressed activation pathway Finally, overexpression stimulated yielded comparable adverse phenotypes administration. These findings suggest relied which could be alleviated supplementation. study confirms crucial role for first time provides preemptive therapy.

Language: Английский

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Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Metabolites, Journal Year: 2023, Volume and Issue: 13(3), P. 361 - 361

Published: Feb. 28, 2023

This study aimed to investigate the changes in intestinal homeostasis and metabolism mice after methamphetamine (MA) administration exercise intervention. In this study, male C57BL/B6J were selected establish a model of methamphetamine-induced addiction, gut microbiota composition, short-chain fatty acids (SCFAs), amino acid levels assessed by 16S rRNA, liquid chromatography-tandem mass spectrometry, gas respectively. The results showed that 23 dominant microbiota, 12 acids, 1 SCFA remarkably higher 9 6 SCFAs lower group than control group. Among top 10 markers with opposite trends between intervention group, differential microbiomes included Oscillibacter, Alloprevotella, Colidextribacter, Faecalibaculum, Uncultured, Muribaculaceae, Negativibacillus; proline; isovaleric pentanoic acid. Proline was negatively correlated Negativibacillus positively suggested moderate-intensity aerobic may modulate composition induced MA administration.

Language: Английский

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Differences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 23, 2023

Background The transition from methamphetamine (MA) casual use (MCU) to compulsive is enigmatic as some MA users can remain in use, but cannot. There a knowledge gap if gut microbiota (GM) play role differing MCU disorder (MUD). We aimed investigate the clinical features and GM differences between individuals with MUD. Method recruited two groups of –MCU MUD – matched them according age body mass index (n=21 each group). Participants were accessed using Semi-Structured Assessment for Drug Dependence Alcoholism, their fecal samples undergone 16S ribosomal DNA sequencing. compared hosts’ diversity, composition, structure (represented by enterotypes) groups. have identified differential microbes performed network analyses connecting traits. Result Compared users, had higher incidences MA-induced neuropsychiatric symptoms (e.g., paranoia, depression) withdrawal fatigue, drowsiness, increased appetite), well stronger cravings intentions MA, tolerance. diversity showed no significant groups, four genera (Halomonas, Clostridium, Devosia, Dorea) enriched (p<0.05). Three distinct enterotypes all Ruminococcus-driven enterotype 2 was dominant (61.90% vs. 28.60%, p=0.03). Network analysis shows that Devosia hub genus (hub = 0.75), which not only related counts diagnostic criteria (ρ=0.40; p=0.01) also such reduced social activities (ρ=0.54; p<0.01). associated intention (ρ=0.48; p<0.01), tolerance (ρ=0.38; p=0.01), craving (ρ=0.37; Conclusion Our findings suggest might be influential factors differentiate MUD, further studies are warranted.

Language: Английский

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