Virome in the Lungs: The Role of Anelloviruses in Childhood Respiratory Diseases DOI Creative Commons

Giulia Dodi,

Marina Attanasi, Paola Di Filippo

et al.

Microorganisms, Journal Year: 2021, Volume and Issue: 9(7), P. 1357 - 1357

Published: June 23, 2021

More recently, increasing attention has been directed to exploring the function of global virome in health and disease. Currently, by new molecular techniques, such as metagenomic DNA sequencing, better unveiled. By investigating human lung virome, we could provide novel insights into respiratory diseases. The a part microbiome, is characterized constant change composition related type diet, environment, our genetic code, other incalculable factors. plays substantial role modulating immune defenses contributing inflammatory processes. Anelloviruses (AVs) are components virome. AVs already present during early life reproduce without apparently causing harm host. still unknown, but several reports have shown that activate inflammasomes, intracellular multiprotein oligomers innate system, which show crucial host defense pathogens. In this narrative revision, summarize epidemiological data possible link between microbial alterations chronic diseases children. Briefly, also describe characteristics most frequent viral family Anelloviridae. Furthermore, discuss how modulate system children, affecting development diseases, particularly asthma, common disease childhood.

Language: Английский

Advances and highlights in biomarkers of allergic diseases DOI
İsmail Öğülür, Yağız Pat, Özge Ardıçlı

et al.

Allergy, Journal Year: 2021, Volume and Issue: 76(12), P. 3659 - 3686

Published: Sept. 14, 2021

During the past years, there has been a global outbreak of allergic diseases, presenting considerable medical and socioeconomical burden. A large fraction diseases is characterized by type 2 immune response involving Th2 cells, innate lymphoid eosinophils, mast M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on disease endotypes, clusters, diagnoses, identification therapeutic targets, monitoring treatment efficacies. The availability powerful omics technologies, together with integrated data analysis network-based approaches can help clinically useful biomarkers. These biomarkers need to be accurately quantified using robust reproducible methods, such reliable point-of-care systems. Ideally, samples should collected quick, cost-efficient noninvasive methods. In recent plethora research directed toward finding novel diseases. Promising include sputum serum periostin exhaled nitric oxide. Several other biomarkers, pro-inflammatory mediators, miRNAs, eicosanoid molecules, epithelial barrier integrity, microbiota changes diagnosis in serum, body fluids air. Herein, we review studies asthma, chronic urticaria, atopic dermatitis, rhinitis, rhinosinusitis, food allergies, anaphylaxis, drug hypersensitivity allergen immunotherapy. addition, discuss COVID-19 within perspective recommendations management asthmatic patients during pandemic.

Language: Английский

Citations

150
Allergy: Mechanistic insights into new methods of prevention and therapy DOI
Cezmi A. Akdiş, Mübeccel Akdiş, Scott D. Boyd

et al.

Science Translational Medicine, Journal Year: 2023, Volume and Issue: 15(679)

Published: Jan. 18, 2023

In the past few decades, prevalence of allergic diseases has increased worldwide. Here, we review etiology and pathophysiology diseases, including role epithelial barrier, immune system, climate change, pollutants. Our current understanding roles early life infancy; diverse diet; skin, respiratory, gut barriers; microbiome in building tolerance to common environmental allergens led changes prevention guidelines. Recent developments on mechanisms involved have been translated effective treatments, particularly 5 years, with additional treatments now advanced clinical trials.

Language: Английский

Citations

44
Asthma in COVID-19 Hospitalizations: An Overestimated Risk Factor? DOI Creative Commons
Richard Broadhurst, Ryan A. Peterson, Juan P. Wisnivesky

et al.

Annals of the American Thoracic Society, Journal Year: 2020, Volume and Issue: 17(12), P. 1645 - 1648

Published: Aug. 31, 2020

Language: Английский

Citations

72
Cytokine Storm and Mucus Hypersecretion in COVID-19: Review of Mechanisms DOI Creative Commons
Mohsin Ali Khan, Zaw Ali Khan, Mark Charles

et al.

