JURNAL INFO KESEHATAN,
Journal Year:
2023,
Volume and Issue:
21(2), P. 341 - 349
Published: June 30, 2023
Along
with
the
spread
of
COVID-19
pandemic,
there
has
been
an
increase
in
reports
confirmed
cases
pregnant
women
COVID-19.
Exposure
to
virus
pregnancy
can
affect
fetus
and
result
long-term
vulnerability
abnormalities
child's
brain
development.
This
study
aimed
determine
impact
prenatal
Covid-19
on
development
toddlers.
The
research
method
uses
observational
cross-sectional
analysis.
Secondary
data
mothers
were
obtained
from
Prof.
RD
Kandou
General
Hospital,
Wolter
Monginsidi
Manado
Adventist
Hospital.
Primary
toddler
using
KPSP
Development
Questionnaire
instrument
10
Community
Health
Centers
City
a
total
92
respondents
for
two,
46
born
during
period
toddlers
who
not
have
period.
results
showed
that
was
no
significant
effect
p-value
0.562
impaired
gross
motor,
fine
socialization,
independence,
speech,
language
Based
it
be
concluded
both
are
at
risk
experiencing
growth
disturbances,
especially
pandemic
because
could
effects
occur
infants
exposed
prenatal/intrauterine
Journal of Neuroinflammation,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: June 25, 2024
Abstract
Background
The
SARS-CoV-2
virus
activates
maternal
and
placental
immune
responses.
Such
activation
in
the
setting
of
other
infections
during
pregnancy
is
known
to
impact
fetal
brain
development.
effects
on
neurodevelopment
are
mediated
at
least
part
by
microglia.
However,
microglia
inaccessible
for
direct
analysis,
there
no
validated
non-invasive
surrogate
models
evaluate
utero
microglial
priming
function.
We
have
previously
demonstrated
shared
transcriptional
programs
between
Hofbauer
cells
(HBCs,
or
macrophages)
mouse
models.
Methods
results
assessed
HBCs
isolated
from
24
term
placentas
(
N
=
10
positive
cases,
14
negative
controls).
Using
single-cell
RNA-sequencing,
we
that
HBC
subpopulations
exhibit
distinct
cellular
programs,
with
specific
differentially
impacted
SARS-CoV-2.
Assessment
expressed
genes
implied
impaired
phagocytosis,
a
key
function
both
microglia,
some
subclusters.
Leveraging
synaptic
pruning,
showed
pregnancies
can
be
transdifferentiated
into
microglia-like
(HBC-iMGs),
pruning
behavior
compared
controls.
Conclusion
These
findings
suggest
birth
used
create
personalized
offspring
programming.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1201 - 1201
Published: Jan. 30, 2025
The
COVID-19
pandemic
has
raised
significant
concerns
regarding
its
potential
impact
on
maternal
and
neonatal
health.
This
study
aimed
to
investigate
the
immunologic
hemostatic
profiles
of
neonates
exposed
SARS-CoV-2
during
peripartum
period
(0–14
days
prior
delivery).
retrospective
included
28
born
COVID-19-positive
mothers
a
control
group
54
who
never
tested
positive
for
pregnancy.
Arterial
blood
samples
were
collected
from
all
second
day
life
simultaneous
assessment
full
count,
C-reactive
protein
(CRP),
serum
interleukin-6
(IL-6),
Interferon
gamma-induced
10
(IP-10)
levels,
as
well
Rotational
Thromboelastometry
(ROTEM)
tests
(EXTEM,
INTEM,
NATEM).
Neonates
those
COVID-19-negative
exhibited
similar
coagulation
based
ROTEM
analysis.
Multiple
linear
regression
analysis
revealed
that
infection
was
associated
with
higher
IP-10
levels
in
(coefficient:
+16.8,
95%
CI:
+9.0
+24.6,
p
<
0.0001).
Our
findings
suggest
presence
disturbance
is
related
recent
exposure
infection,
evidenced
by
increased
obtained
SARS-CoV-2-positive
mothers.
However,
did
not
appear
disrupt
profile
newborns
test
results.
