Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(15)
Published: Feb. 22, 2024
Abstract
Amyloid
beta‐protein
(AβA
β
)
is
a
main
hallmark
of
Alzheimer's
disease
(AD),
and
low
amount
Aβ
protein
accumulation
appears
to
be
potential
marker
for
AD.
Here,
an
electrochemical
DNA
biosensor
based
on
polyamide/polyaniline
carbon
nanotubes
(PA/PANI‐CNTs)
developed
with
the
aim
diagnosing
AD
early
using
simple,
low‐cost,
accessible
method
rapidly
detect
Aβ42
in
human
blood.
Electrospun
PA
nanofibers
served
as
skeleton
successive
situ
deposition
PANI
CNTs,
which
contribute
both
high
conductivity
abundant
binding
sites
aptamers.
After
aptamers
are
immobilized,
this
aptasensor
exhibits
precise
specific
detection
blood
within
only
4
min
extremely
fast
response
rate,
lower
limit,
excellent
linear
range.
These
findings
make
significant
contribution
advancing
development
serum‐based
techniques
Aβ42,
thereby
paving
way
improved
diagnostic
capabilities
field
Molecular Biomedicine,
Journal Year:
2022,
Volume and Issue:
3(1)
Published: Dec. 8, 2022
Vaccines
are
one
of
the
most
effective
medical
interventions
to
combat
newly
emerging
and
re-emerging
diseases.
Prophylactic
vaccines
against
rabies,
measles,
etc.,
have
excellent
effectiveness
in
preventing
viral
infection
associated
However,
host
immune
response
is
unable
inhibit
virus
replication
or
eradicate
established
diseases
infected
people.
Therapeutic
vaccines,
expressing
specific
endogenous
exogenous
antigens,
mainly
induce
boost
cell-mediated
immunity
via
provoking
cytotoxic
T
cells
elicit
humoral
activating
B
produce
antibodies.
The
ultimate
aim
a
therapeutic
vaccine
reshape
for
eradicating
disease
establishing
lasting
memory.
Therefore,
been
developed
treatment
some
infectious
chronic
noncommunicable
Various
technological
strategies
implemented
development
including
molecular-based
(peptide/protein,
DNA
mRNA
vaccines),
vector-based
(bacterial
vector
yeast-based
vaccines)
cell-based
(dendritic
cell
genetically
modified
as
well
combinatorial
approaches.
This
review
summarizes
vaccine-induced
describes
status
multiple
types
diseases,
such
those
caused
by
HPV,
HBV,
HIV,
HCV,
SARS-CoV-2,
cancer,
hypertension,
Alzheimer's
disease,
amyotrophic
lateral
sclerosis,
diabetes,
dyslipidemia,
that
evaluated
recent
preclinical
clinical
studies.
Aggregate,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: March 10, 2023
Abstract
Protein
amyloid
aggregation
has
been
widely
observed
to
occur
and
plays
important
roles
in
both
physiological
processes
pathological
diseases.
Remarkably,
aggregates
assembled
by
native
proteins
gain
a
variety
of
different
biological
activities,
which
cannot
be
adopted
the
unassembled
protein
alone.
Thus,
it
is
investigate
molecular
basis
self‐assembly
how
aggregated
structure
determines
its
function.
In
review,
we
firstly
introduce
our
structural
knowledge
on
undergo
conformational
transition
assemble
into
aggregate,
with
main
focus
fibril,
major
species
aggregate.
Then,
elaborate
structures
fibrils
enable
them
fulfill
highly
diverse
functions
either
or
condition.
Furthermore,
discuss
polymorph
very
unique
feature
implication
understanding
structure‐function
relationship
fibrils.
Finally,
point
out
importance
applying
integrating
new
approaches
for
deepening
study
highlight
potential
designing
fibril‐based
functional
bio‐nanomaterials
application.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(2), P. 355 - 355
Published: Jan. 26, 2023
Early
cognitive
decline
in
patients
with
Alzheimer's
(AD)
is
associated
quantifiable
structural
and
functional
connectivity
changes
the
brain.
AD
dysregulation
of
Aβ
tau
metabolism
progressively
disrupt
normal
synaptic
function,
leading
to
loss
synapses,
decreased
hippocampal
density
early
atrophy.
Advances
brain
imaging
techniques
living
have
enabled
transition
from
clinical
signs
symptoms-based
diagnosis
biomarkers-based
diagnosis,
techniques,
quantitative
EEG,
body
fluids
sampling.
The
hippocampus
has
a
central
role
semantic
episodic
memory
processing.
This
function
critically
dependent
on
intrahippocampal
connections
many
cortical
regions,
including
perirhinal
entorhinal
cortex,
parahippocampal
association
regions
temporal
parietal
lobes,
prefrontal
cortex.
Therefore,
reflected
altered
intrinsic
networks
(aka
large-scale
networks),
memory,
default
mode,
salience
networks.
narrative
review
discusses
recent
critical
issues
related
detecting
AD-associated
markers
high-risk
or
neuropsychologically
diagnosed
subjective
impairment
mild
impairment.
Journal of Stroke,
Journal Year:
2024,
Volume and Issue:
26(1), P. 1 - 12
Published: Jan. 31, 2024
Cerebral
amyloid
angiopathy
(CAA)
has
been
proven
to
be
the
most
common
pathological
change
in
cerebral
small
vessel
disease
except
arteriosclerosis.
In
recent
years,
with
discovery
of
imaging
technology
and
new
markers,
diagnostic
rate
CAA
greatly
improved.
plays
an
important
role
non-hypertensive
hemorrhage
cognitive
decline.
This
review
comprehensively
describes
etiology,
epidemiology,
pathophysiological
mechanisms,
clinical
features,
manifestations,
criteria,
treatment
facilitate
its
diagnosis
reduce
mortality.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(15)
Published: Feb. 22, 2024
Abstract
Amyloid
beta‐protein
(AβA
β
)
is
a
main
hallmark
of
Alzheimer's
disease
(AD),
and
low
amount
Aβ
protein
accumulation
appears
to
be
potential
marker
for
AD.
Here,
an
electrochemical
DNA
biosensor
based
on
polyamide/polyaniline
carbon
nanotubes
(PA/PANI‐CNTs)
developed
with
the
aim
diagnosing
AD
early
using
simple,
low‐cost,
accessible
method
rapidly
detect
Aβ42
in
human
blood.
Electrospun
PA
nanofibers
served
as
skeleton
successive
situ
deposition
PANI
CNTs,
which
contribute
both
high
conductivity
abundant
binding
sites
aptamers.
After
aptamers
are
immobilized,
this
aptasensor
exhibits
precise
specific
detection
blood
within
only
4
min
extremely
fast
response
rate,
lower
limit,
excellent
linear
range.
These
findings
make
significant
contribution
advancing
development
serum‐based
techniques
Aβ42,
thereby
paving
way
improved
diagnostic
capabilities
field
