The clinical efficacy of injectable platelet-rich fibrin (i-PRF) as an adjunct to nonsurgical periodontal therapy in smokers with periodontitis DOI Creative Commons
Taşkın Gürbüz,

Bilge Meracı Yıldıran

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Smokers with periodontitis generally respond less favorably to nonsurgical treatments compared nonsmokers. Injectable platelet-rich fibrin (i-PRF) is an effective autogenous material that positively influences various biological processes, including inflammation, wound healing, angiogenesis, and regeneration. This split-mouth randomized controlled study aims investigate the effects of subgingival i-PRF application on clinical periodontal parameters as adjunct scaling root planning (SRP) in smokers periodontitis. included twenty-five patients Stage 2 3 Grade C For each patient, four contralateral deep pockets (two for side) were randomly treated SRP + (test group) or saline (control group). Subgingival i-PRF/saline was repeated 7th day, recorded at baseline 1 months following treatments. Compared measurements, both groups presented significant improvements parameters. The probing depth (PD) significantly lower test group than control 1st 3rd (P < 0.05). 3-month gingival index (GI) bleeding (BOP) values No differences observed Turesky modified Quigley-Hein Plaque Index (TQHPI) attachment loss (CAL) score between during follow-up visits > However, greater PD reduction gain found Greater indicate may play a beneficial role improving outcomes treatment ID NCT06605547 ( https://clinicaltrials.gov/ ); September 23, 2024.

Language: Английский

Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis DOI Creative Commons
Richard J. Miron, Vittório Moraschini, Masako Fujioka‐Kobayashi

et al.

Clinical Oral Investigations, Journal Year: 2021, Volume and Issue: 25(5), P. 2461 - 2478

Published: Feb. 20, 2021

Abstract Objectives This study aims to compare the treatment outcomes of periodontal intrabony defects by using platelet-rich fibrin (PRF) with other commonly utilized modalities. Materials and methods The eligibility criteria comprised randomized controlled trials (RCTs) comparing clinical PRF that Studies were classified into 10 categories as follows: (1) open flap debridement (OFD) alone versus OFD/PRF; (2) OFD/bone graft (OFD/BG) (3) OFD/BG OFD/BG/PRF; (4–6) OFD/barrier membrane (BM), OFD/PRP, or OFD/enamel matrix derivative (EMD) (7) OFD/EMD OFD/EMD/PRF; (8–10) OFD/PRF OFD/PRF/metformin, OFD/PRF/bisphosphonates, OFD/PRF/statins. Weighted means forest plots calculated for probing depth (PD), attachment level (CAL), radiographic bone fill (RBF). Results From 551 articles identified, 27 RCTs included. use statistically significantly reduced PD improved CAL RBF when compared OFD. No clinically significant differences reported was OFD/PRF. addition led improvements in RBF. between any following groups (OFD/BM, OFD/EMD) also added OFD/EMD. all three biomolecules (metformin, bisphosphonates, statins) PD, CAL, Conclusions OFD similar levels being observed Future research geared toward better understanding potential ways enhance regenerative properties various small may prove valuable future applications. investigating at histological is needed. Clinical relevance conjunction values, yielding comparable OFD/BG. combination grafts offer certain advantages, thus warranting further investigations.

Language: Английский

Citations

133
Gelatin Nanoparticle‐Injectable Platelet‐Rich Fibrin Double Network Hydrogels with Local Adaptability and Bioactivity for Enhanced Osteogenesis DOI

Zhixiang Mu,

Kaiwen Chen, Shuai Yuan

et al.

Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 9(5)

Published: Jan. 29, 2020

Bone healing is a dynamic process regulated by biochemical signals such as chemokines and growth factors, biophysical topographical mechanical features of extracellular matrix or stimuli. Hereby, mechanically tough bioactive hydrogel based on autologous injectable platelet-rich fibrin (iPRF) modified with gelatin nanoparticles (GNPs) developed. This composite demonstrates double network (DN) mechanism, wherein covalent serves to maintain material integrity, self-assembled colloidal GNPs dissipates force upon loading. A rabbit sinus augmentation model used investigate the bioactivity osteogenesis capacity DN hydrogels. The hydrogels adapt local environmental complexity bone defects, i.e., accommodate irregular shape defects withstand pressure formed in maxillary during animal's respiration process. also demonstrated absorb prolong release factors stemming from iPRF, which could have contributed early angiogenesis observed inside sinus. adaptable can achieve enhanced regeneration treating complex maintaining long-term mass withstanding functional

Language: Английский

Citations

82
Injectable Platelet‐Rich Fibrin (PRF): The newest biomaterial and its use in various dermatological conditions in our practice: A case series DOI
Shashank Bansod,

Madke Bhushan

Journal of Cosmetic Dermatology, Journal Year: 2020, Volume and Issue: 20(5), P. 1421 - 1426

Published: Sept. 30, 2020

Abstract Injectable platelet‐rich fibrin (I‐PRF) is a second generation, fully autologous, blood‐derived biomaterial having three‐dimensional meshwork, like that of PRF clot, while retaining the fluid nature, just plasma (PRP). Along with platelets and its growth factors, injectable predominantly has collagen type‐1, lymphocytes along factors. Preparation simple requires minimal instrumentation materials, making it cost‐effective product. We have been trying using this in conditions where PRP clot are being used currently, androgenetic alopecia, periorbital rejuvenation, temporary filler material as an agent to promote wound healing favorable results.

