Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(11), P. 1053 - 1067
Published: Aug. 30, 2023
COVID-19 is associated with a range of neurological, cognitive, and mental health symptoms both acutely chronically that can persist for many months after infection in people long-COVID syndrome. Investigations cognitive function neuroimaging have begun to elucidate the nature some these symptoms. They reveal that, although deficits may be related brain imaging abnormalities people, also occur absence objective or changes. Furthermore, impairment detected even asymptomatic individuals. We consider evidence regarding symptoms, deficits, neuroimaging, as well their possible underlying mechanisms.
Language: Английский
Citations
40
Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15
Published: April 4, 2024
Corona Virus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has presented unprecedented challenges to world. Changes after COVID-19 have had a significant impact on patients with neurodegenerative diseases. This study aims explore mechanism of diseases examining main pathways central nervous system infection SARS-CoV-2. Research indicated that chronic inflammation and abnormal immune response are primary factors leading neuronal damage long-term consequences COVID-19. In some patients, concurrent inflammatory leads increased release pro-inflammatory cytokines, which may significantly prognosis. Molecular imaging can accurately assess severity in phase. Furthermore, use FDG-PET is advocated quantify relationship between neuroinflammation psychiatric cognitive symptoms who recovered from Future development should focus aggressive post-infection control targeted therapies target ACE2 receptors, ERK1/2, Ca 2+ .
Language: Английский
Citations
10
Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(4), P. 1325 - 1333
Published: Jan. 9, 2024
Language: Английский
Citations
6
Clinical Neurophysiology, Journal Year: 2024, Volume and Issue: 161, P. 159 - 172
Published: March 6, 2024
Several persons experiencing post-covid-19 (post-COVID) with "brain fog" (e.g., fatigue, cognitive and psychiatric disorders, etc.) show abnormal resting-state electroencephalographic (rsEEG) rhythms reflecting a vigilance dysfunction. Here, we tested the hypothesis that in those post-COVID persons, rsEEG may occur even when disorders are absent. The experiments were performed on participants about one year after hospitalization for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Inclusion criteria included claim, no pre-infection, actual organic chronic disease. Matched controls (no COVID) also enrolled. All underwent clinical/neuropsychological assessment (including fatigue assessment) recordings. eLORETA freeware estimated regional cortical sources at individual delta (< 4 Hz), theta (4-7 alpha (8-13 Hz) bands. Beta (14-30 gamma (30-40 bands pre-fixed. More than 90% of all showed or 75% ≥ symptoms. group globally presented lower posterior source activities Control group. This effect was more significant long COVID-19 patients In diseases cognitive/psychiatric can be associated subjective fatigue. These abnormalities related to allostatic dysfunctions.
Language: Английский
Citations
5
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 293 - 293
Published: March 20, 2024
Neurological involvement following coronavirus disease 19 (COVID-19) is thought to have a neuroinflammatory etiology. Co-ultraPEALut (an anti-inflammatory molecule) and luteolin anti-oxidant) shown promising results as neuroinflammation antagonists. The aim of this study was describe cognitive impairment in patients with post-COVID-19 treated co-ultraPEALut. Montreal Cognitive Assessment (MoCA), the Prospective–Retrospective Memory Questionnaire (PRMQ), Fatigue Severity Scale (FSS), subjective assessment were administered at baseline after 10 months. Patients co-ultraPEALut retrospectively compared controls. Twenty-six showed significant improvement PRMQ (T0: 51.94 ± 10.55, T1: 39.67 13.02, p < 0.00001) MoCA raw score 25.76 2.3, 27.2 2, 0.0260); MoCA-adjusted FSS questionnaires also an improvement, even though it not statistically significant; 80.77% reported improvement. In control subjects (n = 15), pronounced (PRMQ T0: 45.77 13.47, 42.33 16.86, 0.2051; 4.95 1.57, 4.06 1.47, 0.1352). corticosteroids different from those alone. Neuro-post-COVID-19 scored better than controls months: may support importance modulation for neuro-long-COVID-19.
