SAUSI: a novel assay for measuring social anxiety and motivation DOI Creative Commons
Jordan Grammer,

Rene Valles,

Alexis Bowles

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

ABSTRACT Social aversion is a key feature of numerous mental health disorders such as Anxiety and Autism Spectrum Disorders. Nevertheless, the biobehavioral mechanisms underlying social remain poorly understood. Progress in understanding etiology has been hindered by lack comprehensive tools to assess model systems. Here, we created new behavioral task – Selective Access Unrestricted Interaction (SAUSI), which integrates elements motivation, hesitancy, decision-making, free interaction enable wholistic assessment mice. Using this novel assay, found that isolation-induced mice largely driven increases fear motivation. Deep learning analyses revealed unique footprint socially aversive state produced isolation, demonstrating compatibility modern computational approaches with SAUSI. was further assessed using traditional assays including 3-chamber sociability assay resident intruder were sufficient reveal fragments phenotype, changes either motivation or interaction, but failed provide aversion. Critically, these not components aversion, freezing hesitancy behaviors. Lastly, demonstrated SAUSI generalizable, it can be used induced non-social stressors, foot shock. Our findings debut for toolbox one overcomes limitations previous assays, allowing both choice well offers approach assessing rodents.

Language: Английский

Cross‐species translational paradigms for assessing positive valence system as defined by the RDoC matrix DOI Open Access

Tyler D. Dexter,

Benjamin Z. Roberts, Samantha M. Ayoub

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 169(1)

Published: Oct. 28, 2024

Abstract Functions associated with processing reward‐related information are fundamental drivers of motivation, learning, and goal‐directed behavior. Such functions have been classified as the positive valence system under Research Domain Criteria (RDoC) criteria negatively impacted across a range psychiatric disorders mental illnesses. The is composed three comprehensive categories containing related but dissociable that organized into either Reward Responsiveness, Learning, or Valuation. presence overlapping behavioral dysfunction diagnostic in‐part what motivated RDoC initiative, which emphasized study illness focus on investigating relevant behavior cognitive their underlying mechanisms, rather than separating efforts (i.e., transdiagnostic). Moreover, approach well‐suited for preclinical neuroscience research, rise in genetic toolboxes neurotechnologies enables researchers to probe specific cellular targets high specificity. Thus, there an opportunity dissect whether behaviors supported by shared distinct neural mechanisms. For research effectively inform our understandings human however, paradigms should predictive, neurobiological, pharmacological predictive validity test. Touchscreen‐based testing systems provide further advantage this endeavor enabling tasks be presented animals using same media task design humans. Here, we outline primary review work has done cross‐species investigate neurobiology neurochemistry functioning. Additionally, clinical outlined RDoC, along and/or need validation analogous rodent implementing touchscreen‐based systems. image

Language: Английский

Citations

4
Editorial: Spanning the spectrum of social behavior: towards more translationally relevant animal models DOI
Daniele Caprioli, Sam A. Golden, Christelle Baunez

et al.

Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

0
Neural mechanisms underlying strain preference behaviour and plasticity in mice DOI Creative Commons

Kaizhen Peng,

Lili Tan,

Shiyu You

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

All social animals, including humans, have different identities that generate unique interactions. Social preference behaviours, integration, prosocial behaviour, and cooperation, a wide impact on an individual's life. However, the neural mechanisms underlying preferences are not yet clear. In this study, using mice as model we investigated strain preference, which is based identification. We revealed, for first time, behaviour of heterogeneous; is, C57 prefer to interact with same strain, whereas KM strain. further confirmed in can be plastically altered by changing nurturing environment increasing exposure other strains. Finally, screened brain regions related mouse revealed activity periaqueductal grey (PAG) was only consistent both but also coordinated alteration preference. subsequently used muscarine inhibit PAG C57BL/6J found strain-specific disappeared. These results showed key region regulating its plasticity. This work fills gap study research.

Language: Английский

Citations

0
The 3D Vertical Maze: A new model system for studying the interactions between social and spatial cognition DOI Creative Commons
Taylor B. Wise, Victoria L. Templer, Rebecca D. Burwell

et al.

Journal of Neuroscience Methods, Journal Year: 2025, Volume and Issue: unknown, P. 110414 - 110414

Published: Feb. 1, 2025

Language: Английский

Citations

0
A rat model of volitional mutual social interactions DOI
Cody A. Lis, Antonino Casile,

Bronte Feulner

et al.

Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Sex differences in the social motivation of rats: Insights from social operant conditioning, behavioural economics, and video tracking DOI Creative Commons
Joel S. Raymond, Simone Rehn, Morgan H. James

et al.