Language: Английский

Citations

74
The application of injectable platelet-rich fibrin in regenerative dentistry: A systematic scoping review of In vitro and In vivo studies DOI Creative Commons
Nima Farshidfar,

Dana Jafarpour,

Parsa Firoozi

et al.

Japanese Dental Science Review, Journal Year: 2022, Volume and Issue: 58, P. 89 - 123

Published: March 29, 2022

Ongoing research in the dental field has begun to focus on use of injectable platelet-rich fibrin (I-PRF) as a regenerative tool with potential prompt tissue regeneration. In this regard, systematic scoping review aimed collect, map, and appraise vitro vivo studies regarding role I-PRF or soft hard regeneration relation oral maxillofacial structures. A electronic search Medline, Scopus, Web Science, Embase databases was performed from 2000 December 2021 using combination keywords. All studies, written English concerning dentistry were considered. total, 18 5 animal 6 case reports, 31 clinical have evaluated effect The investigated verified anti-inflammatory, anti-microbial efficacy positive effects application for wound, periodontal, bone, cartilage, pulp regeneration, well acceleration tooth movement during orthodontic treatment. Current literature approves feasibility promising adjunct procedures.

Language: Английский

Citations

51
Efficacy of biologics for the treatment of periodontal infrabony defects: An American Academy of Periodontology best evidence systematic review and network meta‐analysis DOI
Lorenzo Tavelli, Chia‐Yu Chen, Shayan Barootchi

et al.

Journal of Periodontology, Journal Year: 2022, Volume and Issue: 93(12), P. 1803 - 1826

Published: Oct. 24, 2022

Abstract Background A large variety of biomaterials, biologics and membranes have been utilized in the past 40 years for regenerative treatment periodontal infrabony defects. Biologic agents progressively gained popularity among clinicians are routinely used regeneration. In alignment with goals American Academy Periodontology (AAP) Best Evidence Consensus (BEC) on use biologic mediators contemporary clinical practice, aim this sytematic review was to evaluate effect agents, specifically autogenous blood‐dervied products (ABPs), enamel matrix derivative (EMD) recombinant human platelet‐derived growth factor‐BB (rhPDGF‐BB), outcomes Methods detailed systematic search conducted identify eligible randomized control trials (RCTs) reporting therapy using frequentist mixed‐modeling approach network meta‐analysis (NMA), characterized by assessment three individual components an defect (the bone graft material [BG], agent, application a barrier membrane) performed compare relative efficacy different components, therapeutic modalities Results total 153 RCTs were included, 150 studies contributing NMA. The quantitative analysis showed that addition significantly improves radiographic outcomes, as compared BG flap procedures alone. Barrier enhanced but did not provide further benefits combination biologics. type (autogenous, allogeneic, xenogeneic or alloplastic) agent (EMD, platelet‐rich fibrin [PRF], plasma [PRP] rhPDGF‐BB) played significant role final Allogeneic BGs exhibited statistically superior gain than synthetic (p < 0.05 all comparisons), while rhPDGF‐BB PRF demonstrated higher stability gingival margin 0.01) fill/gain 0.05), together greater, although significant, attachment level pocket depth reduction, EMD PRP. Overall, largest size most parameters, including gain, less recession linear gain. Considering relatively high number presenting unclear risk bias, strength recommendation supporting PRP judged weak, EMD, deemed favor. Conclusions Biologics enhance therapy. Combination therapies involving + membrane be monotherapies. choice seems impact

Language: Английский

Citations

39
Ten years of injectable platelet‐rich fibrin DOI Creative Commons
Richard J. Miron, Reinhard Gruber, Nima Farshidfar

et al.

Periodontology 2000, Journal Year: 2023, Volume and Issue: 94(1), P. 92 - 113

Published: Nov. 30, 2023

Abstract The use of platelet‐rich fibrin (PRF) has seen widespread advantages over plasma (PRP) in many fields medicine. However, until 2014, PRF remained clinically available only its solid clotted form. Modifications to centrifugation protocols and tube technology have led the development a liquid injectable version (i‐PRF). This narrative review takes look back at technological developments made throughout past decade further elaborates on their future clinical applications. Topics covered include improvements isolation techniques protocols, ways concentrate i‐PRF, impact relevance cooling i‐PRF. Next, various uses i‐PRF are discussed, including regenerative periodontology, implantology, endodontics, temporomandibular joint injections, orthodontic tooth movement. Furthermore, indications medicine also covered, sports injuries osteoarthritis joints, treatment diabetic ulcers/wound care, facial esthetics hair regrowth. Finally, applications mainly as drug delivery vehicle for small biomolecules, such growth factors, antibiotics, exosomes, other medications that may benefit from controlled gradual release biomolecules time.

