Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis DOI Open Access

Saixin Li,

Zeyu Zhang, Zheng Wang

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 27(6)

Published: April 12, 2024

Hepatocellular carcinoma (HCC) is a malignancy associated with high morbidity and mortality rates. Conversion therapy provides patients unresectable HCC (uHCC) the opportunity to undergo radical treatment achieve long‑term survival. Despite accumulating evidence regarding efficacy of conversion therapy, optimal approach for such remains uncertain. Lenvatinib (LEN) has shown tolerable rates adverse events (AEs) when applied in combination immune checkpoint inhibitors (ICIs) or locoregional (LRT) over past decade. Therefore, present meta‑analysis was performed systematically assess safety LEN‑based regimens therapies uHCC. Data on outcomes, including rate, objective response rate (ORR), disease control (DCR) AE incidence uHCC, were collected. A systematic literature search using MEDLINE, Embase, Web Science Cochrane Library databases, up date September 1, 2023. In total, 16 studies, encompassing total 1,650 cases included final meta‑analysis. The pooled LEN alone, + ICI, LRT ICI calculated be 0.04 (95% CI, 0.00‑0.07; I²=77%), 0.23 0.16‑0.30; I²=66%), 0.14 0.10‑0.18; I²=0%) 0.35 0.23‑0.47; I²=88%), respectively. ORRs found 0.45 0.23‑0.67; I²=96%), 0.49 0.39‑0.60; I²=78%), 0.43 0.24‑0.62; I²=88%) 0.69 0.56‑0.82; I²=92%), DCRs observed 0.77 0.73‑0.81; I²=23%), 0.82 0.69‑0.95; I²=90%), 0.67 0.39‑0.94; I²=94%) 0.87 0.82‑0.93; I²=67%), grade ≥3 AEs 0.25 0.14‑0.36; I²=89%), 0.34‑0.53; 0.42 0.19‑0.66; I²=81%) 0.17‑0.54; I²=94%), These findings suggested that strategies may confer acceptable tolerability particular, without LRT, appears represent highly effective regimen, an well‑characterized profile.

Language: Английский

The impact of ECOG performance status on efficacy of immunotherapy and immune-based combinations in cancer patients: the MOUSEION-06 study DOI
Veronica Mollica, Alessandro Rizzo, Andrea Marchetti

et al.

Clinical and Experimental Medicine, Journal Year: 2023, Volume and Issue: 23(8), P. 5039 - 5049

Published: Aug. 3, 2023

Language: Английский

Citations

126
Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer DOI
Zhen Huang, Fanying Meng,

Lin-Zhu Lu

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(29), P. 3511 - 3533

Published: July 28, 2024

(CB), used in traditional Chinese medicine, exhibits anti-tumor effects various cancer models. It also constitutes an integral component of a compound formulation known as Pien Tze Huang, which is indicated for the treatment liver cancer. However, its impact on tumor microenvironment, particularly tumor-associated macrophages (TAMs), not well understood.

Language: Английский

Citations

23
0,1,2,3D nanostructures, types of bulk nanostructured materials, and drug nanocrystals: An overview DOI Creative Commons

Ali Assim Adul-Rasool,

Duaa Mohammed Athair,

Haider Kamil Zaidan

et al.

Cancer Treatment and Research Communications, Journal Year: 2024, Volume and Issue: 40, P. 100834 - 100834

Published: Jan. 1, 2024

Functional materials are required to meet the needs of society, such as environmental protection, energy storage and conversion, integrated product production, biological medical processing. bulk nanostructured a research concept that combines nanotechnology with other fields supramolecular chemistry, science, life science develop logically functional from nanodevices. In this review article, nanostructures synthetized by different methods based on types nature nanomaterials. broad sense "top-down" "bottom-up" two foremost synthesize top-down method have been reduced nanomaterials, in case bottom-up method, nanomaterials synthesized elementary level. The which being used chemical vapor deposition thermal decomposition, hydrothermal synthesis, solvothermal pulsed laser ablation, templating combustion microwave gas phase conventional Sol-Gel method. We also briefly discuss various physical for producing then applications many areas storage, supercapacitors, sensors, wastewater treatment, drug delivery nanocrystals. Finally, future challenges nanoarchitecture concepts further development discussed.