The Lancet Child & Adolescent Health,
Journal Year:
2025,
Volume and Issue:
9(3), P. 162 - 171
Published: Feb. 18, 2025
Understanding
the
effects
of
SARS-CoV-2
infection
and
COVID-19
vaccination
during
pregnancy
can
help
inform
clinical
guidance
tackle
vaccine
hesitancy.
We
examined
relationships
between
pregnancy,
early
child
developmental
concerns
in
children
aged
13-15
months
Scotland.
created
a
large,
population-level
linked
administrative
health
dataset,
combining
Pregnancy
Scotland
(COPS)
dataset
with
age
month
review
data
other
datasets.
included
estimated
to
have
been
conceived
after
May
18,
2020,
born
before
Sept
30,
2021,
their
mothers.
used
logistic
regression
modelling
investigate
associations
(ie,
parent
or
caregiver
visitor-identified
regarding
speech-language-communication,
problem
solving,
gross
motor,
personal-social,
emotional-behavioural
development)
measured
routine
reviews
at
months,
including
adjustment
for
confounders
covariates.
A
total
24
919
child-mother
pairs
(12
752
[51·2%]
male
children;
12
167
[48·8%]
female
children)
were
included.
1631
(6·5%)
prenatally
exposed
4943
(19·8%)
vaccination.
found
no
concerns.
After
confounder
covariate
adjustment,
was
associated
reduced
odds
solving
(odds
ratio
0·78
[95%
CI
0·64-0·95]),
personal-social
(0·76
[0·61-0·95]),
(0·67
[0·48-0·92])
development,
but
had
infections
do
not
appear
be
childhood
concerns,
vaccinations
safe
from
perspective
As
some
become
apparent
until
are
older
than
future
research
should
continue
monitor
outcomes
as
grow
develop.
Economic
Social
Research
Council.
Audiology - Communication Research,
Journal Year:
2025,
Volume and Issue:
30
Published: Jan. 1, 2025
ABSTRACT
Purpose
To
investigate
the
risk
of
child
development
in
18-month-old
children
born
to
mothers
who
were
infected
by
SARS-CoV-2
virus
during
pregnancy
and
identify
possible
delays
indicators.
Methods
Children
between
January
2021
August
2021,
whose
tested
positive
for
COVID-19
pregnancy,
participated
research.
linguistic,
motor,
cognitive
social
development,
Ages
&
Stages
Questionnaires
(ASQ-3)
was
used
five
domains:
Communication,
Gross
motor
coordination,
Fine
Problem
solving
Personal/social.
Data
described
using
absolute
percentage
frequencies
mean,
standard
deviation,
minimum,
median
maximum.
analyze
association
variables
interest,
Poisson
regression
model
used.
Tukey's
post-test
multiple
comparisons.
Results
The
Personal-Social
domains,
followed
coordination
Solving
best
performing.
worst
performance
observed
Communication
domain,
coordination.
Prematurity,
birth
weight,
Apgar
score
need
hospitalization
after
associated
with
low
domains
assessed.
Conclusion
A
developmental
delay
pregnancy.
domain
greatest
loss
changes
Motor
Coordination.
Audiology - Communication Research,
Journal Year:
2025,
Volume and Issue:
30
Published: Jan. 1, 2025
RESUMO
Objetivo
Investigar
risco
de
alterações
no
desenvolvimento
infantil
crianças
18
meses
nascidas
mães
que
foram
infectadas
pelo
vírus
SARS-CoV-2
durante
a
gestação
e
identificar
possíveis
atrasos
em
indicadores
desenvolvimento.
Métodos
Participaram
da
pesquisa
41
nasceram
período
janeiro
2021
agosto
2021,
cujas
testaram
positivo
para
Covid-19
gestação.
Para
investigação
do
linguístico,
motor,
cognitivo
social
foi
utilizado
o
Ages
&
Stages
Questionnaires
nos
cinco
domínios:
Comunicação,
Coordenação
Motora
Ampla,
Fina,
Resolução
Problemas
Pessoal/Social.
