Gut microbiota-related neuroinflammation at the crossroad of food reward alterations: implications for eating disorders

Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 333397

Published: Feb. 17, 2025

The link between gut microbiome and eating behaviours, especially palatable food intake, is a growing focus of scientific investigation. complex ecosystem microorganisms in the influences host metabolism, immune function neurobehavioural signalling. This review explores role neuroinflammation dysregulations food-induced reward signalling potential causal microbiota on these proinflammatory processes. Particular attention given to disorders (ED, specifically anorexia nervosa, binge disorder bulimia nervosa) links with microbiota, alterations neuroinflammation. Finally, we propose modulation as promising therapeutic strategy ED.

Language: Английский

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A gut (microbiome) feeling about addiction: Interactions with stress and social systems

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 30, P. 100629 - 100629

Published: March 18, 2024

In recent years, an increasing attention has given to the intricate and diverse connection of microorganisms residing in our gut their impact on brain health central nervous system disease. There been a shift mindset understand that drug addiction is not merely condition affects brain, it now being recognized as disorder also involves external factors such intestinal microbiota, which could influence vulnerability development addictive behaviors. Furthermore, stress social interactions, are closely linked powerful modulators addiction. This review delves into mechanisms through microbiota-stress-immune axis may shape work integrates preclinical clinical evidence demonstrate bidirectional communication between stress, behaviors, substance use disorders suggesting microbes might modulate having significance

Language: Английский

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Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 114, P. 311 - 324

Published: Aug. 30, 2023

Language: Английский

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Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 49(2), P. 386 - 395

Published: Aug. 2, 2023

Language: Английский

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Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids

eNeuro, Journal Year: 2023, Volume and Issue: 11(2), P. ENEURO.0388 - 23.2023

Published: Dec. 21, 2023

Opioid use disorder (OUD) is a public health crisis currently being exacerbated by increased rates of and overdose synthetic opioids, primarily fentanyl. Therefore, the identification novel biomarkers treatment strategies to reduce problematic fentanyl relapse taking critical. In recent years, there has been growing body work demonstrating that gut microbiome can serve as potent modulator behavioral transcriptional responses both stimulants opioids. Here, we advance this define how manipulations drive intake fentanyl-seeking in translationally relevant drug self-administration model. Depletion male rats with broad spectrum antibiotics leads administration on fixed ratio, progressive seeking after abstinence. Utilizing 16S sequencing contents from these animals, specific populations bacteria correlate closely levels taking. Additionally, global proteomic analysis nucleus accumbens following manipulation status alters functional landscape key limbic substructure. These data demonstrate an altered marked changes synaptic proteome response repeated treatment. Finally, effects depletion are reversible upplementation derived short-chain fatty acid metabolites. Taken together, findings establish clear relevance for gut-brain signaling models OUD lay foundations further translational space.

Language: Английский

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Brief disruption of the microbiome has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract Adolescence is a critical period for the initiation of problematic drug use, which significantly increases risk developing substance use disorders later in life. This heightened vulnerability partly attributed to immaturity prefrontal cortex, brain region both essential decision-making and implicated reward. During adolescence, peripheral systems, such as gut microbiome, also undergo substantial changes. Emerging evidence suggests that disruptions microbiome can influence gene expression reward behaviors rodent models. In this study, we investigated effects disruption on morphine cortical adolescent adult mice. Using oral antibiotics transiently disrupt found short-term antibiotic exposure reduced place preference specifically separate cohort, observed treatment altered transcriptomic response medial cortex across all age groups. Notably, changes induced by were age-specific, with distinct patterns adolescents compared adults. These findings establish foundation future research into role opioid highlight potential pathways underlying age-dependent differences sensitivity.

Language: Английский

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Synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 25, 2025

Abstract Alcohol use disorder is marked by disrupted behavioral and emotional states which persist into abstinence. The enduring synaptic alterations that remain despite the absence of alcohol are interest for interventions to prevent relapse. Here, 28 male rhesus macaques underwent over 20 months drinking interspersed with three 30-day forced abstinence periods. After last period, we paired direct sub-second dopamine monitoring via ex vivo voltammetry in nucleus accumbens core RNA-sequencing ventral tegmental area. We found persistent augmentation transporter function, kappa opioid receptor sensitivity, putative dynorphin release – all inhibitory regulators act decrease extracellular dopamine. Surprisingly, though transcript expression was not altered, relationship between gene functional readouts these encoded proteins highly dynamic altered history. These results outline long-lasting impact suggest assessment transcript-function relationships critical rational design precision therapeutics.

Language: Английский

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Clinical and Preclinical Evidence for Gut Microbiome Mechanisms in Substance Use Disorders

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(4), P. 329 - 338

Published: Aug. 10, 2023

Language: Английский

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From microbes to mind: germ-free models in neuropsychiatric research

mBio, Journal Year: 2024, Volume and Issue: 15(10)

Published: Aug. 29, 2024

The gut-microbiota-brain axis refers to the bidirectional communication system between gut, its microbial community, and brain. This interaction involves a complex interplay of neural pathways, chemical transmitters, immunological mechanisms. Germ-free animal models have been extensively employed investigate interactions, significantly contributing our current understanding role intestinal microbes in brain function. However, despite many benefits, this absence microbiota is not futile. animals present physiological neurodevelopmental alterations that can persist even after reconstitution with normal microbiota. Therefore, main goal minireview discuss how some inherent limitations model interfere conclusion obtained when using these study nature neuropsychiatric disorders. Furthermore, we examine inclusion use antibiotic-based treatments as an alternative research gut-brain interactions.

Language: Английский

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Distinct Dendritic Morphological Changes in the Nucleus Accumbens of Microbiota-deficient Male Mice

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Abstract The gut microbiota has been shown to be an important regulator of brain and behaviour. Germ-free rodents are a key model study the microbiome-gut-brain axis reveal microbial underpinnings diseases, including those related psychiatric illnesses. present evaluated whether absence could alter morphological development nucleus accumbens, region located in ventral striatum involved stress, mood addiction. In germ-free mice, there was dendritic hypertrophy medium spiny neurons shell elongation core. This led increase number stubby spines within both thin Taken together, these results indicate that is essential for normal structure accumbens altered remodelling may contribute maladaptive disorders.

Language: Английский

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