Journal of Biomedical Materials Research Part A,
Journal Year:
2019,
Volume and Issue:
108(1), P. 61 - 68
Published: Aug. 26, 2019
Immune
response
to
implantation
materials
plays
a
critical
role
during
early
local
inflammation
and
biomaterial-induced
regeneration
or
restoration.
A
novel
platelet
concentrate
termed
i-PRF
(injectable
platelet-rich
fibrin)
has
recently
been
developed
without
any
additives
by
low
centrifugation
speeds.
To
date,
scientists
have
investigated
the
capability
of
releasing
growth
factors
improve
but
ignored
whether
can
inhibit
inflammatory
effect
around
wound.
The
present
study
anti-inflammation
effects
on
immune
response-related
cells,
especially
macrophages
dendric
cells.
We
found
that
reduced
pro-inflammatory
M1
phenotype
activated
dendritic
cells
muscle
defect
was
injected
with
bacterial
suspension.
Moreover,
in
vitro
experiments
showed
similar
results.
deleted
caused
lipopolysaccharide
some
extent.
determined
TLR4,
an
activator
stimulation
p-p65,
key
factor
belongs
classical
related
NF-κB
signal
pathway,
be
inhibited
use
i-PRF.
Results
indicate
potential
anti-inflammatory
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6319 - 6319
Published: June 7, 2024
The
gold
standard
in
the
non-surgical
treatment
of
periodontitis
is
scaling
and
root
planing
(SRP).
In
recent
years,
use
autogenous
platelet
concentrates
has
spread
over
many
specialties
dentistry
and,
thus,
also
been
gaining
popularity
periodontal
treatment.
Its
two
main
fractions
are
platelet-rich
plasma
(PRP)
fibrin
(PRF),
which,
since
2014,
can
be
used
via
injection
as
injectable
(i-PRF).
authors
conducted
a
comprehensive
systematic
review
accordance
with
PRISMA
2020
guidelines.
It
involved
searching
PubMed,
Embase,
Scopus,
Google
Scholar
databases
using
phrases
(“Root
Planing”
OR
“Subgingival
Curettage”
“Periodontal
Debridement”)
AND
(“Platelet-Rich
Plasma”).
Based
on
authors’
inclusion
exclusion
criteria,
12
results
were
included
review,
out
1170
total
results.
objective
this
was
to
ascertain
impact
utilizing
PRP
i-PRF
SRP.
revealed
that
both
incorporation
found
significantly
associated
duction
gingival
pocket
depth
again
clinical
attachment
level;
however,
demonstrated
superiority
improving
parameters.
Furthermore,
notable
bactericidal
efficacy
against
Porphyromonas
gingivalis.
On
other
hand,
proved
inferior
an
Nd:YAG
laser
parameter
improvement;
it
significant
efficiency
well.
This
literature
led
conclusion
autologous
might
competent
agents
for
therapeutic
outcomes
BMC Oral Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 9, 2025
Abstract
Objectives
This
randomized
prospective
controlled
trial
investigated
the
effectiveness
of
different
strategies
regenerative
endodontic
therapy
on
necrotic
mature
anterior
teeth
with
chronic
periapical
periodontitis
18
months
follow
up.
Methods
A
total
analyzed
51
adult
participant
single
rooted
having
pulp
(PAI
≥
3)
were
selected.
Patients
had
been
randomly
categorized
into
three
distinct
groups
(
n
=
17
each
group).
All
received
same
treatment
first
visit.
After
2
weeks,
was
performed
using
either
blood
clot
technique,
Standard-PRF
and
Advanced-PRF
approach.
standardized
radiograph
taken,
patients
instructed
for
6,
12
up
periods.
Fisher's
exact
test
applied
to
compare
frequency
PAI
scores
at
follow-up
intervals
between
groups.
Results
The
results
showed
radiographic
success
(58.8%
in
group,
94.1%
S-PRF
group
76.5%
A-PRF
There
no
statistically
significant
difference
according
incidence
healing
months.
Clinical
82.4%
88.2%
both
p
1).
overall
(clinical
radigraphic)
76.5%.
Incidence
gaining
sensitivity
after
29.4%
41.2%
within
17.6%
BC
group.
Conclusion
PRF
based
technique
may
outperform
non-vital
periodontitis.
is
a
need
future
clinical
studies
consolidate
procedures
this
field
more
prolonged
evaluation
registration
study
retrospectively
registered
ClinicalTrials.gov
(ID:
NCT04606719
)
28/10/2020.