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 19, 2024

Social behaviour plays a key role in mental health and wellbeing, developing greater understanding of mechanisms underlying social interaction-particularly motivation-holds substantial transdiagnostic impact. Common rodent behavioural assays used to assess are limited their assessment motivation, whereas the operant conditioning model can provide unique valuable insights into motivation. Further characterisation common experimental parameters that may influence motivation within model, as well complementary methodological analytical approaches, warranted. This study investigated effects biological sex, housing condition, time-of-day, on using model. involved training rats lever press (FR1) for 60-s access reward (same-sex conspecific stimulus). Subjects were male female Wistar rats, housed under individual or paired conditions, sessions conducted either mid-late light phase (ZT6-10) early-mid dark (ZT13-17). A economics approach was implemented measure demand stimulus partner sex (same- vs. opposite-sex stimulus) responding. Additionally, video tracking analyses degree convergence between appetitive consummatory behaviours. Biological interaction housing, potently influenced time-of-day did not. Behavioural demonstrated both hedonic set-point elasticity demand. Video analysis during revealed behaviours not necessarily convergent, indicate potential satiety. Lastly, oestrus impact isolation-dependent differences exist assessed by conditioning. The represents an optimal preclinical assay comprehensively evaluates offers platform future investigations neurobiological These findings highlight importance continued consideration inclusion variable studies. Humans creatures-our everyday interactions with others support this provides play our wellbeing. For those experiencing people's engage wane, which lead them withdraw from who them. Therefore, develop better treatment strategies these we need gain deeper Studying animals facilitate investigation it allows causal neurobiology is possible human experiments. An way where learn opens door interact another rat short time. characterised testing whether rats' seek rat. We found more socially motivated than males, living alone rat; interestingly, effect affected females males. Regardless opposite sex. new will help guide research other conditions.

Language: Английский

Citations

2
A novel behavioral apparatus for spontaneous exploration and operant conditioning of social information under spatial conditions in rats DOI
Taylor B. Wise, Victoria L. Templer, Rebecca D. Burwell

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

ABSTRACT Background Evidence from the fields of evolutionary biology and neuroscience supports theory that spatial cognition social share neural mechanisms. Rodent models are widely used to study either or cognition, but few studies have explored interactions between cognitive domains due lack appropriate paradigms. New method Our introduces Vertical Maze (VM), a novel behavioral apparatus designed measure multiple aspects cognition. The VM features standard 3-chamber maze positioned above multilevel columns allowing for presentation conspecifics at varying distances familiarity levels. This arrangement enables serve as discriminative stimuli both spontaneous goal-oriented assessments. three-dimensional design allows rats use multisensory cues judge distance, direction, identity conspecifics. Results In present study, we found can 1) discriminate distance located below them in an operant conditioning task, 2) novelty when presented near, middle, far exploration task. Critically, it was necessary explore all levels perform these discriminations. Comparison with existing methods new advances field by permitting information (conspecifics) different distances. discriminations more direct comparison measures across domains. Importantly, level engages auditory, visual, olfactory systems, encouraging robust representation distance. Conclusions results confirm is effective tool studying facilitating development automated tasks areas. opens avenues investigating foundations behavior, well exploring possibility shared mechanisms

Language: Английский

Citations

2
SAUSI: a novel assay for measuring social anxiety and motivation DOI Creative Commons
Jordan Grammer,

Rene Valles,

Alexis Bowles

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

ABSTRACT Social aversion is a key feature of numerous mental health disorders such as Anxiety and Autism Spectrum Disorders. Nevertheless, the biobehavioral mechanisms underlying social remain poorly understood. Progress in understanding etiology has been hindered by lack comprehensive tools to assess model systems. Here, we created new behavioral task – Selective Access Unrestricted Interaction (SAUSI), which integrates elements motivation, hesitancy, decision-making, free interaction enable wholistic assessment mice. Using this novel assay, found that isolation-induced mice largely driven increases fear motivation. Deep learning analyses revealed unique footprint socially aversive state produced isolation, demonstrating compatibility modern computational approaches with SAUSI. was further assessed using traditional assays including 3-chamber sociability assay resident intruder were sufficient reveal fragments phenotype, changes either motivation or interaction, but failed provide aversion. Critically, these not components aversion, freezing hesitancy behaviors. Lastly, demonstrated SAUSI generalizable, it can be used induced non-social stressors, foot shock. Our findings debut for toolbox one overcomes limitations previous assays, allowing both choice well offers approach assessing rodents.

Language: Английский

Citations

1