Plants,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1704 - 1704
Published: June 19, 2024
Cannabis
contains
numerous
natural
components
and
has
several
effects
such
as
anticancer,
anti-inflammatory
antioxidant.
Cheungsam
is
a
variety
of
non-drug-type
hemp,
developed
in
Korea
used
for
fiber
(stem)
oil
(seed).
The
efficacy
on
skin
not
yet
known,
although
there
are
previous
studies
seed
oil,
no
husk.
In
this
study,
we
investigated
the
potential
husk
ethanol
extract
(CSSH)
to
alleviate
inflammation
through
evaluating
gene
protein
expression
levels
inflammatory
mediators.
results
showed
that
CSSH
reduced
pro-inflammatory
cytokines
(IL-1β,
IL-6,
IL-8,
MCP-1
CXCL10)
atopic
dermatitis-related
(IL-4,
CCL17,
MDC
RANTES)
TNF-α/IFN-γ-induced
HaCaT
cells.
Furthermore,
ERK,
JNK
p38
phosphorylation
were
decreased
p-p65,
p-IκBα,
NLRP3,
caspase-1,
p-JAK1
p-STAT6
suppressed
after
treatment.
significantly
increased
level
barrier
factors
filaggrin
involucrin.
These
suggest
regulates
mechanism
can
be
new
treatment
diseases.
Cells,
Journal Year:
2024,
Volume and Issue:
13(2), P. 187 - 187
Published: Jan. 18, 2024
Cannabis
sativa
is
a
well-known
plant
for
its
psychoactive
effects;
however,
many
derivatives,
such
as
Cannabidiol
(CBD),
contain
several
therapeutic
applications.
Tetrahydrocannabinol
(THC)
the
main
cannabis
derivative
responsible
properties,
while
CBD
non-psychotropic.
For
this
reason,
has
been
more
exploited
in
last
decade.
connected
to
multiple
anticancer
and
when
combined
with
photodynamic
therapy
(PDT),
it
possible
eradicate
tumors
effectively.
In
study,
was
utilized
treat
MCF-7
breast
cancer
cells,
followed
by
vitro
PDT
combination
therapy.
Conventional
treatment
modalities
chemotherapy,
radiotherapy,
etc.
have
reported
inducing
number
of
undesirable
side
effects,
recurrence
disease,
low
quality
life.
cells
were
exposed
varying
concentrations
(i.e.,
1.25,
2.5,
5,
10,
20
μg/mL)
incubated
12
24
h
after
treatment.
The
optimal
doses
then
used
Morphology
biochemical
assays,
including
lactate
dehydrogenase
(LDH)
membrane
integrity,
adenosine
triphosphate
(ATP)
viability,
trypan
blue
exclusion
assay
examine
cellular
responses
treatments.
concentration
Hypericin-Gold
nanoparticles
mediated
combination.
results
revealed
that,
dose-dependent
manner,
conventional
morphological
characteristics
cell
death,
vacuolization,
blebbing,
floating
observed
treated
cells.
demonstrated
an
increase
LDH,
decrease
ATP,
reduction
viability.
This
study
that
induces
death
cultured
vitro.
immunofluorescence
indicated
occurred
via
apoptosis.
conclusion,
proposes
effective
killing
induction
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5659 - 5659
Published: May 23, 2024
Cannabinoids,
the
bioactive
compounds
found
in
Cannabis
sativa,
have
been
used
for
medicinal
purposes
centuries,
with
early
discoveries
dating
back
to
BC
era
(BCE).
However,
increased
recreational
use
of
cannabis
has
led
a
negative
perception
its
and
food
applications,
resulting
legal
restrictions
many
regions
worldwide.
Recently,
cannabinoids,
notably
Δ9-tetrahydrocannabinol
(THC)
cannabidiol
(CBD),
gained
renewed
interest
medical
field
due
their
anti-cancer
properties.
These
properties
include
inhibition
tumour
growth
cell
invasion,
anti-inflammatory
effects,
induction
autophagy
apoptosis.
