Changes in ADAR1 activity duringPlasmodiuminfection contribute to protection from malaria DOI Creative Commons
Jaclyn Quin, Eli Kopel, Riem Gawish

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 7, 2023

Summary Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the activation of multiple antiviral immune response pathways. Here, we investigate role ADAR1 during infection with Plasmodium parasite, which causes malaria and is responsible for over almost a half million childhood deaths every year. Reduced activity associated populations protected from clinical malaria. In animal models, Adar +/- mice are P. yoelii parasitemia, via previously unreported pathway. These display elevated Type-I IFN responses CD8 + T cell activation, but no detrimental responses. Our results suggest that decrease in levels occurs can drive both innate adaptive responses, this presents unrecognized opportunity targeting diverse infectious diseases.

Language: Английский

A Case Report of Plasmodium Malaria Infection DOI Open Access

Welly Salutondok,

Nolly Octavianes Habel Rantung,

Ronny

et al.

Galore International Journal of Health Sciences and Research, Journal Year: 2025, Volume and Issue: 9(4), P. 105 - 108

Published: Jan. 8, 2025

Background: Malaria is a human infection caused by Plasmodium species. The Indonesia Ministry of Health reported 418,546 positive cases malaria in throughout 2023. Among the five major species, malariae relatively rare and often overlooked light microscopy due to its low parasitemia. Case Report: A 67-year-old female presented emergency room with fever for almost one week. went down three days but rose again on fourth day. patient had history traveling Papua. Vital signs were normal. Laboratory examinations revealed decreased levels hemoglobin, erythrocytes, leukocytes, platelets, hematocrite. serological examination was malaria, occult blood detected schizont. subsequently treated combination drug therapy recovered successfully. Conclusion: symptoms attributed infection. Treatment artemisinin-based most effective anti-malarial drug. Early accurate diagnosis also crucial delays appropriate treatment could result severe complications. Keywords: plasmodium malariae, tropical

Language: Английский

Citations

0
Overview of the host immune response to P. falciparum malaria DOI
Samuel Antwi‐Baffour,

Benjamin Tetteh Mensah,

Lawrence Annison

et al.

Journal of Parasitic Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
Sialic Acids in Health and Disease DOI Creative Commons
Gerardo N. Guerrero-Flores,

Fayth M. Butler,

Verónica L. Martínez‐Marignac

et al.

Biologics, Journal Year: 2025, Volume and Issue: 5(2), P. 10 - 10

Published: March 26, 2025

Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due widespread distribution strategic positioning, acids play a crucial role in mediating regulating wide range physiologic processes pathologic conditions. Human- animal-based investigations predominantly concentrate on the effects during infections, inflammations, vascular disorders, cancers. Further encompass variety applications, including cell–cell interactions, signaling, host–pathogen other biological functions associated nutrition, metabolism, genetic disorders. Nevertheless, future mechanistic needed clarify specific roles these varied contexts, so that more effective interventions may be developed.

Language: Английский

Citations

0
Plant-derived nanomaterials (PDNM): a review on pharmacological potentials against pathogenic microbes, antimicrobial resistance (AMR) and some metabolic diseases DOI Creative Commons
Emmanuel Sunday Okeke, Ekene John Nweze, Emeka Godwin Anaduaka

et al.

3 Biotech, Journal Year: 2023, Volume and Issue: 13(9)

Published: Aug. 4, 2023

Abstract Plant-derived nanomaterials (PDNM) have gained significant attention recently due to their potential pharmacological applications against pathogenic microbes, antimicrobial resistance (AMR), and certain metabolic diseases. This review introduces the concept of PDNMs unique properties, including small size, high surface area, ability penetrate biological barriers. Besides various methods for synthesizing PDNMs, such as green synthesis techniques that utilize plant extracts natural compounds, advantages using plant-derived materials, biocompatibility, biodegradability, low toxicity, were elucidated. In addition, it examines recent emerging trends in derived from approaches combat The sizes areas are vital they play essential roles interactions relationships between these materials components or organization. We critically analyze biomedical nanoparticles which include antibacterial composites implantable devices nanosystems resistance, enhance antibiotic delivery, improve microbial diagnostic/detection systemsIn can potentially interfere with syndrome pathways; hence most nano-formulations reduce chronic inflammation, insulin oxidative stress, lipid profile, resistance. As a result, innovative plant-based may be promising contender applications.

Language: Английский

Citations

8
Conserved proteins of Eimeria and their applications to develop universal subunit vaccine against chicken coccidiosis DOI Creative Commons

Lixin Xu,

Xiangrui Li

Veterinary Vaccine, Journal Year: 2024, Volume and Issue: 3(2), P. 100068 - 100068

Published: May 27, 2024

Chicken coccidiosis caused by the Eimeria parasites, including E. acervuline, brunetti, maxima, mitis, necatrix, praecox and tenella, is one of most economically important chicken diseases. The main measure to control chemoprophylaxis. However, concerns public about over chemical residues in products strict legislation limit applications drugs push farmers turn vaccination strategy coccidiosis. While antigen diversity significantly decreased traditional live vaccines. cryptic strains Eimeria, which have recently appeared spread widely, can evade all commercial vaccines, thus becoming an emerging threat global poultry production. For this reason, development universal subunit vaccines using conserved proteins effective against species infecting chickens, crucial for sustainable industry. In article, we reviewed research progresses on stage proteins, both with their possible Meanwhile, cytokines polymer-based nanomaterials used as adjuvants enhance protections were also summarized.

