Dynamic modeling of neuromodulation techniques: Towards elaboration and individual specificity

EPL (Europhysics Letters), Journal Year: 2024, Volume and Issue: 145(3), P. 32001 - 32001

Published: Jan. 29, 2024

Abstract Neurological disorders place a significant burden on patients, their families, and society, posing immense scientific challenges in terms of treatment mechanistic research. Neuromodulation involves the application invasive or non-invasive technologies to externally manipulate nervous system brain, aiming provide excitatory inhibitory modulation that can improve abnormal neural activity. In previous studies, neurodynamic analysis methods have not only provided novel tools for study neuromodulation techniques, but also new strategies diagnosis neurological diseases. this paper, we present brief overview current state dynamic modeling various including electrical, optical, magnetical, ultrasonic approaches, discuss future prospects developments neuromodulation.

Language: Английский

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A narrative review of non-invasive brain stimulation techniques in neuropsychiatric disorders: current applications and future directions

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, Journal Year: 2024, Volume and Issue: 60(1)

Published: March 30, 2024

Abstract Background Neuropsychiatric disorders significantly burden individuals and society, necessitating the exploration of innovative treatment approaches. Non-invasive brain stimulation techniques have emerged as promising interventions for these disorders, offering potential therapeutic benefits with minimal side effects. This narrative review provides a comprehensive overview non-invasive techniques' current applications future directions in managing neuropsychiatric disorders. Methods A thorough search relevant literature was conducted to identify studies investigating The selected were critically reviewed, their findings synthesised provide state knowledge field. Results highlights including major depressive disorder, Parkinson's disease, schizophrenia, insomnia, cognitive impairments. It presents evidence supporting efficacy modulating activity, alleviating symptoms, enhancing functions. Furthermore, addresses challenges such interindividual variability, optimal target site selection, standardisation protocols. also discusses directions, exploring novel sites, personalised protocols, integrating other modalities, identifying biomarkers response. Conclusion offer avenues Further research is necessary optimise establish standardised guidelines, underscore valuable additions armamentarium treatments.

Language: Английский

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Temporal Interference Stimulation Boosts Working Memory Performance in the Frontoparietal Network

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(3)

Published: Feb. 12, 2025

ABSTRACT Temporal interference (TI) stimulation is a novel neuromodulation technique that overcomes the depth limitations of traditional transcranial electrical while avoiding invasiveness deep brain stimulation. Our previous behavioral research has demonstrated effects multi‐target TI in enhancing working memory (WM) performance, however, neural mechanisms this special form envelope modulation remain unclear. To address issue, here we designed randomized, double‐blind, crossover study, which consisted task‐based functional magnetic resonance imaging (fMRI) experiment, to explore how offline modulated activity and performance healthy adults. We conducted 2 × within‐subjects design with two factors: (TI vs. Sham) time (pre post). Participants received protocols random order: (beat frequency: 6 Hz, targeting middle frontal gyrus [MFG] inferior parietal lobule [IPL]) sham Neuroimaging data WM task different cognitive loads were acquisited immediately before after found significantly improved d ′ high‐demand task. Whole‐brain analysis showed significant time‐by‐stimulation interactions main clusters IPL precuneus lower activation The generalized psychophysiological interaction (gPPI) revealed task‐modulated connectivity between MFG IPL, improvement observed Notably, increasing induced by was positively correlated better performance. Overall, our findings show specific on frontoparietal network may contribute provide new perspectives for future applications.

Language: Английский

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An Update on the Use of Neuromodulation Strategies in the Treatment of Schizophrenia

American Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 182(4), P. 332 - 340

Published: April 1, 2025

The field of neuromodulation has evolved tremendously and now includes a vast array interventions utilizing different technologies that span electrical, magnetic, ultrasound forms stimulation. evolution holds the promise fewer adverse effects noninvasive approach, increasing scale at which these may be offered in hospital community settings. While majority studies have focused on patients with mood disorders, predominantly depression, there is an unmet need for schizophrenia, who are dire novel therapeutic options. Advances neuroimaging approaches examining individual variability transdiagnostic symptoms lead to more effective treatments this patient population. This overview explores modern landscape invasive schizophrenia. It begins involve diffuse stimulation cortex subcortex then reviews focal cortical subcortical levels. authors also reflect relationship between our understanding neurobiology schizophrenia interventions.

Language: Английский

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Boosting psychological change: Combining non-invasive brain stimulation with psychotherapy

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 142, P. 104867 - 104867

Published: Sept. 16, 2022

Language: Английский

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Comparing different non-invasive brain stimulation interventions for bipolar depression treatment: A network meta-analysis of randomized controlled trials

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 156, P. 105483 - 105483

Published: Dec. 6, 2023

Non-invasive brain stimulation (NIBS) is a promising treatment for bipolar depression. We systematically searched randomized controlled trials on NIBS treating depression (INPLASY No: 202340019). Eighteen articles (N = 617) were eligible network meta-analysis. Effect sizes reported as standardized mean differences (SMDs) or odds ratios (ORs) with 95% confidence intervals (CIs). Anodal transcranial direct current over F3 plus cathodal F4 (a-tDCS-F3 +c-tDCS-F4; SMD -1.18, 95%CIs -1.66 to -0.69, N 77), high-definition tDCS (HD-tDCS-F3; -1.17, -2.00 -0.35, 25), high frequency deep magnetic (HF-dTMS; -0.81, -1.62 -0.001, and repetitive TMS low (HF-rTMS-F3 +LF-rTMS-F4; -0.77, -1.43 -0.11, 38) significantly improved depressive symptoms compared sham controls. Only a-tDCS-F3 +c-tDCS-F4 (OR 4.53, 1.51-13.65) HF-rTMS-F3 +LF-rTMS-F4 (4.69, 1.02-21.56) showed higher response rates. No active interventions exhibited significant in dropout side effect rates,

