Association of maternal infection of SARS-CoV-2 and neonatal susceptibility: A retrospective cohort study DOI Creative Commons
Xiaodan Zhu,

Yanjie Peng,

Ying Chen

et al.

Vaccine X, Journal Year: 2024, Volume and Issue: 20, P. 100536 - 100536

Published: July 27, 2024

This study aims to assess the risk of neonatal susceptibility COVID-19 among pregnant women. We conducted a retrospective cohort involving 1089 women ≥28 weeks gestational age, who were categorized into infected and uninfected groups. Data for all participants collected through comprehensive review electronic medical records follow-up phone calls. The primary outcome was infection with SARS-CoV-2, while secondary outcomes included delivery patterns age at delivery. Maternal vaccination (OR 95%CI:0.63[0.46, 0.85]) maternal SARS-CoV-2 95%CI: 0.45[0.34, 0.60]) found be associated decreased infection. group exhibited lower rate (25.93%) compared (45.15%). Logistic regression analysis identified several factors an increased infection, including pregnancy BMI 1.04[1.01, 1.08]), first 1.05[1.01, 1.10]), menarche 1.13[1.02, 1.26]), parturition (Yes vs. No) 95%CI:1.4 [1.04,1.88]). perinatal play protective role in preventing

Language: Английский

Detection and discrimination of SARS-CoV-2 spike protein-derived peptides using THz metamaterials DOI Creative Commons
Soo Hyun Lee, Yeon Kyung Lee, Sang‐Hun Lee

et al.

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 202, P. 113981 - 113981

Published: Jan. 14, 2022

The development of effective assay techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently received research attention due to its rapid worldwide spread and considerable risk human health. receptor-binding domain (RBD) the spike (S) protein in SARS-CoV-2, a key component viral entry that unique sequence compared other structural proteins, been considered an important diagnostic target. In this respect, low-frequency vibrational modes have advantage providing information about compositional dependencies at peptide level. study, sensitive selective detection peptides derived from RBD SARS-CoV-2 SARS-CoV was investigated using metamaterial-based sensing chips with terahertz time-domain spectroscopy (THz-TDS) system. Based on their sequences, two pairs 20 residues each were prepared. sensitivity, specificity, reproducibility proposed system examined via quantitative analysis THz metamaterials three resonance frequencies, it found species could be discriminated based sequences. signals analyzed regard major amino acid components peptides, molecular distributions also hydropathy net charge peptides.

Language: Английский

Citations

43
Emergence of SARS-CoV-2 New Variants and Their Clinical Significance DOI Creative Commons
Hitesh Singh,

Nisha Dahiya,

Mahima Yadav

et al.

Canadian Journal of Infectious Diseases and Medical Microbiology, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 8

Published: May 28, 2022

COVID-19 is a respiration-related disease caused by SARS-CoV-2 and was identified in China’s Wuhan city. More than 223 countries are affected the worldwide. The new variants of virus causing problems, from average to life-threatening pneumonia acute respiratory distress syndrome (ARDS). Presently, there 170 vaccine candidates, out which 10 have been approved WHO for vaccination, such as Ad26.COV2.S, Pfizer/BioNTech, COVISHIELD, Covovax, Moderna, KoviVac, some other vaccines combat deadly infection. From all these vaccines, Pfizer/BioNTech Moderna showing highest efficacy against COVID-19. These highly efficient disease, but their potentiality remains question. effective at preventing severe illnesses, hospitalizations, death. antibodies elicited earlier infection or vaccination key possible protection SARS-CoV-2. problem has exacerbated information Africa on origins novel contagious strain. strains occur due unique mutations spike protein, modify transmission capabilities, limiting vaccination. Hence, need find potential it.

Language: Английский

Citations

33
Natural products as potential lead compounds to develop new antiviral drugs over the past decade DOI

Jing-Han Zhao,

Yuewei Wang, Jin Yang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 260, P. 115726 - 115726

Published: Aug. 15, 2023

Language: Английский

Citations

20
Adverse reactions to COVID‐19 vaccines: A practical approach DOI Open Access
Krzysztof Rutkowski,

Rita Mirakian,

Stephen J. Till

et al.

Clinical & Experimental Allergy, Journal Year: 2021, Volume and Issue: 51(6), P. 770 - 777

Published: April 4, 2021

COVID-19-related mortality in high-risk individuals is substantial and current treatment options are limited. There convincing evidence that the COVID-19 vaccines reduce severity of infection prevent deaths. Three approved United Kingdom with many more development. limited data on triggers mechanisms anaphylaxis to these vaccines. We review potential allergenic compounds describe an innovative allergy support model for vaccination hubs allows most patients severe be immunized. Finally, we propose a practical algorithm investigations

Language: Английский

Citations

41
S-adenosylmethionine-dependent methyltransferase inhibitor DZNep blocks transcription and translation of SARS-CoV-2 genome with a low tendency to select for drug-resistant viral variants DOI Open Access
Ram Kumar, Nitin Khandelwal, Yogesh Chander

et al.