As
result,
cannabinoids
treat
chemotherapy-associated
side
like
nausea,
vomiting,
pain,
increased,
there
suggestions
implement
large-scale
cancer
therapy.
these
compounds’
cellular
molecular
mechanisms
action
still
need
be
fully
understood.
This
review
explores
recent
evidence
CBD’s
efficacy
as
an
agent,
which
is
non-psychoactive
The
current
will
also
provide
understanding
common
different
cancers.
Studies
shown
that
activity
can
receptor-dependent
(CB1,
CB2,
TRPV,
PPARs)
or
receptor-independent
induced
through
mechanisms,
such
ceramide
biosynthesis,
ER
stress,
subsequent
It
projected
form
basis
therapeutic
applications
CBD.
Therefore,
it
essential
understand
developing
optimizing
pre-clinical
CBD-based
therapies.
Global Sustainability Research,
Journal Year:
2023,
Volume and Issue:
2(4), P. 1 - 29
Published: Oct. 2, 2023
The
Cannabis
plant
(Cannabis
sativa
L.),
also
known
as
hemp,
is
a
sustainable
and
multipurpose
that
may
be
used
for
wide
range
of
purposes,
from
the
fiber
in
its
stalks
to
food
seeds
oil
flowers
seeds.
Since
has
been
recognized
an
outstanding
carbon
trap
environmentally
friendly
biofuel
supports
all
three
aspects
sustainability—the
economy,
environment,
society—it
provide
solution
climate
change
dilemma.
cultivation
practiced
dietary
staple
numerous
places
across
globe
extended
period.
However,
production
prohibited
several
countries
mostly
owing
relationship
with
illicit
drug
consumption.
illegality
impeded
research
efforts
period
time
on
global
scale.
As
result,
people's
ability
assess
whole
beneficial
effects
dangers
shrank.
trend
toward
legalization
decriminalization
accelerated
recent
years.
This
stimulated
more
investigation
into
botanical,
ecological,
practical
plant.
study
reviewed
available
literature
understand
about
plant's
sustainability.
results
demonstrated
potential
plants
affect
product
sustainability
use
hemp
renewable
raw
material.
Furthermore,
this
review
outlines
connections
between
Sustainable
Development
Goals
(SDGs)
United
Nations.
fills
gap
our
understanding
highly
promising
multi-purpose
crop
future.
Cannabis and Cannabinoid Research,
Journal Year:
2022,
Volume and Issue:
unknown
Published: Nov. 22, 2022
Introduction:
Cannabidiol
(CBD)
is
the
second
most
abundant
Phytocannabinoid
in
Cannabis
extracts.
CBD
has
a
binding
affinity
for
several
cannabinoid
and
cannabinoid-associated
receptors.
Epidiolex
(oral
solution)
been
lately
licensed
by
Food
Drug
Administration
(FDA)
treatment
of
pediatric
epileptic
seizures.
Methods:
In
this
review,
we
discussed
promising
applications
chronic
inflammatory
conditions,
namely
CBD's
anti-inflammatory
effects
during
bowel
disease,
coronavirus
disease
(antiviral
effect),
brain
pathologies
(neuroprotective
properties),
as
well
immunomodulatory
antitumoral
activities
tumor
microenvironment.
Special
focus
was
shed
on
main
therapeutic
mechanisms
action
CBD,
particularly
control
immune
system
endocannabinoid
system.
Results:
Findings
suggest
that
potent
drug
it
manifested
immunosuppressive
properties
context
sterile
inflammation
(e.g.,
rheumatoid
arthritis,
neurodegenerative
diseases),
immunoprotective
viral
infections
(e.g.
COVID-19)
Similarly,
exhibited
selective
response
toward
cancer
types
engaging
different
targets
signaling
pathways.
These
results
are
favor
primary
function
which
homeostatic
maintenance.
Conclusion:
The
presented
evidence
suggests
prominent
target
autoimmune
diseases,
infections,
neurological
psychological
pathologies,
cancer.
Moreover,
have
suggested
to
be
potentially
used
combination
with
chemo-
or
immunotherapy
However,
clinical
still
lacking,
raises
challenge
apply
translational
cannabis
research
human
Cancers,
Journal Year:
2022,
Volume and Issue:
14(23), P. 5933 - 5933
Published: Nov. 30, 2022
A
significant
proportion
of
cancer
patients
use
forms
complementary
medicine
or
therapies.
