Subgingival Delivery of Statins as an Adjunct in the Non-Surgical Treatment of Periodontitis: A Systematic Review

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 182 - 182

Published: Jan. 13, 2025

Background/Objectives: The gold standard in the non-surgical treatment of periodontitis is scaling and root planning (SRP). In recent years, studies have emerged suggesting additional clinical benefits from use statins as an adjunct to classical periodontal disease treatment. aim present study was review relevant literature relating subgingival adjunctive classical, periodontitis, with a particular focus on groups general factors that may affect outcome Methods: authors conducted systematic following PRISMA 2020 guidelines. electronic search included MEDLINE (PubMed) database, Web Science, Scopus, Google Scholar 1 January 2012 14 June 2024. keywords used for PubMed were determined help MeSH Browser Tool follows: Periodontitis [Mesh] AND Statin OR Simvastatin Atorvastatin or Rosuvastatin Calcium [Mesh]. Based authors’ inclusion exclusion criteria, 20 results review, out 937. Results: improvement more pronounced patients without diseases compared those type II diabetes non-smokers smoking patients. Greater improvements radiological parameters seen diagnosed aggressive chronic periodontitis. Conclusions: This led conclusion applied locally might be competent agents improving therapeutic outcomes SRP.

Language: Английский

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Antibiotic-Loaded Platelet-Rich Fibrin (AL-PRF) as a New Carrier for Antimicrobials: A Systematic Review of In Vitro Studies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2140 - 2140

Published: Feb. 27, 2025

Platelet-rich fibrin (PRF) has emerged as a promising scaffold for drug delivery, particularly in the context of antimicrobial therapies. This systematic review evaluates incorporation antibiotics into PRF to determine its efficacy localized delivery system compared plain without antibiotics. A was conducted according Preferred Reporting Items Systematic Reviews and Meta-Analyses (PRISMA) guidelines, including 13 vitro studies with moderate risk bias. Antibiotics were incorporated using different methodologies, systemic administration before blood collection, addition centrifugation, injection formed matrices. Outcomes analyzed regarding antibacterial efficacy, structural integrity PRF, release kinetics. Antibiotic-enhanced demonstrated significant activity against various bacterial strains. The enhanced dependent on type antibiotic, concentration, method. Encapsulation approaches facilitated sustained antibiotic release, while higher concentrations occasionally disrupted integrity. Systemic collection enriches effectively, producing inhibition zones. effects outperformed alternative carriers, such collagen sponges. Antibiotic-loaded is potent tool applications clinical settings. Further research needed standardize preparation protocols explore impact methods PRF's regenerative properties.

Language: Английский

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The Use of Hyaluronic Acid in the Non-Surgical Treatment of Periodontitis—An Umbrella Review

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 998 - 998

Published: April 20, 2025

Background: Periodontitis is a prevalent inflammatory condition that destroys periodontal tissues. Scaling and root planing (SRP) the gold standard for non-surgical treatment; however, its efficacy may be limited in cases with complex dental issues. This umbrella review aims to evaluate effectiveness of hyaluronic acid (HA) as an adjunct scaling enhancing clinical outcomes periodontitis management. Methods: A comprehensive five systematic reviews, including meta-analyses where available, was conducted synthesize evidence on adjunctive use HA SRP. The studies were evaluated using AMSTAR-2 quality assessment tool determine methodological rigor. Data parameters such probing depth (PD), attachment level (CAL), bleeding (BOP), gingival index (GI), plaque (PI) extracted analyzed. Results: findings indicate supplementation leads moderate improvements PD, CAL, BOP, GI, PI compared SRP alone. Notable reductions PD gains CAL observed, some showing statistically significant benefits. However, heterogeneity concentrations (0.2–1.4%), application methods, treatment frequencies, follow-up durations (1 week 12 months) limits definitive conclusions. Additionally, did not significantly affect reduction P. gingivalis prevalence. Conclusions: conjunction shows promise therapy. methodologies indicates necessity high-quality, standardized randomized controlled trials establish clear guidelines periodontitis.

