Melittin inhibits MPP⁺-induced HT22 cell death by suppressing Bax activation and improving mitochondrial function

Korean Journal of Physiology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Melittin (MEL) is the main bioactive component of bee venom and has been reported to have various pharmacological effects. This study investigates protective effect MEL on MPP

Language: Английский

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Viruses and neurodegeneration: a growing concern

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 12, 2025

Abstract Neurodegenerative diseases (NDDs) cause a progressive loss of neurons. Since NDDs are multifactorial, the precise etiology varies on basis type disease and patient history. Cohort studies case have demonstrated potential link between viral infections onset or progression NDDs. Recent findings concerning mechanisms by which neuropathic occur provided more insights into importance such connections. In this review, we aim to elaborate occurrence effects viruses from epidemiological, clinical, biological perspectives while highlighting treatments challenges. One key players in neuropathogenesis is neuroinflammation caused immune response virus; can due both neurotropic nonneurotropic viruses. The COVID-19 pandemic has raised concerns about whether vaccines essential for preventing may play part exacerbating accelerating By classifying common associated with them further delving their cellular pathways, review provides advance development diagnostic methods. Graphical

Language: Английский

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Alzheimer’s and Parkinson’s Diseases in Relation to Human Papillomavirus Infection: A Two-Sample Mendelian Randomization Study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Background An increasing number of studies are exploring links between Human papillomavirus (HPV) infection and neurodegenerative diseases. Yet, existing evidence from retrospective is prone to bias cannot confirm causation. To address this, our two-sample Mendelian randomization (MR) study utilizing single nucleoside polymers (SNPs) aims establish a potential causal connection HPV the onset Alzheimer's (AD) Parkinson's (PD). Methods We utilized MR approach evaluate relationships HPV16 HPV18 E7 proteins, seropositivity, risks Selected SNPs genome wide association (GWAS) served as instrumental variables (IVs) in exposure data for analysis. Subsequent rigorous sensitivity assessments were also performed ensure robustness. Results In this research, we explored connections development AD or PD through Our findings suggest that protein might act protective factor against PD, whereas seropositivity was recognized risk same condition. Interestingly, neither nor appeared have any significant impact on AD. Conclusions These shed light HPV's intricate involvement diseases, offering fresh views viral impacts disorders like Recognizing limitations, further research crucial clarify exact effects these conditions.

Language: Английский

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Neurologic Complications of Influenza and Potential Protective Vaccine Effects

Influenza and Other Respiratory Viruses, Journal Year: 2025, Volume and Issue: 19(3)

Published: March 1, 2025

Influenza is a common respiratory infection affecting persons of all ages and results in significant morbidity mortality. Respiratory complications are well known, but important nonpulmonary less recognized. Neurologic following influenza may accompany the acute illness or be chronic nature. The such as seizures, encephalitis, myelitis Guillain Barre Syndrome documented fortunately uncommon. However, stroke dementia leading causes death disability worldwide, there increasing evidence linking these devasting illnesses with influenza. In addition, vaccine has been associated protective effects against risk.

Language: Английский

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A Parkinson's Auxiliary Diagnosis Algorithm Based on a Hyperparameter Optimization Method of Deep Learning

IEEE/ACM Transactions on Computational Biology and Bioinformatics, Journal Year: 2023, Volume and Issue: 21(4), P. 912 - 923

Published: Feb. 22, 2023

Parkinson's disease is a common mental in the world, especially middle-aged and elderly groups. Today, clinical diagnosis main diagnostic method of disease, but results are not ideal, early stage disease. In this paper, auxiliary algorithm based on hyperparameter optimization deep learning proposed for diagnosis. The system uses ResNet50 to achieve feature extraction classification, mainly including speech signal processing part, improvement part Artificial Bee Colony (ABC) optimizing hyperparameters part. improved called Gbest Dimension (GDABC), proposing "Range pruning strategy" which aims at narrowing scope search "Dimension adjustment adjust gbest dimension by dimension. accuracy verification set Mobile Device Voice Recordings King's College London (MDVR-CKL) dataset can reach more than 96%. Compared with current sound methods other algorithms, our shows better classification performance within limited time resources.