Language: Английский

Citations

27
Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization DOI Creative Commons

Kewen Jia,

Jiaqian You, Yuemeng Zhu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 16, 2024

Platelet-rich fibrin, a classical autologous-derived bioactive material, consists of fibrin scaffold and its internal loading growth factors, platelets, leukocytes, with the gradual degradation slow release physiological doses factors. PRF promotes vascular regeneration, proliferation migration osteoblast-related cells such as mesenchymal cells, osteoblasts, osteoclasts while having certain immunomodulatory anti-bacterial effects. has excellent osteogenic potential been widely used in field bone tissue engineering dentistry. However, there are still some limitations PRF, improvement biological properties is one most important issues to be solved. Therefore, it often combined scaffolds enhance mechanical delay degradation. In this paper, we present systematic review development platelet-rich derivatives, structure mechanisms, applications, optimization broaden their clinical applications provide guidance for translation.

Language: Английский

Citations

12
How to explain the beneficial effects of leukocyte‐ and platelet‐rich fibrin DOI Creative Commons
Juan Blanco, Ángel Galindo García, Lidia Hermida‐Nogueira

et al.

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

The survival of an organism relies on its ability to repair the damage caused by trauma, toxic agents, and inflammation. This process involving cell proliferation differentiation is driven several growth factors critically dependent organization extracellular matrix. Since autologous platelet concentrates (APCs) are fibrin matrices in which cells, factors, cytokines trapped delivered over time, they able influence that response at different levels. present review thoroughly describes molecular components one these APCs, leukocyte- platelet-rich (L-PRF), summarizes level evidence regarding L-PRF anti-inflammatory reactions, analgesia, hemostasis, antimicrobial capacity, biological mechanisms bone/soft tissue regeneration.

Language: Английский

Citations

9
Autologous platelet concentrates as adjuncts to non-surgical periodontal therapy: a systematic review and meta-analysis DOI Creative Commons

Tina Lipovec,

Nirav S. Kapadia, Georgios N. Antonoglou

et al.

Clinical Oral Investigations, Journal Year: 2025, Volume and Issue: 29(1)

Published: Jan. 22, 2025

Abstract Objective To evaluate the possible additional clinical benefit from autologous platelet concentrate (APC) treatment adjunct to non-surgical periodontal therapy (NSPT). Methods Electronic (MEDLINE/Embase/Cochrane/MedNar/CORE) and hand searches were conducted. Following studies selection, evidence tables formed, meta-analyses performed for following outcomes: probing pocket depth (PPD) reduction, attachment level (CAL) gain, bleeding on (BoP) reduction. The protocol this systematic review was registered in PROSPERO (CRD42023514388). Results After de-duplication, initial search yielded 194 citations, which ten papers eligible quantitative synthesis. APC group comprised 270 patients, while control included 230. meta-analysis revealed that a single application resulted 0.6 mm greater PPD reduction (MD = -0.62; 95% CI: -1.03, -0.22) 0.8 more CAL gain -0.77; -1.18, -0.37) at 6–12 weeks follow-up. At six months, exhibited -0.61; -1.13, -0.09) 1.1 -1.14; -1.94, -0.34) compared NSPT only group. In contrast, BoP indices did not reveal statistically significant difference between groups after -10.54; -25.21, 4.14). High heterogeneity unclear high risk of bias detected. Conclusion Over adjunctive use appears provide benefits alone. Clinical relevance APCs seems promote further improvements outcomes NSPT.

Language: Английский

Citations

1
Utilizing 3D bioprinted platelet-rich fibrin-based materials to promote the regeneration of oral soft tissue DOI Creative Commons
Ke Yi, Qing Li, Xiaodong Lian

et al.

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 1, 2022

Oral soft tissue defects remain difficult to treat owing the limited efficacy of available treatment materials. Although injectable platelet-rich fibrin (i-PRF) is a safe, autologous source high levels growth factors that often employed promote regeneration oral tissue, its effectiveness restrained by difficulties in intraoperative shaping together with burst-like release factors. We herein sought develop bioactive bioink composed i-PRF, alginate and gelatin capable promoting tissue. This was successfully applied 3D bioprinting exhibited ability be shaped individual patient needs. Importantly, we were also able significantly prolong duration multiple as compared observed for i-PRF. The factor bioavailability further confirmed enhanced proliferation viability printed gingival fibroblasts. When deployed vivo nude mice, this biocompatible drive angiogenic activity. Together, these data thus confirm successful production an i-PRF-containing bioink, which suitable individualized promotion

Language: Английский

Citations

36