Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1495 - 1495
Published: July 22, 2024
Subgroup J avian leukosis virus (
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(5), P. 2567 - 2588
Published: Nov. 2, 2023
Language: Английский
Citations
40
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 198, P. 114858 - 114858
Published: May 12, 2023
Language: Английский
Citations
20
Cells, Journal Year: 2023, Volume and Issue: 12(19), P. 2421 - 2421
Published: Oct. 9, 2023
Respiratory diseases represent a significant economic and health burden worldwide, affecting millions of individuals each year in both human animal populations. MicroRNAs (miRNAs) play crucial roles gene expression regulation are involved various physiological pathological processes. Exosomal miRNAs cellular have been identified as key regulators several immune respiratory diseases, such chronic (CRD) caused by Mycoplasma gallisepticum (MG), pneumoniae pneumonia (MMP) the bacterium pneumoniae, coronavirus disease 2019 (COVID-19), obstructive pulmonary (COPD), asthma, acute lung injury/acute distress syndrome (ALI/ARDS). Consequently, seem to potential serve diagnostic biomarkers therapeutic targets diseases. In this review, we summarize current understanding functional above discuss use stable for focusing on identification differentially expressed their targeting signaling pathways implicated pathogenesis. Despite progress made, unanswered questions future research directions discussed facilitate personalized targeted therapies patients with these debilitating conditions.
Language: Английский
Citations
11
Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 104 - 104
Published: Jan. 12, 2025
Asthma is a major non-communicable disease whose pathogenesis still not fully elucidated. One of the asthma research models precision-cut lung slices (PCLSs), and among therapeutic options, miRNA molecules are great interest. The aim our study was to investigate whether inhibition miR-223-3p miR328a-3p affects inflammatory response in PCLSs derived from rat with HDM-induced allergic inflammation control rat. We generated transfected them miR-328a-3p inhibitors. RNA isolated analyzed by qPCR. also examined proteins culture medium using Magnetic Luminex Assay. comparison between miRNA-transfected non-transfected controls showed significant differences expression several genes associated inflammation, including Il-33, Ccl5, Prg2 Tslp, both In medium, we found no protein levels control. Our highlighted some important issues: need extend model more biological replicates, standardize conditions, consider co-transfection inhibitors when modifying miRNAs PCLS model.
Language: Английский
Citations
0
Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3570 - 3570
Published: April 10, 2025
Asthma and atherosclerosis are chronic conditions with distinct pathophysiologies, but overlapping inflammatory mechanisms that suggest a potential common regulatory framework. MicroRNAs (miRNAs), small non-coding RNA molecules modulate gene expression post-transcriptionally, could be key players in linking these disorders. This review outlines how miRNAs contribute to the complex interplay between asthma atherosclerosis, focusing on involved pathways, immune cell regulation vascular remodeling. We discuss specific miRNAs, such as miR-155, miR-21 miR-146a, which have been shown cytokine production T differentiation, impacting respiratory cardiovascular health. The found both emphasize their role biomarkers, also therapeutic targets. Understanding molecular connections may unlock novel approaches for innovative, integrated treatment strategies address significantly improve patient outcomes. Further research is needed explore mechanistic pathways validate translational of miRNA-based interventions preclinical clinical settings.
Language: Английский
Citations
0
Journal of Cardiothoracic Surgery, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 23, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11499 - 11499
Published: July 15, 2023
Asthma is a chronic inflammatory disease of the airways characterized by shortness breath, chest tightness, coughing, and wheezing. For several decades (approximately 30 years), miRNAs their role in asthma have been constant interest among scientists. These small, non-coding RNA fragments, 18–25 nucleotides long, regulate gene expression at post-transcriptional level binding to target mRNA. In this way, they affect biological processes, e.g., shaping airway structures, producing cytokines immune mediators, controlling defense mechanisms. Publications confirm potential diagnosis monitoring disease, but only some articles address use treatment asthma. The following paper reviews latest available studies presents as useful tool for predicting effectiveness included treatment, early exacerbations, assessing patient compliance different groups drugs used known pathways underlying pathogenesis which are associated with change miRNA expression, may be precise targets therapeutic activity future.
Language: Английский
Citations
8
Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 155054 - 155054
Published: Dec. 22, 2023
Language: Английский
Citations
7
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155147 - 155147
Published: Jan. 19, 2024
Language: Английский
Citations
2