Platelets,
Journal Year:
2017,
Volume and Issue:
30(2), P. 213 - 221
Published: Dec. 14, 2017
The
aim
of
the
present
study
was
to
evaluate
effect
injectable
platelet-rich
fibrin
(i-PRF)
on
cultivated
chondrocytes
and
osteochondral
regeneration
in
critical-sized
defect
rabbit's
knee
comparison
autologous
plasma
(PRP).
Chondrocytes
were
first
investigated
for
their
ability
proliferate
differentiate
response
PRP
i-PRF.
Thereafter,
full-thickness
defects
5
mm
diameter
depth
created
joint
12
adult
female
New
Zealand
White
rabbits.
Defects
regenerated
with
either
or
i-PRF
compared
control.
Animals
sacrificed
at
4
weeks
postoperatively
evaluated
histologically
by
macroscopic
microscopic
examination
cartilage
regeneration.
significantly
promoted
chondrocyte
proliferation
mRNA
levels
Sox9,
collagen
type
II,
aggrecan
when
Histological
analysis
revealed
that
weeks,
ICRS
scores
from
group
enhanced
control
groups.
At
post
surgery,
demonstrated
improved
PRP.
In
conclusion,
use
using
low
speed
centrifugation
concept
activity
further
histological
results
early
better
within
utilized
maintained
weeks.
Future
clinical
studies
are
now
needed
investigating
regenerative
potential
Clinical Implant Dentistry and Related Research,
Journal Year:
2018,
Volume and Issue:
20(5), P. 703 - 712
Published: Aug. 17, 2018
Abstract
Background
Platelet
concentration
based
membranes,
as
well
collagen
membranes
in
combination
with
bone
substitutes,
have
demonstrated
successful
outcomes
regeneration
of
peri‐implant
defects
(PBD).
Purpose
The
aim
this
study
was
to
evaluate
the
clinical
and
radiographic
regenerative
surgical
treatment
(RST)
peri‐implantitis
using
a
substitute
combined
two
different
bioresorbable
barrier
either
membrane
(CM)
or
concentrated
growth
factor
(CGF),
during
12‐month
follow‐up.
Materials
Methods
Fifty
patients,
who
had
at
least
one
lesion
treated
by
CGF
CM.
After
procedures,
implants
were
allowed
for
submerged
healing.
Clinical
assessments
conducted
baseline,
6
12
months
postoperatively,
while
evaluation
performed
baseline
months.
Results
Significant
reductions
obtained
mean
gingival
index
(GI),
bleeding
on
probing
(BOP),
depth
(PD),
attachment
level
(CAL)
mucosal
recession
(MR)
values
both
postoperatively
compared
procedures
(
P
<
0.05).
At
months,
no
statistically
significant
difference
observed
all
parameters
between
groups,
whereas
PD,
CAL
vertical
defect
(VDD)
favor
CM
group
fill
(DF)
(1.99
±0.76)
not
significantly
from
that
CCF
(1.63
±1.00)
=
0.154).
Conclusions
present
suggest
approaches
yielded
improvements
assessments.
procedure
showed
better
results
RST
peri‐implantitis.
Journal of Biomedical Materials Research Part A,
Journal Year:
2019,
Volume and Issue:
108(1), P. 61 - 68
Published: Aug. 26, 2019
Immune
response
to
implantation
materials
plays
a
critical
role
during
early
local
inflammation
and
biomaterial-induced
regeneration
or
restoration.
A
novel
platelet
concentrate
termed
i-PRF
(injectable
platelet-rich
fibrin)
has
recently
been
developed
without
any
additives
by
low
centrifugation
speeds.
To
date,
scientists
have
investigated
the
capability
of
releasing
growth
factors
improve
but
ignored
whether
can
inhibit
inflammatory
effect
around
wound.
The
present
study
anti-inflammation
effects
on
immune
response-related
cells,
especially
macrophages
dendric
cells.
We
found
that
reduced
pro-inflammatory
M1
phenotype
activated
dendritic
cells
muscle
defect
was
injected
with
bacterial
suspension.
Moreover,
in
vitro
experiments
showed
similar
results.
deleted
caused
lipopolysaccharide
some
extent.
determined
TLR4,
an
activator
stimulation
p-p65,
key
factor
belongs
classical
related
NF-κB
signal
pathway,
be
inhibited
use
i-PRF.
Results
indicate
potential
anti-inflammatory