Language: Английский

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Gingival Augmentation Using Injectable Platelet-Rich Fibrin (i-PRF)—A Systematic Review of Randomized Controlled Trials

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(18), P. 5591 - 5591

Published: Sept. 20, 2024

Background: In recent years, the utilization of blood concentrates in dentistry has become increasingly prevalent. 2014, development injectable platelet-rich fibrin (i-PRF) was achieved. One key benefits i-PRF is its ability to consistently release a range growth factors. This review aimed determine whether could be used for gingival augmentation. Methods: The research involved search PubMed, Embase, Scopus, and Google Scholar databases using following terms: (“microneedling” or “micro needling” “injectable fibrin” “i-PRF”) (“gingival augmentation” “augmentation” “attached gingiva” mucosa” “soft tissue “KM” “keratinized mucosa”). Results: Of 668 results, 8 articles meeting inclusion criteria were included article. results studies analyzed indicated significant increase thickness. Furthermore, some demonstrated an keratinized width. augmentation thickness with yielded no inferior comparison free graft, which current gold standard, resulting superior aesthetic outcome reduction postoperative discomfort. Conclusions: systematic allowed authors conclude that use hyaluronic acid may first step towards developing non-surgical method

Language: Английский

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How to Deal with Pulpitis: An Overview of New Approaches

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(1), P. 25 - 25

Published: Jan. 8, 2025

Background: Traditional root canal therapy (RCT) effectively removes diseased or necrotic pulp tissue and replaces it with inorganic materials. Regenerative endodontics is an alternative to conventional RCT by using biologically based approaches restore the pulp-dentin complex. This review explores emerging techniques, including autogenic allogenic transplantation, platelet-rich fibrin, human amniotic membrane scaffolds, specialized pro-resolving mediators, nanofibrous bioceramic injectable hydrogels, dentin matrix proteins, cell-homing strategies. These methods utilize stem cells, growth factors, biomaterials regenerate vascularized, functional tissue. Methods: A narrative was conducted PubMed, Scopus, Embase identify studies published between 2010 2023. In vitro, animal, clinical focusing on innovative regenerative endodontic techniques were analyzed. Conclusions: Although demonstrates great potential, challenges remain in standardizing protocols, addressing biological variability, achieving consistent outcomes. Future research must focus refining these ensure their safety, efficacy, accessibility routine practice. By current limitations, could redefine management of pulpitis, offering treatments that enhance tooth vitality, structural integrity, long-term prognosis.

Language: Английский

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Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 35 - 35

Published: Jan. 9, 2025

Periodontitis, a chronic multifactorial inflammatory condition of the periodontium, is originated by dysbiotic oral microbiota and negatively correlated with several systemic diseases. The low-chronic burden gingival inflammation not only exacerbates periodontitis but also predisposes individuals to spectrum age-related conditions, including cardiovascular diseases, neurodegenerative disorders, metabolic dysfunction, especially related ageing. In this regard, over local periodontal treatment, lifestyle modifications adjunctive therapies may offer synergistic benefits in ameliorating both health ageing populations. Elucidating intricate connections between senescence important for understanding health's implications Effective management strategies targeting senescent pathways novel avenues promoting healthy preventing morbidities. This review will analyze current literature about interplay periodontitis, dysbiosis, processes senescence, shedding light on their collective impact modulation accelerated Lastly, therapeutic dysbiosis mitigate its associated morbidities be discussed.

Language: Английский

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Clinical Performance of the Bioperio® Protocol to Manage Periodontitis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1738 - 1738

Published: March 4, 2025

Objectives: The aim of this study was to describe the structure and assess efficacy a patient-centered framework for managing periodontitis, utilizing Bioperio® protocol, standardized treatment approach incorporating both clinical extra-clinical phases. Methods: Patients diagnosed with periodontitis were included in multicenter, single-arm, observational 3-month follow-up. All patients treated following involving professional supra-gingival scaling, oral hygiene instructions, scaling root planing full-mouth approach. In Stage III/IV cases, enamel matrix derivatives (EMD) applied periodontal pockets > 5 mm. Monthly recalls performed until Results: total, 663 enrolled, 76.4% being II/III periodontitis. At 3 months, all parameters improved regardless initial stage achieving pocket closure 75.4% cases patient resolution 91.3% sample. Stages I/II showed significantly outcomes compared IV. adjunct EMDproved beneficial, especially III patients, increasing by 15% doubling odds resolution. No adverse effects protocol observed throughout study. Conclusions: appears be safe effective therapeutic management affected Combining stepwise phases tailored instructions motivational sessions offers comprehensive strategy that may enhance