Language: Английский

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Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4330 - 4330

Published: April 14, 2024

Parkinson's disease (PD) is a chronic, age-related, progressive multisystem associated with neuroinflammation and immune dysfunction. This review discusses the methodological approaches used to study changes in central peripheral immunity PD, advantages limitations of techniques, their applicability humans. Although single animal model cannot replicate all pathological features human disease, present most models PD plays critical role understanding involvement system (IS) pathogenesis PD. The IS its interactions different cell types nervous (CNS) play an important Even though culture do not fully reflect complexity progression, they are limited ability mimic long-term effects need validation through vivo studies. They indispensable tool for interplay between this disease. Understanding immune-mediated mechanisms may lead potential therapeutic targets treatment We believe that development guidelines experiments patients crucial ensure validity consistency results.

Language: Английский

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Neurotropic virus infection and neurodegenerative diseases: Potential roles of autophagy pathway

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(6)

Published: Dec. 11, 2023

Abstract Neurodegenerative diseases (NDs) constitute a group of disorders characterized by the progressive deterioration nervous system functionality. Currently, precise etiological factors responsible for NDs remain incompletely elucidated, although it is probable that combination aging, genetic predisposition, and environmental stressors participate in this process. Accumulating evidence indicates viral infections, especially neurotropic viruses, can contribute to onset progression NDs. In review, emerging supporting association between infection summarized, how autophagy pathway mediated cause pathological aggregation cellular proteins associated with various discussed. Furthermore, autophagy‐related genes (ARGs) involved Herpes simplex virus (HSV‐1) are analyzed, whether these could link HSV‐1 Elucidating mechanisms underlying critical developing targeted therapeutic approaches prevent slow

Language: Английский

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SARS-CoV-2 and Parkinson’s Disease: A Review of Where We Are Now

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2524 - 2524

Published: Sept. 13, 2023

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has been discussed in the context of Parkinson’s (PD) over last three years. Now that we are entering long-term phase this pandemic, intrigued to look back and see how why community patients with PD was impacted what knowledge have collected so far. The relationship between COVID-19 is likely multifactorial nature. Similar other systemic infections, a probable worsening symptoms secondary COVID-19, either transient or persistent (long COVID), demonstrated, while COVID-19-related mortality may be increased compared general population. These observations could attributed direct indirect damage from SARS-CoV-2 central nervous system (CNS) result infection-related parameters (e.g., hospitalization drugs) sequelae pandemic quarantine). A growing number cases new-onset parkinsonism following infection reported, closely (post-infectious) remotely (para-infectious) after diagnosis, although such link remains hypothetical. pathophysiological substrate these phenomena elusive; however, research studies, particularly pathology suggested various COVID-19-induced degenerative changes potential associations PD/parkinsonism. We review literature date for answers considering PD/parkinsonism, examining pathophysiology, clinical manifestations, vaccination, future directions.

Language: Английский

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Epstein–Barr Virus: Human Interactome Reveals New Molecular Insights into Viral Pathogenesis for Potential Therapeutics and Antiviral Drug Discovery

OMICS A Journal of Integrative Biology, Journal Year: 2024, Volume and Issue: 28(1), P. 32 - 44

Published: Jan. 1, 2024

Host-virus Protein–Protein Interactions (PPIs) play pivotal roles in biological processes crucial for viral pathogenesis and by extension, inform antiviral drug discovery therapeutics innovations. Despite efforts to develop the Epstein–Barr virus (EBV)-host PPI network, there remain significant knowledge gaps a limited number of interacting human proteins deciphered. Furthermore, understanding dynamics EBV-host network distinct lytic latent stages remains elusive. In this study, we report comprehensive map EBV–human protein interactions, encompassing 1752 61 EBV integrating data from public repository HPIDB (v3.0) as well curated high-throughput proteomic literature. To address stage-specific nature infection, generated two detailed subset networks representing stages, comprising 747 481 proteins, respectively. Functional pathway enrichment analysis these subsets uncovered profound impact on cancer. The identification highly connected characterization intrinsically disordered cancer-related provide valuable insights into potential therapeutic targets. Moreover, exploration drug–protein interactions revealed notable associations between hub anticancer drugs, offering novel perspectives controlling pathogenesis. This study represents, best our knowledge, first investigation infection using datasets. makes contribution EBV–host provides foundation future interventions.

Language: Английский

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The Development of Near-infrared Hydrogen Sulfide Probes and Its Application in the Past Ten Years

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 228, P. 112246 - 112246

Published: May 28, 2024

Language: Английский

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