Major pathways involved in macrophage polarization in cancer

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 17, 2022

Macrophages play an important role in tissue homeostasis, remodeling, immune response, and progression of cancer. Consequently, macrophages exhibit significant plasticity change their transcriptional profile function response to environmental, tissue, inflammatory stimuli resulting pro- anti-tumor effects. Furthermore, the categorization situations remains difficult; however, there is agreement that are predominantly polarized into two different subtypes with anti-inflammatory properties, so-called M1-like M2-like macrophages, respectively. These macrophage classes can be considered as extreme borders a continuum many intermediate subsets. On one end, M1 pro-inflammatory initiate immunological damage integrity, dampen tumor by fostering robust T natural killer (NK) cell anti-tumoral responses. other M2 involved remodeling growth, promote cancer proliferation, invasion, metastasis, angiogenesis participate suppression. decisive roles occur through secretion cytokines, chemokines, growth factors, matrix metalloproteases, well expression checkpoint receptors case macrophages. Moreover, supported from Tumor Microenvironment (TME) relayed nucleus membrane signaling pathways result gene reprogramming thus giving rise polarization outcomes. In this review, we will focus on main activated upon ligand-receptor recognition presence immunomodulatory molecules

Language: Английский

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Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(9)

Published: June 20, 2022

Language: Английский

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The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer

Cancer Management and Research, Journal Year: 2022, Volume and Issue: Volume 14, P. 1 - 17

Published: Jan. 1, 2022

Abstract: Triple-negative breast cancer (TNBC) is a special subtype of cancer, accounting for 10– 20% cancers with high intrinsic heterogeneity. Its unique immune microenvironment, including expression vascular endothelial growth factors, tumor infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and other molecules that promote the migration cells, has been shown to play dual role in occurrence, growth, metastasis TNBC. Understanding TNBC microenvironment great significance prognosis treatment In this article, we describe composition function cells summarize major cytokine factors chemokines microenvironment. Finally, discuss progress TNBC, cytokine-induced killer cell therapy, checkpoint therapy. Keywords: triple negative immunotherapy

Language: Английский

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The role of tumor microenvironment in drug resistance: emerging technologies to unravel breast cancer heterogeneity

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: May 17, 2023

Breast cancer is a highly heterogeneous disease, at both inter- and intra-tumor levels, this heterogeneity crucial determinant of malignant progression response to treatments. In addition genetic diversity plasticity cells, the tumor microenvironment contributes shaping physical biological surroundings tumor. The activity certain types immune, endothelial or mesenchymal cells in can change effectiveness therapies via plethora different mechanisms. Therefore, deciphering interactions between distinct cell types, their spatial organization specific contribution growth drug sensitivity still major challenge. Dissecting currently an urgent need better define breast biology develop therapeutic strategies targeting as helpful tools for combined personalized treatment. review, we analyze mechanisms by which affects characteristics that ultimately result resistance, outline state art preclinical models emerging technologies will be instrumental unraveling impact on resistance therapies.

Language: Английский

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Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 12, 2024

The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate progression anti-tumor immunity. It now evident that the within TME significantly contribute resistance conventional newly developed therapies. Both in play critical roles onset, uncontrolled proliferation, metastasis, evasion, Consequently, molecular cellular components of have emerged as promising therapeutic targets for developing novel treatments. primarily comprises cells, stromal vasculature, infiltrating cells. Currently, numerous clinical trials targeting specific are underway. However, complexity its impact on evasion immunity necessitate further research develop improved multifaceted nature arises from their phenotypic functional plasticity, which endows them both pro during progression. In this review, we discuss current understanding recent advances anti-tumoral functions implications safe effective therapies control progress.

Language: Английский

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The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities

Cellular Oncology, Journal Year: 2021, Volume and Issue: 44(6), P. 1209 - 1229

Published: Sept. 16, 2021

Language: Английский

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Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(6)

Published: April 29, 2022

Language: Английский

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Chemokines in triple-negative breast cancer heterogeneity: New challenges for clinical implications

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 769 - 783

Published: March 9, 2022

Language: Английский

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Expression pattern and prognostic significance of baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) in breast cancer: A comprehensive analysis

Advances in Cancer Biology - Metastasis, Journal Year: 2022, Volume and Issue: 4, P. 100037 - 100037

Published: March 23, 2022

Baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, member the (IAP), is a multitasking protein and among top 100 deregulated genes in breast cancer patients. It negatively regulates tumor cells by inducing gene expression anti-apoptotic proteins, promoting cell proliferation, modulates response to chemotherapeutics. The main objective study was analyze pattern, prognostic significance functional role BIRC5 (BC). In present study, we utilized bioinformatic approach, pattern BC explore interactions tumorigenicity. mRNA levels were augmented carcinoma & over-expression found associated with poor overall survival (OS) relapse-free (RFS). KEGG pathway ontology analysis indicate that highly enriched mitotic pathways pathways. PPI correlation further revealed showed high oncogenic proteins. Moreover, infiltration myeloid derived suppressor (MDSCs) stroma. Cumulatively, this signifies promotes progression, targeting combination conventional therapies will significantly enhance patients therapy.

Language: Английский

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Targeting tumor microenvironment using tumor-infiltrating lymphocytes as therapeutics against tumorigenesis

Immunologic Research, Journal Year: 2023, Volume and Issue: 71(4), P. 588 - 599

Published: April 1, 2023

Language: Английский

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