Language: Английский

Citations

15
Preclinical study of inetetamab combined with atezolizumab to synergistically inhibit HER2 and PD-L1 in the treatment of ovarian cancer DOI Creative Commons

Feiquan Ying,

Xuyang Zhou,

Mengqing Chen

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 33(1), P. 200938 - 200938

Published: Jan. 18, 2025

Epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy. Precision treatments are crucial for improving patient survival. This research explored potential anti-tumor effects of combining inetetamab and atezolizumab HER2+ EOC patients. The expressions human epidermal growth factor receptor 2 (HER2) programmed cell death ligand 1 (PD-L1) in cells were evaluated. cell-derived subcutaneous peritoneal dissemination mouse models used to evaluate inetetamab, with or without atezolizumab. correlations between HER2 PD-L1 as well infiltration T tumors from patients mice analyzed by immunohistochemistry. Inetetamab suppressed models. overexpression increased levels cells. expression level positively related that both CD4+ CD8+ combination impeded vivo induced a long-term effect elevated CD103+CD8+ These findings suggest could be promising precision treatment strategy

Language: Английский

Citations

1
Efficacy and safety of different drugs in patients with HER2-positive gastric cancer: network meta-analysis DOI Creative Commons
Jie Zhang, Chunluan Yuan, Xiao Ma

et al.

Systematic Reviews, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 10, 2025

In the past decade, there has been a significant advancement in targeted therapy and immunotherapy, leading to discovery of new drugs changes treatment approach for patients with HER2-positive gastric cancer. Although several are available treating these patients, is still no consensus on their selection, limited direct or indirect comparison among them. To address this gap, network meta-analysis was conducted assess efficacy safety different used By searching through databases such as PubMed, Embase, Web Science, Cochrane Library, we identified 16 randomized controlled trials that involved total 4485 utilized 9 intervention measures. Based current evidence, compared chemotherapy alone, hazard ratio (HR) overall survival (OS) progression-free (PFS) cancer treated nivolumab were [hazard (HR): 2.61 95%confidence interval (CI) (1.51, 4.51)] 2.01 95% confidence (1.18, 3.42)], respectively. Compared trastuzumab deruxtecan 1.7 (1.13, 2.56)] 2.13 (1.42, 3.22)], It suggested can effectively prolong survival(PFS) cancer, while also reducing risk adverse events some extent. Therefore, two regimens, deruxtecan, considered be effective safe options previous studies, trastuzumab-based common certain extent, our study provides reliable direction future PROSPERO CRD42023420941

Language: Английский

Citations

1
Napabucasin deactivates STAT3 and promotes mitoxantrone-mediated cGAS-STING activation for hepatocellular carcinoma chemo-immunotherapy DOI
Lingzhi Wang, Shengnan Bi, Zhuo Li

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122766 - 122766

Published: Aug. 22, 2024

Language: Английский

Citations

8
Evaluation of peripheral blood inflammation indexes as prognostic markers for colorectal cancer metastasis DOI Creative Commons
Xin Shen,

Mengying Xiang,

Jiadai Tang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 3, 2024

The aim of this study was to evaluate the prognostic value peripheral blood inflammation indexes in patients with metastatic Colorectal Cancer (CRC) and establish a predictive scoring system. A total 324 CRC diagnosed through pathological examination from January 2017 July 2022 at Third Affiliated Hospital Kunming Medical University were included. prognosis examined, correlation between IL-10 expression tissues serum analyzed. results showed that poorer when metastasis occurred (P < 0.001). Additionally, highly expressed group = 0.018), positively correlated 0.037). neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-white cell (LWR), aggregate index systemic (AISI), monocyte-to-lymphocyte (MLR), inflammatory response (SIRI), nutritional (PNI), advanced lung cancer (ALI), interleukin-10 (IL-10) calculated determined by ROC curve. critical values 2.135, 3.735, 353.745, 0.265, 1.025, 52.975, 353.635, 11.25, respectively. Inflammatory an AUC more than 0.6 selected, each colorectal patient any these risk factors assigned score one. then divided into two groups: 0–4 for low-risk 4–8 high-risk group. occurrence distant metastases groups statistically OS PFS significantly superior those 0.05). These findings indicate NLR, LWR, AISI, MLR, SIRI, PNI, ALI, are patients. Therefore, prediction scores can be used effectively CRC.