Language: Английский

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The effect of transcranial alternating current stimulation on functional recovery in patients with stroke: a narrative review

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 10, 2024

Stroke is a common neurological disorder worldwide that can cause significant disabilities. Transcranial alternating current stimulation (tACS) an emerging non-invasive neuromodulation technique regulates brain oscillations and reshapes rhythms. This study aimed to investigate the effect of tACS on functional recovery in patients with stroke. The MEDLINE (PubMed), Cochrane Library, Embase, SCOPUS, Web Science databases were searched for English-language articles stroke, published up October 20, 2023. following key search phrases combined identify potentially relevant articles: 'tACS,' 'transcranial stimulation,' 'stroke,' 'cerebral infarct,' 'intracerebral hemorrhage.' inclusion criteria selection as follows: (1) studies involving stroke (2) used recovery. A total 34 identified. Five included this review after reading titles abstracts assessing their eligibility based full-text articles. Among studies, one investigated improvement overall status tACS, two motor function gait patterns. Moreover, reported efficacy aphasia recovery, evaluated hemispatial neglect. Our findings suggest improves application was associated improved sensorimotor impairment, aphasia, potential clinical should be supported by high-quality, evidence-based studies.

Language: Английский

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Exploring the Prospects of Transcranial Electrical Stimulation (tES) as a Therapeutic Intervention for Post-Stroke Motor Recovery: A Narrative Review

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 322 - 322

Published: March 27, 2024

Introduction: Stroke survivors often have motor impairments and related functional deficits. Transcranial Electrical Stimulation (tES) is a rapidly evolving field that offers wide range of capabilities for modulating brain function, it safe inexpensive. It has the potential widespread use post-stroke recovery. Direct Current (tDCS), Alternating (tACS), Random Noise (tRNS) are three recognized tES techniques gained substantial attention in recent years but different mechanisms action. tDCS been widely used stroke rehabilitation, while applications tACS tRNS very limited. The protocols could vary significantly, outcomes heterogeneous. Purpose: current review attempted to explore underlying commonly employed evaluate their prospective advantages challenges recovery after stroke. Conclusion: depolarize hyperpolarize potentials cortical neurons, target specific rhythms entrain neural networks. Despite extensive tDCS, complexity networks calls more sophisticated modifications like tRNS.

Language: Английский

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Transcranial pulsed current stimulation: A scoping review of the current literature on scope, nature, underlying mechanisms, and gaps

Psychophysiology, Journal Year: 2024, Volume and Issue: 61(3)

Published: Jan. 10, 2024

Transcranial pulsed current stimulation (tPCS) is a noninvasive brain technique that has aroused considerable attention in recent years. This review aims to provide an overview of the existing literature on tPCS, examine scope and nature previous research, investigate its underlying mechanisms, identify gaps literature. Searching online databases resulted 36 published tPCS studies from inception until May 2023. These were categorized into three groups: human healthy individuals, clinical conditions, animal studies. The findings suggest potential modulate excitability by entraining neural oscillations utilizing stochastic resonance. However, mechanisms are not yet fully understood require further investigation. Furthermore, included indicate may have therapeutic for neurological diseases. before can be applied settings, better understanding crucial. Hence, four types research: basic, strategic, applied, experimental gaps. Analysis these categories revealed with diverse parameters, effects, presents wide range research opportunities future investigations.

Language: Английский

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Transcranial alternating current stimulation for schizophrenia: a systematic review of randomized controlled studies

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

Background In randomized clinical trials (RCTs) investigating the application of transcranial alternating current stimulation (tACS) in schizophrenia, inconsistent results have been reported. The purpose this exploratory systematic review RCTs was to evaluate tACS as an adjunct treatment for patients with schizophrenia based on its therapeutic effects, tolerability, and safety. Methods Our analysis included that evaluated adjunctive tACS’ effectiveness, safety patients. Three independent authors extracted data synthesized it using RevMan 5.3 software. Results involving 76 were encompassed analysis, 40 participants receiving active 36 sham tACS. study revealed a significant superiority over improving total psychopathology (standardized mean difference [SMD] = −0.61, 95% confidence interval [CI]: −1.12, −0.10; I 2 16%, p 0.02) negative (SMD −0.65, CI: −1.11, −0.18; 0%, 0.007) schizophrenia. two groups, however, showed no differences positive psychopathology, general or auditory hallucinations (all > 0.05). Two examined neurocognitive effects tACS, yielding varied findings. Both groups demonstrated similar rates discontinuation due any reason adverse events Conclusion Adjunctive is promising viable approach mitigating individuals diagnosed However, gain more comprehensive understanding tACS’s imperative conduct extensive, meticulously planned, well-documented RCTs.

Language: Английский

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