Os
dados
descritos
por
meio
frequências
absolutas
percentuais
média,
desvio
padrão,
mínimo,
mediana
máximo.
analisar
associação
entre
as
variáveis
interesse
modelo
regressão
Poisson.
O
pós-teste
Tukey
comparações
múltiplas.
Resultados
domínios
Pessoal/-Social,
Fina
Problemas,
neste
seguimento,
os
melhor
desempenho.
pior
desempenho
observado
domínio
seguido
Ampla.
A
prematuridade,
peso
ao
nascimento,
índice
Apgar
necessidade
internação
criança
pós-nascimento
associadas
baixo
avaliados.
Conclusão
Foi
atraso
contaminadas
com
maior
prejuízo
alteração
BMC Pregnancy and Childbirth,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 26, 2025
In
recent
years,
severe
acute
respiratory
syndrome
corona
virus
2
(SARS-CoV-2)
infection
has
been
prevalent
worldwide.
Pregnant
women
belong
to
a
special
group,
and
it
is
very
important
for
clinicians
pay
attention
the
impact
of
SARS-CoV-2
on
pregnancy
outcomes.
However,
there
are
limited
studies
outcomes
during
first
trimester.
To
investigate
effect
in
trimester
Clinical
information
pregnant
whose
last
menstrual
period
was
between
October
1,
2022,
April
2023,
who
were
registered
Obstetrics
Gynecology
department
Peking
University
International
Hospital,
analyzed.
Among
them,
498
with
included
study
group;
while
total
654
no
control
group.
Mann
Whitney
U
test,
χ2
Fisher's
exact
probability
method,
multivariate
logistic
regression
used
analyze
A
30
cases
group
experienced
loss
before
28
weeks
gestation,
468
delivered.
41
613
The
rates
two
groups
6.02%
6.27%,
respectively,
statistically
significant
difference
(P
>
0.05).
There
0.05)
baseline
data
(delivery
age,
pre-pregnancy
body
mass
index,
gestational
parity)
groups.
neonatal
malformation,
premature
birth,
rupture
membranes,
postpartum
hemorrhage,
cesarean
section,
small
age
infants,
low
birth
weight
macrosomia,
asphyxia
compared,
incidence
hypertension
significantly
higher
than
that
=
0.012).
this
single
center
study,
we
found
may
increase
risk
hypertension,
incidences
other
adverse
such
as
did
not
compared
without
Frontiers in Pediatrics,
Journal Year:
2023,
Volume and Issue:
11
Published: Oct. 17, 2023
Background
The
COVID-19
pandemic
has
affected
a
significant
number
of
pregnant
women
worldwide,
but
studies
on
immune
responses
have
presented
conflicting
results.
This
study
aims
to
systematically
review
cytokine
profiles
in
with
SARS-CoV-2
infection
and
their
infants
evaluate
potential
transplacental
transfer
cytokines.
Materials
methods
A
comprehensive
search
4
databases
was
conducted
identify
relevant
studies.
Inclusion
criteria
included
measuring
individual
cytokines
and/or
neonates.
Studies
were
evaluated
for
quality,
data
extracted
analysis.
Meta-analyses
performed
using
the
random-effects
model.
Results
Seventeen
met
inclusion
criteria,
including
from
748
287
infants.
More
than
three
these
20
maternal
serum,
10
available
cord
blood
samples.
Only
serum
level
CXCL10
significantly
up-regulated
positive
(
n
=
339)
compared
negative
409).
Subset
analysis
samples
183)
collected
during
acute
phase
showed
elevated
IFN-γ.
No
differences
levels
found
between
born
mothers
97)
without
190)
gestation.
limited
by
insufficient
data.
heterogeneity
among
substantial.
Conclusion
findings
suggest
that
pregnancy
are
not
dysregulated,
except
IFN-γ
illness.
evidence
increased
observed,
although
this
could
be
impacted
time
period
initial
collection.
These
results
provide
some
reassurance
parents
healthcare
providers
should
interpreted
cautiously
due
variations
limitations.
