Anti-tumor mechanism of artesunate DOI Creative Commons
Xiaoyu Fan, Yiming Yan, Yafei Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 25, 2024

Artesunate (ART) is a classic antimalarial drug with high efficiency, low toxicity and tolerance. It has been shown to be safe good anti-tumor effect. Existing clinical studies have that the mechanisms of ART mainly include inducing apoptosis autophagy tumor cells, affecting microenvironment, regulating immune response, overcoming resistance, as well inhibiting cell proliferation, migration, invasion, angiogenesis. proven fight against lung cancer, hepatocarcinoma, lymphoma, multiple myeloma, leukemia, colorectal ovarian cervical malignant melanoma, oral squamous carcinoma, bladder prostate cancer other neoplasms. In this review, we highlight effects on various tumors an emphasis its mechanism, which helpful propose potential research directions expand application.

Language: Английский

Artesunate—multiple pharmacological effects beyond treating malaria DOI
Yuan‐Shiun Chang, Tong Lyu, Xiaojie Luan

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 286, P. 117292 - 117292

Published: Jan. 18, 2025

Language: Английский

Citations

1
Artesunate induces melanoma cell ferroptosis and augments antitumor immunity through targeting Ido1 DOI Creative Commons
Wuyi Liu, Huyue Zhou,

Wenjing Lai

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 26, 2024

Artesunate (ART), a natural product isolated from traditional Chinese plant Artemisia annua, has not been extensively explored for its anti-melanoma properties. In our study, we found that ART inhibited melanoma cell proliferation and induced ferroptosis. Mechanistic study revealed directly targets Ido1, thereby suppressing Hic1-mediated transcription suppression of Hmox1, resulting in CD8+ T cells, does cause ferroptosis due to the low expression Hmox1. It also elevating tryptophan levels, which inhibits NFATc1-mediated PD1 transcription, consequently activating cells. Our uncovered potent synergistic efficacy arising ART-induced concurrently enhancing cell-mediated immune response both vivo vitro through targeting Ido1. provides novel mechanistic basis utilization as an Ido1 inhibitor application clinical treatment.

Language: Английский

Citations

5
Strategies that regulate Hippo signaling pathway for novel anticancer therapeutics DOI

Na Li,

Yunhe Liu,

Ji Yuan Wu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 116694 - 116694

Published: July 20, 2024

Language: Английский

Citations

4
Potential regulation of artesunate on bone metabolism through suppressing inflammatory infiltration in type 2 diabetes mellitus DOI
Jinghong Luo, Kun Chen, Xiaolin Nong

et al.

Immunopharmacology and Immunotoxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 6, 2025

Objective Osteoimmunology is an emerging field that explores the interplay between bone and immune system. The system plays a critical role in pathogenesis of diabetes significantly affects homeostasis. Artesunate, first-line treatment for malaria, known its low toxicity multifunctional properties. Increasing evidence suggests artesunate possesses anti-inflammatory, immunoregulatory, osteogenic effects. This review aims to explore relationship regulation metabolism type 2 (T2DM) investigate potential therapeutic application artesunate.

Language: Английский

Citations

0
Unravelling key signaling pathways for the therapeutic targeting of non-small cell lung cancer DOI

P. Chavan,

Ruchi Pandey,

BHEEMANAGOUDA O. PATIL

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177494 - 177494

Published: March 1, 2025

Language: Английский

Citations

0
Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity DOI
Ziyu Guo,

Yihuang Liu,

Danyao Chen

et al.

Journal of Translational Internal Medicine, Journal Year: 2025, Volume and Issue: 13(1), P. 10 - 32

Published: Feb. 1, 2025

In the evolving landscape of cancer treatment, strategic manipulation regulated cell death (RCD) pathways has emerged as a crucial component effective anti-tumor immunity. Evidence suggests that tumor cells undergoing RCD can modify immunogenicity microenvironment (TME), potentially enhancing its ability to suppress progression and metastasis. this review, we first explore mechanisms apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, along with crosstalk between these modalities. We then discuss how processes activate antigen-presenting cells, facilitate cross-priming CD8+ T trigger immune responses, highlighting complex effects novel forms on TME biology. Furthermore, summarize potential drugs nanoparticles induce or inhibit emerging their therapeutic roles in treatment. Finally, put forward existing challenges future prospects for targeting anti-cancer Overall, review enhances our understanding molecular biological impacts RCD-based therapies, providing new perspectives strategies

Language: Английский

Citations

0
Research advances in natural sesquiterpene lactones: overcoming cancer drug resistance through modulation of key signaling pathways DOI Open Access

Chi Teng,

Jiawen Chen, Lisha Shen

et al.