Language: Английский

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Use of amniotic membranes in dentistry – literature review

Polski Merkuriusz Lekarski, Journal Year: 2025, Volume and Issue: 53(1), P. 115 - 119

Published: Jan. 1, 2025

The amniotic membrane, which lacks blood vessels, lymphatic vessels and nerves, is a thin membrane with anti-inflammatory anti-scarring properties. In the field of dentistry, it primarily employed as dressing following removal malignant or pre-malignant lesions, objective ensuring haemostasis absence allergic reactions. Furthermore, in treatment oro-auricular junctions, cleft palates guided bone regeneration, due to presence mesenchymal cells. vestibuloplasty, has been demonstrated enhance vestibular deepening, accelerate epithelialisation reduce pain. periodontics, shown be an effective for gingival recession furcation defects, increase width keratinised gingiva around implants. endodontics, regenerative procedures, offering comparable results standard methods. osteoarthritis temporomandibular joint, observed provide pain relief improved joint function.

Language: Английский

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Comparative analysis of cytokine profiles in canine injectable platelet-rich fibrin and platelet-rich plasma

International Journal of Veterinary Science and Medicine, Journal Year: 2025, Volume and Issue: 13(1), P. 1 - 8

Published: April 3, 2025

This study compared injectable platelet-rich fibrin (i-PRF) and plasma (PRP) derived from canine blood, focusing on their cellular content cytokine profiles to evaluate suitability for various veterinary clinical applications. Blood samples were collected 20 client-owned dogs. i-PRF PRP prepared using low-speed centrifugation double methods, respectively. cell counts quantified automated analysers, while growth factors cytokines measured a Luminex assay. The results showed that both significantly reduced red blood with whole blood. achieved 3.81-fold increase in the platelet concentration higher than 1.89-fold by i-PRF. also contained levels of white cells, particularly lymphocytes monocytes. Growth factor between two products unexpectedly similar. In conclusion, demonstrated superior concentrations i-PRF, its preparation process was more complex time-consuming. Conversely, offered advantages shorter time absence anticoagulants, making it potentially suitable certain applications despite similarity products.

Language: Английский

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Comparative Evaluation of Platelet-Rich Fibrin (PRF) and Concentrated Growth Factor (CGF) as Carriers for Antibiotics—In Vitro Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4303 - 4303

Published: May 1, 2025

The rising prevalence of antibiotic resistance underscores the need for localized drug delivery systems that minimize systemic exposure. Autologous platelet concentrates (APCs), including concentrated platelet-rich fibrin (c-PRF) and liquid-phase growth factors (LPCGFs), have emerged as potential carriers antimicrobial agents. This study aimed to evaluate efficacy c-PRF LPCGF three formulations-amoxicillin with clavulanic acid, clindamycin, a combination amoxicillin metronidazole-against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant (MRSA), Enterococcus faecalis (low-level natural resistance). disk diffusion method was employed incorporate antibiotics into both APC types, which were then applied disks placed on bacterial cultures. size inhibition zones measured at 20-, 40-, 60-, 80-h intervals. Every 20 h, transferred new Petri dish. Statistical analysis included Welch's t-test two-way ANOVA. demonstrated superior performance carrier showing presence up 60 h. In contrast, exhibited greater when used amoxicillin-metronidazole combination, particularly higher concentrations. Both APCs showed limited effectiveness against E. combined clindamycin. confirms suitability autologous systems. choice between should be guided by drug's physicochemical properties clinical application. offer promising alternative targeted therapy in dental surgical settings.

Language: Английский

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