International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 291, P. 138947 - 138947
Published: Dec. 24, 2024
Language: Английский
Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 474 - 474
Published: March 7, 2024
Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types, including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells and, specifically, their pathology treatment.
Language: Английский
Citations
11
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102521 - 102521
Published: Sept. 1, 2024
Language: Английский
Citations
11
Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
9
The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)
Published: Aug. 6, 2024
Abstract Migraine, a primary headache disorder whose mechanism remains incompletely understood, appears to involve the activation of trigeminovascular system (TS) during attacks. Research suggests that inflammatory processes mediated by immune may play role in migraine pathophysiology. Neuroinflammation is often associated with attacks, cytokines serving as crucial mediators process. Elevated levels pro-inflammatory cytokines, such interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), have been observed blood cerebrospinal fluid individuals experiencing These capacity sensitize pain pathways brain, thereby increasing sensitivity stimuli. This phenomenon, known central sensitization, believed contribute intensity persistence pain. Kynurenines, endogenous glutamatergic mechanisms, can significantly influence pathophysiology disorders. The kynurenine collectively pathway (KP), which act on multiple receptors, glutamate aryl hydrocarbon receptors (AhRs), G protein-coupled 35 (GPR35), α-7 nicotinic acetylcholine (α7 nACh) receptors. are also found various cells system, so KP pathomechanism headaches be through them. In this review, our goal show possible link between context inflammation migraine. Migraine research recent years has focused neuropeptides, calcitonin gene-related peptide (CGRP) pituitary adenylate cyclase-activating polypeptide (PACAP) potential pathogenic factors therapeutic approaches. peptides share many similarities their characteristics roles. For instance, they exhibit potent vasodilation, occur both peripheral nervous systems, transmitting nociception neurogenic inflammation. investigation connections aforementioned neuropeptides could significant uncovering identifying new drug candidates.
Language: Английский
Citations
6
Advanced Science, Journal Year: 2024, Volume and Issue: 11(32)
Published: June 25, 2024
Abstract Lack of liver regenerative capacity is the primary cause hepatic failure and even mortality in patients undergoing hepatectomy, with no effective intervention strategies currently available. Therefore, identifying efficacious interventions to enhance regeneration pivotal for optimizing clinical outcomes. Recent studies have demonstrated that vagotomy exerts an inhibitory effect on following partial thereby substantiating role played by vagus nerve process regeneration. In recent years, electroacupuncture (EA) has emerged as a non‐invasive technique stimulating nerve. However, EA remains uncertain. this study, 70% hepatectomy (PH) mouse model utilized investigate effects acute elucidate its underlying molecular mechanisms. It observed at ST36 acutely activated cholinergic neurons dorsal motor nucleus (DMV), resulting increased release acetylcholine from vagal endings subsequent activation IL‐6 signaling macrophages. Ultimately, these events promoted hepatocyte proliferation facilitated These findings provide insights into fundamental brain‐liver axis mechanism through which promotes regeneration, offering novel therapeutic approach post‐hepatectomy disorders.
Language: Английский
Citations
5
Gefässchirurgie, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Citations
0
Cardiovascular Drugs and Therapy, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Language: Английский
Citations
0
Translational Neuroscience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Jan. 1, 2024
Our previous studies have shown that activating α7nAChRs suppresses systemic inflammation and immunity through the cholinergic anti-inflammatory pathway (CAP) in early sepsis. Now medullary visceral zone (MVZ) is center of CAP responsible for regulating inflammation, what changes will occur MVZ's pathology function sepsis, especially when interfering with α7nAChRs? Does activation contribute to inhibition inflammation? To clarify these issues, we explored state by detecting serum levels TNF-α, IL-6, HMGB1, sCD14, CD4
Language: Английский
Citations
0
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 20, 2024
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 267 - 274
Published: Nov. 22, 2024
Language: Английский
Citations
0