Journal of Inflammation Research, Journal Year: 2021, Volume and Issue: Volume 14, P. 175 - 189

Published: Jan. 1, 2021

Abstract: Mucus is an integral part of the respiratory physiology. It protects tract by acting as a physical barrier against inhaled particles and microbes. Excessive inflammation in conditions such COVID-19 can result over-production mucus which obstructs airway. Build-up also contribute to recurrent airway infection, causing further obstruction. This article summarizes current understanding knowledge production proposes role cytokine storm inducing sudden hypersecretion COVID-19. Based on these cascades, active constituents that inhibit or activate several potential targets are outlined for research. These may be explored discovery design drugs combat its ensuing complications. Keywords: COVID-19, storm, mucus, coronavirus, viral infection

Language: Английский

Citations

61
Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19 DOI Creative Commons
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 22, 2023

Abstract Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. We analyse mechanisms response to viral in experimental vivo rhinovirus healthy controls patients asthma, vitro experiments mite, SARS-CoV-2 human primary epithelium. Here, we show that leads an excessive RIG-I inflammasome activation, which diminishes its accessibility type I/III interferon responses, leading their early functional impairment, delayed resolution, prolonged clearance unresolved vivo. Pre-exposure augments this phenomenon by priming auxiliary inhibition responses. Prior followed activation epithelial inflammation. Timely may lead more efficient lower burden infections.

Language: Английский

Citations

29
Respiratory Syncytial Virus Infection: An Update DOI

Akshita Soni,

S. K. Kabra,

Rakesh Lodha

et al.

The Indian Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 90(12), P. 1245 - 1253

Published: June 16, 2023

Language: Английский

Citations

29
The Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic DOI Creative Commons

Talia Amram,

Or Duek, Inbal Golan‐Tripto

et al.

Pediatric Pulmonology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Respiratory syncytial virus (RSV) infection in the first year of life has been linked with an increased risk for asthma. Some propose that RSV-induced inflammation leads to lasting airway changes, while others contend RSV bronchiolitis is a marker underlying predisposition. Social distancing adopted during COVID-19 pandemic led dramatic reduction activity, providing unexpected opportunity investigate this debate.

Language: Английский

Citations

1
Asthmatic patients in COVID-19 outbreak: Few cases despite many cases DOI Creative Commons
Marco Caminati, Carlo Lombardi, Claudio Micheletto

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2020, Volume and Issue: 146(3), P. 541 - 542

Published: June 22, 2020

Language: Английский

Citations

51
The Human Respiratory Microbiome: Current Understandings and Future Directions DOI Creative Commons
Lan Zhao, Jun-Li Luo, Md Khadem Ali

et al.

American Journal of Respiratory Cell and Molecular Biology, Journal Year: 2022, Volume and Issue: 68(3), P. 245 - 255

Published: Dec. 7, 2022

Section:ChooseTop of pageAbstract <

Language: Английский

Citations

37
Recent miRNA Research in Asthma DOI Creative Commons
Rinku Sharma, Anshul Tiwari, Michael J. McGeachie

et al.

Current Allergy and Asthma Reports, Journal Year: 2022, Volume and Issue: 22(12), P. 231 - 258

Published: Dec. 1, 2022

The study of microRNA in asthma has revealed a vibrant new level gene regulation underlying pathology. Several miRNAs have been shown to be important asthma, influencing various biological mechanisms which lead pathology and symptoms. In addition, proposed as biomarkers affection status, severity, treatment response. We review all recent asthma-miRNA work, while also presenting comprehensive tables miRNA results related asthma.We here reviewed 63 studies published reporting research, an additional 14 reviews the same. summarized information for both adult childhood well research on asthma-COPD overlap syndrome (ACOs), virus-induced exacerbations. attempted present collection recently asthma-associated asthma-related results.

Language: Английский

Citations

34