BNIP1 inhibits the fusion of autophagosome and lysosome in hippocampal neurons and promotes the development of Alzheimer's disease DOI Creative Commons
Chen Li, Miao Zhang, Hongyan Xia

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 7, 2024

Abstract Background BNIP1 (BCL2 interacting protein 1) is a soluble N-ethyl maleimide sensitive factor attachment receptor, and its decreased expression potentially associated with the occurrence development of Alzheimer's disease (AD), regulation has potential significance for prevention treatment AD. Methods The was detected in APP/PS1 transgenic mice APP-overexpressed HT22 hippocampal nerve cells. most relevant components were investigated by mass spectrometry. After using small interfering RNA plasmid to regulate BNIP1, detection results strengthened ensure accuracy reliability experiment. Results In our study, we that decrease double-transgenic cells inhibited fusion autophagosome lysosome, further induced Rab7 Rab5b recruitment. Overexpression can promote lysosome. knockdown resulted dysfunction lysosome Conclusions These suggest lead dysfusion AD while overexpression ultimately inducing recruit Rab7, which provides intervention target

Language: Английский

Inflammation and Organic Cation Transporters Novel (OCTNs) DOI Creative Commons
Lorena Pochini, Michele Galluccio, Lara Console

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 392 - 392

Published: March 25, 2024

Inflammation is a physiological condition characterized by complex interplay between different cells handled metabolites and specific inflammatory-related molecules. In some pathological situations, inflammation persists underlying worsening the state. Over years, two membrane transporters namely OCTN1 (SLC22A4) OCTN2 (SLC22A5) have been shown to play roles in inflammation. These form OCTN subfamily within larger SLC22 family. The link these proteins has proposed based on their chronic inflammatory diseases such as asthma, Crohn’s disease (CD), rheumatoid arthritis (RA). Moreover, show ability mediate transport of several compounds including carnitine, carnitine derivatives, acetylcholine, ergothioneine, gut microbiota by-products, which specifically associated with for anti- or proinflammatory action. Therefore, absorption distribution molecules rely presence OCTN2, whose expression modulated cytokines transcription factors typically activated present review, we wish provide state art function regulation relationships focusing metabolic signature collected body districts gene polymorphisms related diseases.

Language: Английский

Citations

5
Association of Egg Intake With Alzheimer’s Dementia Risk in Older Adults: The Rush Memory and Aging Project DOI

Yongyi Pan,

Taylor C. Wallace,

Tasija Karosas

et al.

Journal of Nutrition, Journal Year: 2024, Volume and Issue: 154(7), P. 2236 - 2243

Published: May 22, 2024

Language: Английский

Citations

5
Cholinergic Polarization of Human Macrophages DOI Open Access
Natalia Roa-Vidal,

Adriana S. Rodríguez-Aponte,

José A. Lasalde‐Dominicci

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15732 - 15732

Published: Oct. 29, 2023

Macrophages serve as vital defenders, protecting the body by exhibiting remarkable cellular adaptability in response to invading pathogens and various stimuli. These cells express nicotinic acetylcholine receptors, with α7-nAChR being extensively studied due its involvement activating cholinergic anti-inflammatory pathway. Activation of this pathway plays a crucial role suppressing macrophages' production proinflammatory cytokines, thus mitigating excessive inflammation maintaining host homeostasis. Macrophage polarization, which occurs specific or insults, is process that has received limited attention concerning activation contributions context. This review aims present evidence highlighting how constituents macrophages, led α7-nAChR, facilitate polarization macrophages towards phenotypes. Additionally, we explore influence viral infections on macrophage inflammatory phenotypes, taking into account mechanisms. We also current understanding these infections. Finally, provide insights relatively unexplored partial duplication known dup α7, emerging significant factor scenarios.

Language: Английский

Citations

12
Dihuang Yinzi Improves Scopolamine-Induced Learning and Memory Impairment by Regulating Plasma Exosome-Derived BDNF DOI

Wenna Su,

Yuzhong Du,

Wenting Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119322 - 119322

Published: Jan. 1, 2025

Language: Английский

Citations

0
Integrative single-cell RNA sequencing and mendelian randomization analysis reveal the potential role of synaptic vesicle cycling-related genes in Alzheimer's disease DOI Creative Commons

Junfeng Zeng,

Ruihua Zhang,

Huihua Xu

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100097 - 100097

Published: Feb. 1, 2025

Language: Английский

Citations

0
Sex-Specific Links Between Low Choline, Metabolic Dysfunction, and Neuropathology in Obesity: Insights from Humans and the 3xTg-AD Mouse Model of Alzheimer's disease. DOI Open Access
Wendy Winslow, Jessica M. Judd, Savannah Tallino

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

The growing prevalence of obesity, a risk factor for disorders such as Alzheimer's Disease (AD), raises concerns about the effects on cognitive health. AD currently impacts 6.9 million Americans aged 65 and older is characterized by presence amyloid beta (Aβ) plaques, neurofibrillary tau tangles, neuroinflammation, all which contribute to impairment. Insulin resistance, common in both obesity AD, disrupts brain glucose metabolism accelerates neurodegeneration. Understanding factors that link these conditions could lead new strategies combating disease. Notably, B-like vitamin choline necessary fat has been shown help reduce incidence. However, ∼90% are deficient, decreases this nutrient have associated with decline. Here, we examined circulating levels, inflammation, metabolic dysfunction human participants (BMI > 30) compared normal BMIs (18.5-24.9), well 3xTg-AD mice, an model, fed choline-deficient diet throughout adulthood. Our results revealed obese exhibited significantly lower levels those healthy BMI. Lower correlated higher %Body increased markers insulin resistance. Elevated inflammatory cytokines were also seen mice diet, significant weight gain dysfunction. AD-like pathology was exacerbated deficient mice. These findings underscore relationship between low decline risk. Adequate intake may mitigate potentially preventing diseases. Obesity linked resistance (IR) systemic recognized disease (AD).Women exhibit men, individuals display than BMI.Lower body percentage, IR liver dysfunction, heightened inflammation.3xTg-AD experience considerable gain, pathology, resembling observed participants.