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Cancer remains a significant global health challenge, with current chemotherapeutic strategies frequently limited by the emergence of resistance. In this context, natural compounds potential to overcome resistance have garnered considerable attention. Among these, sesquiterpene lactones, primarily derived from plants in Asteraceae family, stand out for their anticancer properties. This review specifically focuses on five key signaling pathways: PI3K/Akt/mTOR, NF-κB, Wnt/β-catenin, MAPK/ERK, and STAT3, which play central roles mechanisms cancer For each these pathways, we detail involvement both development drug Additionally, investigate how lactones modulate pathways across diverse types. These insights highlight drive advancement novel therapies that can effectively combat progression

Language: Английский

Citations

0
Combined Photothermal/Combination Chemotherapeutic Approach Using Zif-8-Supported Artesunate and Gold Nanorods DOI
Xing Li, Jun Wang, Wanzhen Li

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(10), P. 11587 - 11598

Published: May 10, 2024

Tumors pose a significant threat to human well-being, presenting substantial risks lives. Conventional approaches cancer treatment exhibit limited efficacy in eliminating the disease, leading undesirable outcomes and an increased likelihood of disease relapse. The application chemotherapy photothermal therapy has recently shown increasing trend, owing their negative effects exceptional specificity. Chemotherapy can potentially induce rapid reduction tumors during initial treatment. However, it carries risk inducing drug resistance, ultimately contributing tumor recurrence. Combination offers more advantages, than single chemotherapy. Photothermotherapy photodynamic have gained public interest as innovative medical Nonetheless, gold nanorods demonstrate notable potential agents therapy. An acidic microenvironment is commonly found tumors. With this factor considered, tumor-specific cleavable material used encapsulate for facilitating controlled release exclusively within microenvironment. combination dequalinium chloride artesunate increases its selectivity toward mitochondria, enhancing effectiveness agent. were successfully employed with ZIF-8, enabling precise transportation location while preserving stability. therapeutic on mouse models NCI-H1299 was highly satisfactory, also demonstrating high biological safety, revealing capabilities It provides research basis nanomaterials inhibit

Language: Английский

Citations

3
Artesunate Inhibits the Growth of Insulinoma Cells via SLC7A11/ GPX4-mediated Ferroptosis DOI Creative Commons

Fengping Chen,

Jiexia Lu,

Biaolin Zheng

et al.

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(3), P. 230 - 239

Published: Jan. 1, 2024

Background: Artesunate (ART) has been recognized to induce ferroptosis in various tumor phenotypes, including neuroendocrine tumors. We aimed investigate the effects of ART on insulinoma and underlying mechanisms by focusing process ferroptosis. Methods: The CCK8 colony formation assays were conducted assess effectiveness ART. Lipid peroxidation, glutathione, intracellular iron content determined validate ferroptosis, while ferrostatin-1 (Fer-1) was employed as inhibitor Subcutaneous models established treated with ferroptosis-associated proteins western blot immunohistochemistry assays. Pathological structures liver examined hematoxylin-eosin staining. Results: suppressed growth both vitro vivo. Insulinoma cells revealed signs increased lipid diminished glutathione levels, ascending iron. Notably, ART-treated exhibited a decline expressions catalytic component solute carrier family 7 member 11 (SLC7A11) peroxidase 4 (GPX4). These alterations negated Fer-1. Moreover, no hepatotoxicity observed upon therapeutic dose Conclusion: might regulate through SLC7A11/GPX4 pathway.

Language: Английский

Citations

2
Artesunate reverses cytarabine resistance in acute myeloid leukemia by blocking the JAK/STAT3 signaling DOI Creative Commons
Qiong Su, Pei Huang, Xi Luo

et al.

Hematology, Journal Year: 2023, Volume and Issue: 28(1)

Published: Oct. 10, 2023

Although cytarabine (AraC) has greatly contributed to improving the prognosis of patients with acute myeloid leukemia (AML), many developed drug resistance and eventually succumbed AML. Thus, AraC is a major obstacle improve efficacy chemotherapy in Hence, this study aimed demonstrate that artesunate (ART) can reliably induce cell death vitro block resistance.AML lines resistant were first constructed by repeated dosing for 5 months. Further, we analyzed whether ART intervention affected sensitivity AraC-resistant cells function experiments, mainly including CCK-8 assess viability, flow cytometry examine apoptosis, Western blotting measure Janus kinase (JAK)/signal transducers activators transcription 3 (STAT3) pathway protein expression. Furthermore, JAK/STAT3 knockdown blocking effect on was also assessed.Co-treatment increased AML AraC. Also, it effectively reversed shown significantly reduced proliferation apoptosis rates. suppressed activation signaling cells, suggesting reversing indeed dependent pathway.In summary, enhanced AML/AraC-resistant modulating pathway.

Language: Английский

Citations

4