Language: Английский

Citations

6
Myeloid cell differentiation-related gene signature for predicting clinical outcome, immune microenvironment, and treatment response in lung adenocarcinoma DOI Creative Commons
Di Wu, Yibing Liu, Jianjun Liu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 29, 2024

Considering the key role of myeloid cell differentiation—related genes in tumor microenvironment (TME), we aimed to build a prognostic risk model using these for Lung adenocarcinoma (LUAD). The mRNA gene expression profiles LUAD patients from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were downloaded as training validation sets. Then, "edgeR" R package was applied screen out differentially expressed (DEGs) univariate cox regression, backward stepwise selection analyses performed construct LUAD. ESTIMATE, TIMER, XCELL, CIBERSORT abs, QUANTISEQ, MCPCOUNTER, EPIC, algorithms conducted access association levels with stromal immune infiltration Six (F2RL1, PRKDC, TNFSF11, INHA, PLA2G3 TUBB1) utilized model. showed excellent performance both TCGA GEO datasets. Also, compared low-risk patients, high-risk had higher checkpoint molecules lower IC50 value chemotherapy agents. Our findings provided signature that could effectively predict prognosis guide treatment strategies patients.

Language: Английский

Citations

5
Explainable machine learning models for early gastric cancer diagnosis DOI Creative Commons
Hongyang Du,

Qingfen Yang,

Aimin Ge

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 29, 2024

Gastric cancer remains a significant global health concern, with notably high incidence in East Asia. This paper explores the potential of explainable machine learning models enhancing early diagnosis gastric cancer. Through comprehensive evaluations, various models, including WeightedEnsemble, CatBoost, and RandomForest, demonstrated accurately diagnosing The study emphasizes importance model explainability medical diagnostics, showing how transparent, can increase trust clinical acceptance, thereby improving diagnostic accuracy patient outcomes. research not only highlights key biomarkers features critical for detection but also presents versatile approach that could be applied to other promoting broader adoption settings.

Language: Английский

Citations

5
Bioinformatics analysis to disclose shared molecular mechanisms between type-2 diabetes and clear-cell renal-cell carcinoma, and therapeutic indications DOI Creative Commons

Reaz Ahmmed,

Md. Bayazid Hossen,

Alvira Ajadee

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 19, 2024

Type 2 diabetes (T2D) and Clear-cell renal cell carcinoma (ccRCC) are both complicated diseases which incidence rates gradually increasing. Population based studies show that severity of ccRCC might be associated with T2D. However, so far, no researcher yet investigated about the molecular mechanisms their association. This study explored T2D causing shared key genes (sKGs) from multiple transcriptomics profiles to investigate common pathogenetic processes drug molecules. We identified 259 differentially expressed (sDEGs) can separate patients control samples. Local correlation analysis on expressions sDEGs indicated significant association between ccRCC. Then ten (CDC42, SCARB1, GOT2, CXCL8, FN1, IL1B, JUN, TLR2, TLR4, VIM) were selected as sKGs through protein-protein interaction (PPI) network analysis. These found significantly different CpG sites DNA methylation cause The sKGs-set enrichment Gene Ontology (GO) terms KEGG pathways revealed some crucial functions, biological process, cellular components development regulatory six post-transcriptional regulators (hsa-mir-93-5p, hsa-mir-203a-3p, hsa-mir-204-5p, hsa-mir-335-5p, hsa-mir-26b-5p, hsa-mir-1-3p) five transcriptional (YY1, FOXL1, FOXC1, NR2F1 GATA2) sKGs. Finally, sKGs-guided top-ranked three repurposable molecules (Digoxin, Imatinib, Dovitinib) recommended treatment for by docking ADME/T Therefore, results this may useful diagnosis therapies who also suffering

Language: Английский

Citations

5