Antiviral Research, Journal Year: 2021, Volume and Issue: 197, P. 105232 - 105232

Published: Dec. 29, 2021

Language: Английский

Citations

33
Plant-Derived Antimicrobial Peptides as Potential Antiviral Agents in Systemic Viral Infections DOI Creative Commons
Nour Mammari, Ysaline Krier, Quentin Albert

et al.

Pharmaceuticals, Journal Year: 2021, Volume and Issue: 14(8), P. 774 - 774

Published: Aug. 6, 2021

Numerous studies have led to a better understanding of the mechanisms action viruses in systemic infections for development prevention strategies and very promising antiviral therapies. Viruses still remain one main causes human diseases, mainly because new vaccines is usually challenging drug resistance has become an increasing concern recent decades. Therefore, potential agents remains crucial unmet clinical need. One abundant source therapeutic molecules are plants: they biosynthesize myriad compounds, including peptides which can antimicrobial activity. Our objective summarize literature on with properties derived from plants identify key features these their application viral infections. This review highlights trials demonstrated that plant cyclotides ability inhibit growth causing defensin-like possess anti-HIV-1 activity, lipid transfer proteins some lectins exhibit varied profile. To conclude, interesting explore context emerging re-emerging infectious diseases.

Language: Английский

Citations

30
The Development of Aptamer-Based Gold Nanoparticle Lateral Flow Test Strips for the Detection of SARS-CoV-2 S Proteins on the Surface of Cold-Chain Food Packaging DOI Creative Commons
Xiaotong Li, Jiachen Wang, Ge Yang

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1776 - 1776

Published: April 13, 2024

The COVID-19 pandemic over recent years has shown a great need for the rapid, low-cost, and on-site detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, an aptamer-based colloidal gold nanoparticle lateral flow test strip was well developed to realize visual wild-type SARS-CoV-2 spike proteins (SPs) multiple variants. Under optimal reaction conditions, low limit S 0.68 nM acquired, actual recovery 83.3% 108.8% real-world samples. This suggests potential tool prompt with good sensitivity accuracy, new method development alternative antibody strips other viral targets.

Language: Английский

Citations

3
The Remarkable Roles of the Receptor for Advanced Glycation End Products (RAGE) and Its Soluble Isoforms in COVID-19: The Importance of RAGE Pathway in the Lung Injuries DOI Open Access
Mitra Salehi, Shahin Amiri,

Dariush Ilghari

et al.

Indian Journal of Clinical Biochemistry, Journal Year: 2022, Volume and Issue: 38(2), P. 159 - 171

Published: Aug. 18, 2022

Language: Английский

Citations

15
3D interior hotspots embedded with viral lysates for rapid and label-free identification of infectious diseases DOI Creative Commons
Soo Hyun Lee,

Iris Baffour Ansah,

Won‐Chul Lee

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 454, P. 140066 - 140066

Published: Oct. 29, 2022

• The 3D interior organo-hotspots was demonstrated via electrochemical deposition onto Au nanodimple platforms with viral lysates. proposed platform exhibited the label-free SERS detection of SARS-CoV-2 traced real clinical samples in a sensitive, quantitative, and reliable manner. In recent decades, biomedical sensors based on surface-enhanced Raman spectroscopy (SERS), which reveals unique spectral features corresponding to individual molecular vibrational states, have attracted intensive attention. However, lack system for precisely guiding biomolecules active hotspot regions has impeded broad application techniques. Herein, we demonstrate irreversible engineering three-dimensional (3D) (EC) metal (ECOMD) This approach enables organic seed-programmable growth spontaneous bottom-up formation simultaneously. Because net charge effect participation rate lysates, number ECOMDs increases increasingly positive polarity. lysates embedded function as both dielectric medium field confinement an analyte, enabling highly specific sensitive (SLs) at concentrations low 10 –2 plaque forming unit/mL. ECOMD used trace detect SLs human saliva diagnose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); results indicate that can provide point-of-care diagnoses infectious diseases.

Language: Английский

Citations

15
Development of Aptamer-Based Gold Nanoparticle Lateral Flow Test Strips for Detection of SARS-CoV-2 S Protein on the Surface of Cold Chain Food Packaging DOI Open Access
Xiaotong Li, Jiachen Wang, Xiaona Fang

et al.

Published: Feb. 20, 2024

The COVID-19 pandemic over the past years has shown a great need for rapid, low-cost and on-site detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this paper, an aptamer-based colloidal gold nanoparticle lateral flow test strip was well developed to realize visual wild type SARS-CoV-2 spike protein (SP) multiple variants. Under optimal reaction conditions, low limit S 0.68 nM acquired, actual recovery 83.3% 108.8% real world samples. This suggests potential tool prompt with good sensitivity accuracy, new method development alternative antibody strips other viral targets.

Language: Английский

Citations

3