Language: Английский

Citations

0
Unraveling the mystery of citrate transporters in Alzheimer’s disease: An updated review DOI
Anirban Goutam Mukherjee, Shatakshi Mishra, Abilash Valsala Gopalakrishnan

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 107, P. 102726 - 102726

Published: March 11, 2025

Language: Английский

Citations

0
Dietary inflammatory index and brain disorders: a Large Prospective Cohort study DOI Creative Commons

Yan Fu,

Si‐Jia Chen, Zhibo Wang

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 27, 2025

There is emerging evidence that diet plays a key contributor to brain health, however, limited studies focused on the association of dietary inflammatory potential with disorders. This study aimed examine inflammation disorders in UK biobank. The prospective cohort used data from 2006 2010 Biobank, median follow-up duration for different outcomes ranging between 11.37 11.38. Dietary index and Energy-adjusted [DII EDII] were assessed through plausible recalls. Outcomes included (all-cause dementia [ACD], Alzheimer's disease [AD], Parkinson's [PD], stroke, sleep disorder, anxiety depression disorder) magnetic resonance imaging measures. Cox proportional-hazard models, restricted cubic spline model [RCS], Ordinary least squares regressions, structural equation models estimate associations. Of 164,863 participants available recalls, 87,761 (53.2%) female, mean (SD) age was 58.97 (8.05) years, education years 7.49 (2.97) years. Vegetables fresh fruits show significant anti-inflammatory properties, while low-fiber bread animal fats pro-inflammatory properties. nonlinear associations DII EDII scores ACD, AD, anxiety, observed. Multivariable-adjusted HRs highest score VS lowest 1.165 (95% CI 1.038–1.307) 1.172 1.064–1.291) 1.110 1.029–1.197) 1.184 1.111–1.261) 1.136 1.057–1.221) depression. Similar results observed regard score. Compared group, group showed higher risk depression, stroke dementia. Results sensitivity analyses multivariable similar main results. Pro-inflammatory diets associated Our findings suggest means lower

Language: Английский

Citations

0
Platycodon grandiflorum exosome-like nanoparticles: the material basis of fresh platycodon grandiflorum optimality and its mechanism in regulating acute lung injury DOI Creative Commons

FU Jing-min,

Zhuolin Liu,

Zhiying Feng

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 4, 2025

Acute lung injury (ALI) is a severe respiratory disease accompanied by diffuse inflammatory responses induced various clinical causes. Many fresh medicinal plants have shown better efficacy than their dried forms in preventing and treating diseases like inflammation. As classical Chinese herb, platycodon grandiflorum (PG) has been demonstrated effective pneumonia, but most of previous studies focused on the processed or PG formats, while specific benefits its form are still underexplored. Exosome-like nanoparticles derived from expected to point out an important direction for exploring material basis mechanism this herbal medicine. The could effectively improve ALI lipopolysaccharide (LPS), relieve histopathological weight loss, reduce levels factors mice, exhibiting treatment ALI. Further extraction purification exosome-like (PGLNs) that PGLNs had good biocompatibility, with characteristics consistent general nanoparticles. Besides, proteomic analysis indicated were rich variety proteins. Animal experiments showed improved pathological changes LPS-induced tissues, inhibited expression promoted anti-inflammatory factors, exerted regulatory effect polarization macrophages. Cell further confirmed be taken up RAW264.7 cells repolarize M1 macrophages into M2 type, therefore reducing secretion harmful cytokines. Moreover, non-targeted metabolomics reveals inflammation control macrophage manner closely linked pathways including glycolysis lipid metabolism, highlighting potential which protect lungs damage Fresh repair effects form. one active substances PG, may regulate regulating metabolic metabolism glycolysis, so as injury.

Language: Английский

Citations

0
Shared Mechanisms of Blood-Brain Barrier Dysfunction and Neuroinflammation in COVID-19 and Alzheimer’s Disease DOI Creative Commons
Meredith G. Mayer, Tracy Fischer

American Journal Of Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the virus's impact on central nervous system (CNS) and its potential to exacerbate neurodegenerative diseases like Alzheimer's disease (AD). Emerging evidence suggests that SARS-CoV-2 infection contributes chronic neuroinflammation, a key driver in etiopathogenesis of AD. Shared mechanisms, including blood-brain barrier (BBB) dysfunction, systemic inflammation, activation immune pathways, may link AD onset and/or progression, particularly among vulnerable individuals, such as those advanced age. This review explores convergent pathways involving renin-angiotensin-aldosterone (RAAS), Wnt/β-catenin signaling, NFκB activation, interferon (IFN) focusing their roles BBB integrity neuroinflammation. SARS-CoV-2-mediated ACE2 depletion disrupts RAAS homeostasis, favoring proinflammatory signaling parallels vascular dysfunction Dysregulation exacerbates permeability, while IFN contribute breakdown propagate CNS inflammation via endothelial cell activation. These interactions amplify prodromal pathology initiate pathogenesis. By identifying mechanistic overlaps between AD, this underscores need for therapeutic strategies targeting shared dysfunction. Understanding these connections is critical mitigating long-term neurological sequelae reducing burden

Language: Английский

Citations

0