Cannabidiol (CBD) in Cancer Management

Cancers, Journal Year: 2022, Volume and Issue: 14(4), P. 885 - 885

Published: Feb. 10, 2022

The plant Cannabis sativa has been in use medicinally for several thousand years. It over 540 metabolites thought to be responsible its therapeutic effects. Two of the key phytocannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). Unlike THC, CBD does not have potentially intoxicating Preclinical clinical research indicates that a wide range effects, many them relevant management cancer. In this article, we explore some potential mechanisms action cancer, evidence efficacy integrative cancer including side effects associated with treatment, demonstrating integration orthodox care.

Language: Английский

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Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2630 - 2630

Published: Sept. 25, 2023

Historically, cannabis has been valued for its pain-relieving, anti-inflammatory, and calming properties. Ancient civilizations like the Egyptians, Greeks, Chinese medicines recognized their therapeutic potential. The discovery of endocannabinoid system, which interacts with phytoconstituents, scientifically explained how affects human immune including central nervous system (CNS). This review explores evolving world cannabis-based treatments, spotlighting diverse applications. By researching current research clinical studies, we probe into cannabinoids Δ9-tetrahydrocannabinol (THC) cannabidiol (CBD) help to manage conditions ranging from chronic pain, persistent inflammation, cancer, inflammatory bowel disease, neurological disorders even viral diseases such as Human Immunodeficiency virus (HIV), SARS-CoV-2. emerging monkeypox. long-term recreational use can develop disorder (CUD), therefore, understanding factors contributing development maintenance addiction, genetic predisposition, neurobiological mechanisms, environmental influences, will be timely. Shedding light on adverse impacts CUD underscores importance early intervention, effective treatment approaches, public health initiatives address this complex issue in an landscape policies perceptions.

Language: Английский

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Inflammation and cancer: friend or foe?

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Chronic inflammation plays a crucial role in the onset and progression of pathologies like neurodegenerative cardiovascular diseases, diabetes, cancer, since tumor development chronic are linked, sharing common signaling pathways. At least 20% breast colorectal cancers associated with triggered by infections, irritants, or autoimmune diseases. Obesity, inflammation, cancer interconnection underscore importance population-based interventions maintaining healthy body weight, to disrupt this axis. Given that dietary inflammatory index is correlated an increased risk adopting anti-inflammatory diet supplemented nutraceuticals may be useful for prevention. Natural products their derivatives offer promising antitumor activity favorable adverse effect profiles; however, natural bioactive drugs challenging due variability complexity, requiring rigorous research processes. It has been shown combining products, such as non-steroidal (NSAIDs), corticosteroids, statins, plant-derived demonstrate clinical utility accessible adjuvants traditional therapeutic approaches, known safety profiles. Pharmacological approaches targeting multiple proteins involved pathogenesis emerge particularly option. systemic multifactorial nature comprehensive strategies essential long term success therapy. To gain insights into carcinogenic phenomena discover diagnostic clinically relevant biomarkers, pivotal understand genetic variability, environmental exposure, habits, TME composition, establish based on molecular analysis. Furthermore, use endocannabinoid, cannabinoid, prostamide-type compounds potential targets biomarkers requires further investigation. This review aims elucidate specific etiological agents mediators contributing persistent reactions development. explores treatment, emphasizing urgent need cost-effective address cancer-associated inflammation.

Language: Английский

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Use of Cannabis and Cannabinoids for Treatment of Cancer

Cancers, Journal Year: 2022, Volume and Issue: 14(20), P. 5142 - 5142

Published: Oct. 20, 2022

The endocannabinoid system (ECS) is an ancient homeostasis mechanism operating from embryonic stages to adulthood. It controls the growth and development of many cells cell lineages. Dysregulation components ECS may result in uncontrolled proliferation, adhesion, invasion, inhibition apoptosis increased vascularization, leading various malignancies. Cancer disease division. In this review, we will discuss whether changes are a cause or consequence malignization different tissues react differently ECS. We potential use cannabinoids for treatment cancer, focusing on primary outcome/care—tumor shrinkage eradication, as well secondary outcome/palliative care—improvement life quality, including pain, appetite, sleep, more factors. Finally, complete review with chapter sex- gender-specific differences response cannabinoids, equality access treatments cannabinoids.

Language: Английский

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Biopolymeric nanoparticles based effective delivery of bioactive compounds toward the sustainable development of anticancerous therapeutics

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: July 15, 2022

Nowadays, effective cancer therapy is a global concern, and recent advances in nanomedicine are crucial. Cancer one of the major fatal diseases leading cause death globally. Nanotechnology provides rapidly evolving delivery systems science for treating site-specific manner using natural bioactive compounds, which gaining widespread attention. combined with bioactives very appealing relatively new area treatment. Natural compounds have potential to be employed as chemotherapeutic agent treatment cancer, addition their nutritional benefits. Alginate, pullulan, cellulose, polylactic acid, chitosan, other biopolymers been effectively used therapeutics specific site. Because biodegradability, biopolymeric nanoparticles (BNPs) received lot attention development anticancer drug systems. Biopolymer-based nanoparticle can made variety ways. These developed cost-effective environmentally friendly solution boost efficacy. Effective improved availability, increased selectivity, lower toxicity needed. Recent research findings current knowledge on use BNPs administration chemicals summarized this review.