An
integrative
approach
to
management
combines
conventional
with
evidence-based
medicines/therapies
and
lifestyle
interventions,
for
the
treatment
prevention
disease
optimisation
health.
Its
basis
is
a
holistic
one;
treat
whole
person,
not
just
disease.
It
makes
adjunct
technologies
which
may
assist
clinician
in
diagnosis
early
carcinogenesis
monitoring
effectiveness.
Many
factors
contribute
development
including
some
are
largely
modifiable
by
patient
oncologists
be
position
advise
on,
such
as
stress,
poor
nutrition,
lack
physical
activity,
sleep,
Vitamin
D
deficiency.
addressing
these
better
overall
health
outcomes.
Evidence-based
approaches
include
supplements,
herbal
medicine,
various
practices
that
reduce
Individualised
patient,
can
also
help
address
symptoms
signs
associated
its
orthodox
treatment.
The Journal of Clinical Endocrinology & Metabolism,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 12, 2024
Abstract
Context
Treatment
options
for
advanced
neuroendocrine
tumors
(NETs),
pheochromocytomas
and
paragangliomas
(PPGLs)
are
still
limited.
In
recent
years,
antitumor
effects
of
cannabinoids
have
been
reported;
however,
there
only
very
limited
data
available
in
NETs
or
PPGLs.
Objective
Investigation
the
cannabidiol
(CBD)
on
patient-derived
human
NET/PPGL
primary
cultures
cell
lines.
Methods
We
established
derived
from
46
different
patients
with
PPGLs
(n
=
35)
11)
who
underwent
tumor
resection
at
2
centers.
patient
clinically
relevant
doses
(5
µM)
slightly
higher
(10
CBD
was
performed.
Results
found
opposing
5
µM
CBD:
significant
5/35
(14%)
tumor-promoting
6/35
(17%)
PPGL
cultures.
terms
effects,
cluster
2-related
showed
significantly
stronger
responsivity
to
compared
1-related
(P
.042).
Of
tumors,
NF1
strongest
(4/5
a
decrease
viability
were
NF1-mutated).
also
10
NETs:
9/33
(27%)
3/11
NET
6/33
(18%)
2/11
Conclusion
suggest
potential
novel
treatment
option
some
NETs/PPGLs
but
provide
evidence
caution
when
applying
as
supportive
therapy
pain
appetite
management
cancer
possibly
health
supplements.
Cannabis and Cannabinoid Research,
Journal Year:
2023,
Volume and Issue:
8(5), P. 716 - 730
Published: May 30, 2023
Background:
Parkinson's
disease
(PD)
is
a
serious
neurodegenerative
condition
impacting
many
individuals
worldwide.
There
need
for
new
non-invasive
treatments
of
PD.
Cannabinoids
in
the
form
cannabidiol
(CBD)
and
delta-9-tetrahydrocannabinol
(THC)
may
offer
utility
as
treatment,
our
objective
was
hence
to
conduct
systematic
review
regarding
clinical
evidence
efficacy
safety
cannabinoids
treating
Methods:
Screening,
data
extraction,
quality
assessments
were
all
conducted
by
multiple
reviewers,
with
discrepancies
resolved
consensus.
Results:
After
conducting
searches
4
different
databases,
673
articles
screened.
Thirteen
deemed
eligible
inclusion
this
review.
It
shown
that
cannabis,
CBD,
nabilone
(a
synthetic
THC)
capable
consistently
improving
motor
symptoms
more
than
placebo.
All
improved
various
non-motor
symptoms,
particularly
cannabis
pain
intensity,
CBD
psychiatric
dose-dependent
manner.
Adverse
effects
usually
minor,
and,
case
rare
(except
at
very
high
doses).
Conclusion:
have
been
safely
important
potential
PD
some
symptoms.
More
large-scale
randomized
control
trials
specific
forms
cannabinoid
are
required
determine
their
overall
efficacy.