Language: Английский
Citations
5
Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(9), P. 531 - 538
Published: July 25, 2023
Language: Английский
Citations
13
Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(5)
Published: May 20, 2024
Background: Long-Covid, characterized by persistent symptoms following acute Covid-19 infection, represents a complex challenge for the scientific community. Among most common and debilitating manifestations, cognitive fog is neurological disorder mental confusion difficulties. In this study, we investigated long-term effects of previous infection on cortical brain activity in patients experiencing medium long term. Methods: A total 40 subjects (20 females 20 males) aged between 45 70 years (mean age (M) = 59.78, standard deviation (SD) 12.93) participated study. This sample included individuals with fog, both without anosmia, control group comprised healthy subjects. All electroencephalography (EEG) data were collected two sessions, 1 month 8 months after recovery from Covid-19, to measure neurophysiological parameters P300 beta band rhythms. Results: The results revealed significant differences rhythms affected these alterations persist even Covid-19. Interestingly, no observed participants anosmia associated fog. Conclusions: These findings provide contribution understanding have important implications future interventions aimed at managing treating symptoms. longitudinal assessment helps highlight impact virus health Long-Covid patients.
Language: Английский
Citations
4
Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 29, 2024
Many coronavirus disease 2019 (COVID-19) positive individuals exhibit abnormal electroencephalographic (EEG) activity reflecting "brain fog" and mild cognitive impairments even months after the acute phase of infection. Resting-state EEG abnormalities include slowing (reduced alpha rhythm; increased slow waves) epileptiform activity. An expert panel conducted a systematic review to present compelling evidence that deficits due COVID-19 Alzheimer's related dementia (ADRD) are driven by overlapping pathologies neurophysiological abnormalities. seen in patients resemble those observed early stages neurodegenerative diseases, particularly ADRD. It is proposed similar Long COVID ADRD parallel neuroinflammation, astrocyte reactivity, hypoxia, neurovascular injury. These underpinning decline can be detected routine exams. Future research will explore value monitoring for predicting long-term outcomes efficacy therapeutic interventions. HIGHLIGHTS: Abnormal intrinsic electrophysiological brain activity, such as EEG, reduced wave, characteristic findings patients. have potential neural biomarkers identify neurological complications at stage disease, assist clinical assessment, assess risk Similar typically with impairments, Evidence presented supports idea resulting, least part, from neuroinflammatory mechanisms reactivity. Identifying common biological highlight critical underlying disorders decline. elucidates questions regarding impairment not yet been adequately investigated.
Language: Английский
Citations
4
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 7, 2025
One lingering effect of the COVID-19 pandemic created by SARS-CoV-2 is emergence Long COVID (LC), characterized enduring neurological sequelae affecting a significant portion survivors. This review provides thorough analysis these disruptions with respect to cognitive dysfunction, which broadly manifest as chronic insomnia, fatigue, mood dysregulation, and impairments dysfunction. Furthermore, we characterize how diagnostic tools such PET, MRI, EEG, ultrasonography provide critical insight into subtle anomalies that may mechanistically explain disease phenotype. In this review, explore mechanistic hypotheses changes, describe CNS invasion, neuroinflammation, blood-brain barrier disruption, gut-brain axis along novel vascular disruption hypothesis highlights endothelial dysfunction hypoperfusion core underlying mechanism. We lastly evaluate clinical treatment landscape, scrutinizing efficacy various therapeutic strategies ranging from antivirals anti-inflammatory agents in mitigating multifaceted symptoms LC.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2228 - 2228
Published: Aug. 8, 2023
In post-COVID-19 syndrome (PCS), neurocognitive symptoms and fatigue are often associated with alterations in electroencephalographic (EEG) activity. The present study investigates the brain source activity at rest PCS patients (PCS-pts) perceiving cognitive deficits fatigue. A total of 18 PCS-pts healthy controls (HCs) were enrolled. Montreal Cognitive Assessment (MoCA), Perceived Difficulties Scale (PDCS) Fatigue Severity (FSS) administered for assessing symptoms' severity. Brain rest, both open (OE) closed eyes (CE), was recorded by high-density EEG (Hd-EEG) localized estimation. Compared to HCs, exhibited worse performance executive functions, language memory, reported higher levels At resting OE state, showed lower delta over regions known be processes, these changes negatively PDCS scores. Consistent recent literature data, our findings could indicate a dysfunction neuronal networks involved functions complaining impairment.
Language: Английский
Citations
9