Nutritional interventions during treatment for ovarian cancer: A narrative review and recommendations for future research

Maturitas, Journal Year: 2024, Volume and Issue: 183, P. 107938 - 107938

Published: Feb. 10, 2024

Most women with ovarian cancer are diagnosed at an advanced stage (stage III or IV), when the intraabdominal spread of tumour impacts nutrient intake and absorption. Up to 70 % malnourished approximately 40 affected by muscle loss time diagnosis. Women high risk nutritional decline during invasive treatment severity side-effects. This review explores evidence evaluating interventions for their effect on status, mass, clinical outcomes. Perioperative immunonutrition has been investigated mixed results immediate postoperative Individualised nutrition counselling as part a multimodal prehabilitation programme prior surgery shows promising results; however, effects limited sample size. Nutrition intervention exercise acceptability suggests improvements in dietary quality life chemotherapy treatment, while oral supplements education appear reduce symptom burden. also appears be associated improved overall survival; is single retrospective study. A key finding from this that, despite prevalence malnutrition critical importance addressing these modifiable prognostic factors, studies limited. Prospective samples large enough provide adequate power evaluate effectiveness urgently required inform optimal management.

Language: Английский

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Effect on an Oral Nutritional Supplement with β-Hydroxy-β-methylbutyrate and Vitamin D on Morphofunctional Aspects, Body Composition, and Phase Angle in Malnourished Patients

Nutrients, Journal Year: 2021, Volume and Issue: 13(12), P. 4355 - 4355

Published: Dec. 3, 2021

This is a retrospective study of data from clinical practice to observe the effect high-calorie, high-protein oral nutritional supplement (ONS) with β-hydroxy-β-methylbutyrate (HMB) on status, body weight, and muscle-related parameters in 283 adult patients or at risk malnutrition under standard care, 63% being cancer patients. They were recommended increase physical activity energy protein intake regular diet plus two servings per day specialized ONS enriched HMB for up 6 months. Dietary records, adherence tolerance ONS, composition, handgrip strength, blood analysis beginning end intervention recorded. program improved status 100% malnourished baseline 80% well-nourished final visit. It also increased weight by 3.6-3.8 kg, fat-free mass 0.9 1.3 strength 4.7 6.2 kg. In subgroup (n = 43), phase angle (PhA), cell (BCM) only receiving (0.95 (0.13) vs. -0.36 (0.4), 2.98 (0.5) -0.6 (1.5) mean difference (SE) PhA BCM, respectively), suggesting potential efficacy this muscle health.

Language: Английский

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Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3391 - 3391

Published: July 30, 2023

Cancer cachexia is a multi-organ syndrome with unintentional weight loss, sarcopenia, and systemic inflammation. Gastrointestinal (GI) cancer patients are more susceptible to development due impaired nutrient absorption digestion. Given the widespread availability relatively low cost of dietary supplements, we examined evidence effects fish oil (omega-3 fatty acids), melatonin, probiotics, green tea for managing symptoms GI cachexia. A literature review four specific supplements was conducted using PubMed, Google Scholar, CINAHL without date restriction. Of 4621 available references, 26 articles were eligible review. Fish decreased C-reactive protein maintained CD4+ cell count, while melatonin indicated inconsistent findings on cachexia, but well-tolerated. Probiotics serum pro-inflammatory biomarkers increased tolerability chemotherapy by reducing side effects. Green preparations extracts showed risk developing various cancers did not impact tumor growth, survival, or adverse Among these probiotics most promising further research in preventing inflammation maintaining adequate nutrients prevent progression Supplements may benefit treatment outcomes supporting nutritional therapeutic needs.

Language: Английский

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Neuroendocrine Tumors: A Comprehensive Review on Nutritional Approaches

Cancers, Journal Year: 2022, Volume and Issue: 14(18), P. 4402 - 4402

Published: Sept. 10, 2022

Neuroendocrine neoplasms are a heterogeneous group of with increasing incidence, high prevalence, and survival worldwide. About 90% cases well differentiated forms, the so-called neuroendocrine tumors (NETs), slow proliferation rates prolonged but frequent development liver metastases endocrine syndromes. Both tumor itself systemic therapy may have an impact on patient nutrition. Malnutrition has negative outcome in patients NETs, as obesity. In addition, obesity metabolic syndrome been shown to be risk factors for both prognosis NET. Therefore, dietary assessment based body composition lifestyle modifications should integral part treatment NET patients. Nutrition plans, properly formulated by dietician, multidisciplinary team NETs because they allow improvement quality life, providing tailored approach nutritional needs manageable signs and/or symptoms related pharmacological treatment. The aim this review is condense latest evidence role most used models, Mediterranean diet, ketogenic intermittent fasting, context while considering clinical molecular mechanisms which these models act.

Language: Английский

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Are measures and related symptoms of cachexia recorded as outcomes in gastrointestinal cancer chemotherapy clinical trials?

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(3), P. 1146 - 1156

Published: March 27, 2024

Cachexia is prevalent in gastrointestinal cancers and worsens patient outcomes chemotherapy compliance. We examined to what extent registered cancer clinical trials record measures related symptoms of cachexia as outcomes, whether these were associated with trial characteristics.

Language: Английский

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