Language: Английский

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Dysgeusia in Patients with Breast Cancer Treated with Chemotherapy—A Narrative Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(1), P. 226 - 226

Published: Jan. 1, 2023

Breast cancer (BC) is the most common worldwide. Chemotherapy (CT) essential for treatment of BC, but often accompanied by several side effects, including taste alterations, due to different mechanisms. Although dysgeusia usually underestimated clinicians, it considered very worrying and disturbing patients undergoing CT, because induces changes in dietary choices social habits, affecting their physical psychological health, with a profound impact on quality life. Several strategies therapies have been proposed prevent or alleviate CT-induced dysgeusia. This review aimed evaluate available evidence prevalence, pathophysiological mechanisms, clinical consequences, managing BC receiving CT. We queried National Library Medicine, Cochrane Library, Excerpta Medica dataBASE, Cumulative Index Nursing Allied Health Literature database, performing search strategy using database-specific keywords. found that literature this topic scarce, methodologically limited, highly heterogeneous terms study design criteria patient inclusion, making difficult obtain definitive results make recommendations practice.

Language: Английский

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Therapeutic potential of TRPM8 channels in cancer treatment

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 22, 2023

Cancer is a multifactorial process associated with changes in signaling pathways leading to cell cycle variations and gene expression. The transient receptor potential melastatin 8 (TRPM8) channel non-selective cation expressed neuronal non-neuronal tissues, where it involved several processes, including thermosensation, differentiation, migration. Interestingly, has been shown that TRPM8 channels also participate physiological processes related cancer, such as proliferation, survival, invasion. For instance, have an important role the diagnosis, prognosis, treatment of prostate cancer. In addition, reported are progress pancreatic, breast, bladder, colon, gastric, skin cancers, glioblastoma, neuroblastoma. this review, we summarize current knowledge on cancer progression. We discuss therapeutic carcinogenesis, which proposed molecular target for therapy.

Language: Английский

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Potential, Limitations and Risks of Cannabis-Derived Products in Cancer Treatment

Cancers, Journal Year: 2023, Volume and Issue: 15(7), P. 2119 - 2119

Published: April 1, 2023

The application of cannabis products in oncology receives interest, especially from patients. Despite the plethora research data available, added value curative or palliative cancer care and possible risks involved are insufficiently proven therefore a matter debate. We aim to give recommendation on position clinical by assessing recent literature. Various types products, characteristics, quality pharmacology discussed. Standardisation is essential for reliable reproducible quality. oromucosal/sublingual route administration preferred over inhalation drinking tea. Cannabinoids may inhibit efflux transporters drug-metabolising enzymes, possibly inducing pharmacokinetic interactions with anticancer drugs being substrates these proteins. This enhance cytostatic effect and/or drug-related adverse effects. Reversely, it enable dose reduction. Similar likely used symptom management treating pain, nausea, vomiting anorexia. Cannabis usually well tolerated improve life patients (although not unambiguously proven). combination immunotherapy seems undesirable because immunosuppressive action cannabinoids. Further warranted scientifically support (refraining from) using cancer.

Language: Английский

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The Use of Compounds Derived from Cannabis sativa in the Treatment of Epilepsy, Painful Conditions, and Neuropsychiatric and Neurodegenerative Disorders

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5749 - 5749

Published: May 25, 2024

Neurological disorders present a wide range of symptoms and challenges in diagnosis treatment. Cannabis sativa, with its diverse chemical composition, offers potential therapeutic benefits due to anticonvulsive, analgesic, anti-inflammatory, neuroprotective properties. Beyond cannabinoids, cannabis contains terpenes polyphenols, which synergistically enhance pharmacological effects. Various administration routes, including vaporization, oral ingestion, sublingual, rectal, provide flexibility treatment delivery. This review shows the efficacy managing neurological such as epilepsy, neurodegenerative diseases, neurodevelopmental disorders, psychiatric painful pathologies. Drawing from surveys, patient studies, clinical trials, it highlights alleviating symptoms, slowing disease progression, improving overall quality life for patients. Understanding mechanisms can open up possibilities using this plant individual needs.

Language: Английский

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Cannabinoids as Immune System Modulators: Cannabidiol Potential Therapeutic Approaches and Limitations

Cannabis and Cannabinoid Research, Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 22, 2022

Introduction: Cannabidiol (CBD) is the second most abundant Phytocannabinoid in Cannabis extracts. CBD has a binding affinity for several cannabinoid and cannabinoid-associated receptors. Epidiolex (oral solution) been lately licensed by Food Drug Administration (FDA) treatment of pediatric epileptic seizures. Methods: In this review, we discussed promising applications chronic inflammatory conditions, namely CBD's anti-inflammatory effects during bowel disease, coronavirus disease (antiviral effect), brain pathologies (neuroprotective properties), as well immunomodulatory antitumoral activities tumor microenvironment. Special focus was shed on main therapeutic mechanisms action CBD, particularly control immune system endocannabinoid system. Results: Findings suggest that potent drug it manifested immunosuppressive properties context sterile inflammation (e.g., rheumatoid arthritis, neurodegenerative diseases), immunoprotective viral infections (e.g. COVID-19) Similarly, exhibited selective response toward cancer types engaging different targets signaling pathways. These results are favor primary function which homeostatic maintenance. Conclusion: The presented evidence suggests prominent target autoimmune diseases, infections, neurological psychological pathologies, cancer. Moreover, have suggested to be potentially used combination with chemo- or immunotherapy However, clinical still lacking, raises challenge apply translational cannabis research human

Language: Английский

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