Regulated and Emerging Mycotoxins occurrence in plant-based beverages from the Italian market DOI Creative Commons
Raquel Torrijos, Octavian Augustin Mihalache, Chiara Dall’Asta

et al.

Food Control, Journal Year: 2024, Volume and Issue: unknown, P. 111051 - 111051

Published: Nov. 1, 2024

Language: Английский

Simultaneous detection of mycotoxins and pesticides in human urine samples: A 24-h diet intervention study comparing conventional and organic diets in Spain DOI Creative Commons
José Gallardo, Jesús Marín‐Sáez, Vicente Sanchís

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 188, P. 114650 - 114650

Published: April 9, 2024

Language: Английский

Citations

7
Human Biomonitoring Guidance Values for Deoxynivalenol Derived under the European Human Biomonitoring Initiative (HBM4EU) DOI Creative Commons
Marcel Mengelers, A. Brand, Shensheng Zhao

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(3), P. 139 - 139

Published: March 7, 2024

The mycotoxin deoxynivalenol (DON) was one of the priority substances in European Joint Human Biomonitoring Initiative (HBM4EU) project. In this study, to better interpret actual internal exposure DON general population and safeguard public health, human biomonitoring guidance values for (HBM-GVGenPop) were derived. HBM-GVGenPop based on either total (DON its glucuronides) or DON’s main metabolite (DON-15-GlcA) levels 24-h urine samples, resulting a 0.023 µg/mL 0.020 DON-15-GlcA. use samples is recommended fact that metabolites have short elimination half-life (T1/2), 95% cumulative amount excreted within 12 h after intake. T1/2 DON, DON-15-GlcA, estimated be 2.55 h, 2.95 respectively. Therefore, sample reflects almost all from previous day, type considered derivation DON.

Language: Английский

Citations

6
Assessing human toxicity and ecotoxicity impacts of agricultural pesticide use in Iran based on the USEtox model DOI Creative Commons

Mohammad Paeezi,

Reza Saeedi, Amin Bagheri

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117785 - 117785

Published: Jan. 30, 2025

Language: Английский

Citations

0
Assessing the differential responses in normal and inflamed in vitro intestinal models exposed to food contaminants complex mixtures DOI Creative Commons
Helena Ramos, Mafalda Ribeiro, Ana Margarida Araújo

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 205, P. 115907 - 115907

Published: Feb. 11, 2025

Language: Английский

Citations

0
Occurrence of Cyclotriphosphazene Derivatives in Human Urine: Assessment of Human Exposure DOI
Kaiyuan Huang, Yuxiang Weng,

Zebin Fang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multi-Mycotoxin Determination in Human Urine by Uhplc-Ms/Ms: An Environmentally Friendly and High-Throughput Approach DOI
Borja Peris-Camarasa, Olga Pardo, Pablo Dualde

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Analytical challenges and opportunities in the study of endocrine disrupting chemicals within an exposomics framework DOI Creative Commons
Jesús Marín‐Sáez, Maykel Hernández‐Mesa, Germán Cano-Sancho

et al.

Talanta, Journal Year: 2024, Volume and Issue: 279, P. 126616 - 126616

Published: July 24, 2024

Exposomics aims to measure human exposures throughout the lifespan and changes they produce in body. Exposome-scale studies have significant potential understand interplay of environmental factors with complex multifactorial diseases widespread our society whose origin remain unclear. In this framework, study chemical exposome cover all their effects health but, today, goal still seems unfeasible or at least very challenging, which makes for now only a concept. Furthermore, faces several methodological challenges such as moving from specific targeted methodologies towards high-throughput multitargeted non-targeted approaches, guaranteeing availability quality biological samples obtain analytical data, standardization applied methodologies, well statistical assignment increasingly datasets, identification (un)known analytes. This review discusses various steps involved applying concept an perspective. It provides overview wide variety existing methods instruments, highlighting complementarity develop combined strategies advance characterization. addition, focuses on endocrine disrupting chemicals (EDCs) show how studying even minor part represents great challenge. Analytical exposomics context shown elucidate role EDCs outcomes. However, translating innovative into etiological research risk assessment will require multidisciplinary effort. Unlike other articles focused exposomics, offers holistic view perspective chemistry discuss entire workflow finally valuable results.

Language: Английский

Citations

2
Assessment of Mycotoxin Exposure and Associated Risk in Pregnant Dutch Women: The Human Biomonitoring Approach DOI Creative Commons

Hannah P. McKeon,

Marloes A. A. Schepens,

A. Brand

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(6), P. 278 - 278

Published: June 18, 2024

Mycotoxins are toxic secondary metabolites produced by various fungi that can contaminate food crops, which, in turn, may lead to human exposure. Chronic exposure mycotoxins cause adverse health effects including reproductive and developmental toxicity. Pregnant women their foetuses present a vulnerable group for cross the placenta. Human biomonitoring of provides real-life approach estimate internal In this pilot study, 24-h urine samples from 36 pregnant Dutch were analysed aflatoxin M1 (AFM1), total deoxynivalenol (DON), de-epoxy-deoxynivalenol (DOM-1), zearalenone (ZEN), α-zearalenol (α-ZEL), β-zearalenol (β-ZEL) zearalanone (ZAN), where ‘total’ refers conjugated forms. Serum these fumonisin B1 (FB1) ochratoxin A (OTA). All measured using liquid chromatography–tandem mass spectrometry (LC-MS/MS). The most prevalent DON, ZEN OTA, with detection frequency 100%. DOM-1, α-ZEL β-ZEL detected but lesser extent, while AFM1, ZAN FB1 undetected. Median concentrations 4.75 μg DON/L, 0.0350 DOM-1/L, 0.0413 ZEN/L, 0.0379 α-ZEL/L, 0.0189 β-ZEL/L, 0.121 OTA/L. calculated median concentration its was 0.105 μg/L. Based on two separate risk assessment approaches, DON considered be low concern. Similarly, For non-neoplastic concern based group, neoplastic majority participants group. findings study confirm presence serum women, ZEN, OTA frequently detected. Exposure all except which participants. study’s offer valuable insights should confirmed larger more diverse sample general population.

Language: Английский

Citations

1
Identification of Beauvericin metabolites using rat and human liver microsomes and in vivo urinary excretion study in rats for biomonitoring application DOI

Anushka Pandey,

C. Yahavi,

Manisha Bhateria

et al.

Toxicology in Vitro, Journal Year: 2024, Volume and Issue: unknown, P. 105969 - 105969

Published: Nov. 1, 2024

Language: Английский

Citations

1
Liquid chromatography-tandem mass spectrometry for the determination of multiple mycotoxins in serum through suspect screening and targeted approaches: Advancing human mycotoxin biomonitoring DOI
María del Mar Delgado‐Povedano, E. Maris,

Nina Kellner

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112562 - 112562

Published: Dec. 1, 2024

Language: Английский

Citations

1