Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4165 - 4165

Published: April 9, 2024

Plant-derived multitarget compounds may represent a promising therapeutic strategy for multifactorial diseases, such as Alzheimer’s disease (AD). Artemisinin and its derivatives were indicated to beneficially modulate various aspects of AD pathology in different animal models through the regulation wide range cellular processes, energy homeostasis, apoptosis, proliferation inflammatory pathways. In this review, we aimed provide an up-to-date overview experimental evidence documenting neuroprotective activities artemi-sinins underscore potential these already-approved drugs treating also humans propose their consideration carefully designed clinical trials. particular, benefits main pathological hallmarks events cascade throughout development are summarized. Moreover, dose- context-dependent effects artemisinins noted.

Language: Английский

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Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Abstract Due to the significance of variable chemical groups across a wide spectrum modern medicine, it is imperative determine what most widely used group in medical applications with fewest side effects. Ten compounds from ten that are commonly known for their uses were compared terms therapeutic potential and The comparison among selected indicated superiority flavonoids over other multitude utilizations lower Kaempferol quercetin showed higher utilization Whereas alkaloid lowest levels use highest Based on conducted, concluded give priority flavonoid being because they exhibit Within flavonoids, kaempferol two highly recommended be widest range applications. Serious caution should considered before applying alkaloids any service. Understanding characteristics these can aid developing safer more effective treatments medicinal plants.

Language: Английский

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Anti-malarial drug: the emerging role of artemisinin and its derivatives in liver disease treatment

Chinese Medicine, Journal Year: 2021, Volume and Issue: 16(1)

Published: Aug. 18, 2021

Abstract Artemisinin and its derivatives belong to a family of drugs approved for the treatment malaria with known clinical safety efficacy. In addition anti-malarial effect, artemisinin displays anti-viral, anti-inflammatory, anti-cancer effects in vivo vitro. Recently, much attention has been paid therapeutic role liver diseases. Several studies suggest that can protect through different mechanisms, such as those pertaining inflammation, proliferation, invasion, metastasis, induction apoptosis autophagy. this review, we provide comprehensive discussion underlying molecular mechanisms signaling pathways treating Further pharmacological research will aid determining whether may serve promising medicines diseases future.

Language: Английский

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Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113705 - 113705

Published: Oct. 7, 2022

Lung cancer is the leading cause of cancer-related death worldwide. The development epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immune checkpoint (ICIs) has brought favorable survival benefits to patients with non-small-cell lung (NSCLC); unfortunately, acquired drug resistance remains a major barrier treatment NSCLC. Recent studies have demonstrated that transcriptional co-activator PDZ-binding motif (TAZ, also called WWTR1) induces tumor evasion by directly modulating expression programmed ligand 1 (PD-L1), key therapeutic target for immunotherapy. Moreover, aberrant activation TAZ mechanism EGFR-TKIs in Therefore, signaling blockade might be an effective strategy overcome ICIs In this study, we showed first time artesunate effectively reduced PD-L1 We further suppressed TAZ/PD-L1-induced T-cell inhibition vitro enhanced anti-tumor immunity recruiting infiltrating CD8 + T-cells syngeneic mouse models. Artesunate inhibited stem cell-like properties NSCLC cells xenografts bearing gefitinib-resistant tumors. addition, our results molecular docking cellular thermal shift assay analysis suggested TAZ-TEAD complex induce proteasome-dependent degradation cells. These suggest overcame EGFR-TKI at least part suppressing TAZ/PD-L1 signaling.

Language: Английский

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Redox modulating small molecules having antimalarial efficacy

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 218, P. 115927 - 115927

Published: Nov. 20, 2023

Language: Английский

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