Language: Английский

Citations

1
Exploring the potency of wild sage (Salvia officinalis): UPLC-PDA-ESi-MS phytochemical profiling and inhibitory activity against β-Hematin DOI
Saleh Abu‐Lafi,

Carine Said,

Qassem Abu-Remeleh

et al.

Pharmacy & Pharmacology International Journal, Journal Year: 2024, Volume and Issue: 12(3), P. 108 - 116

Published: July 5, 2024

The current study employed a semi-quantitative approach to investigate the inhibitory effects of water-extracted wild sage (Salvia officinalis) on β-hematin formation in vitro. Spectrophotometric analysis over nine-day period evaluated antimalarial efficacy water and sodium bicarbonate extracts derived from leaves. Results indicated that exhibited superior in-vitro effectiveness against malaria compared extracts. Furthermore, both marginal decrease nine days. Polyphenols present extract were analyzed using UPLC coupled photodiode array quadrupole mass spectrometry (LC-PDA-ESi-MS). Key compounds identified included Hispidulin-7-glucuronide, Luteolin-7-O-rutinoside, Apigenin-7-O-glucoside, Luteolin-7-O-glucuronide, Rosmarinic acid, Isorhamnetin, Hispidulin, Pectolinarigenin, Epirosmanol, Genkwanin, Carnosol, Carnosic Hesperetin, Rosmaridiphenol. diverse polyphenols effectively formed complexes with free heme, thereby preventing β-hematin, which is crucial for disrupting plasmodium parasite during its intraerythrocytic stage.

Language: Английский

Citations

1
Dynamics of osteopontin levels and correlation with parasitemia in acute malaria in Uganda and Sweden DOI Creative Commons

Susanne E. Mortazavi,

Allan Lugaajju,

Lena Danielsson

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 15, 2024

Malaria remains a significant public health concern, especially for the deadliest parasite, Plasmodium falciparum. During acute malaria, various cytokines, including osteopontin (OPN), regulate immune response. OPN has been shown to be protective against malaria in mice. Nonetheless, its precise function and potential ability control parasites during humans remain poorly understood.

Language: Английский

Citations

1
Therapeutic Benefits of Vernonia amygdalina in the Treatment of Inflammation and its Associated Diseases DOI Creative Commons
Du-Bois Asante, Gideon Akuamoah Wiafe, Korantema Mawuena Tsegah

et al.

Clinical Complementary Medicine and Pharmacology, Journal Year: 2023, Volume and Issue: 4(1), P. 100122 - 100122

Published: Nov. 15, 2023

In the presence of a stimulus that disrupts homeostasis, body elicits response known as inflammation. The inflammatory is expected to restore normal functioning and initiate healing where necessary. However, persistent activity acute inflammation results in chronic which causes adverse consequences associated with diseases such diabetes arthritis. traditional medical practice, Vernonia amygdalina used treat several ailments malaria, fever, diabetes, conditions those related pain swelling. This review seeks explore discuss therapeutic benefits V. treatment its diseases. We reviewed scientific literature indexed PubMed, ScienceDirect Springer discussed reported anti-inflammatory properties curative inflammation-associated A total 30 published articles were identified describing effect predominately experimental models. have been linked bioactive phytoconstituents predominantly present leaves plant. Multiple studies demonstrated aqueous ethanolic extracts can inhibit production proinflammatory cytokines enzymes cells, reducing complications. critically appraise current evidence, potential use this medicinal plant conditions.

Language: Английский

Citations

3
Host directed immunotherapy for chronic infections and cancer DOI
Rahul Kumar Tiwari, Vishal Kumar Singh, Vibhav Gautam

et al.

Advances in protein chemistry and structural biology, Journal Year: 2024, Volume and Issue: unknown, P. 355 - 388

Published: Dec. 20, 2024

Language: Английский

Citations

0
Changes in ADAR1 activity duringPlasmodiuminfection contribute to protection from malaria DOI Creative Commons
Jaclyn Quin, Eli Kopel, Riem Gawish

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 7, 2023

Summary Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the activation of multiple antiviral immune response pathways. Here, we investigate role ADAR1 during infection with Plasmodium parasite, which causes malaria and is responsible for over almost a half million childhood deaths every year. Reduced activity associated populations protected from clinical malaria. In animal models, Adar +/- mice are P. yoelii parasitemia, via previously unreported pathway. These display elevated Type-I IFN responses CD8 + T cell activation, but no detrimental responses. Our results suggest that decrease in levels occurs can drive both innate adaptive responses, this presents unrecognized opportunity targeting diverse infectious diseases.

Language: Английский

Citations

0