The
gut
microbiota
is
becoming
more
and
of
a
research
area
in
many
diseases,
including
cancer,
obesity,
diabetes,
brain
disease,
rheumatoid
arthritis,
cardiovascular
disease.
human
digestive
tract
contains
about
100
trillion
microorganisms.
Cancer
the
most
prevalent
malignancy
world.
likelihood
survival
can
be
increased
by
an
accurate,
early
diagnosis
necessary
medical
care.
Recent
studies
have
demonstrated
that
microbiome
has
impact
on
cancer.
Different
microbial
signatures
with
various
patterns
been
found
depending
stage
biological
subgroups.
In
shown
to
modulate
efficacy
anticancer
drugs.
changed
linked
resistance
immunological
checkpoint
inhibitors
(ICIs)
chemotherapy
treatments,
whereas
addition
certain
species
bacteria
restore
responsiveness
medications.
Various
evidence
suggested
potential
manipulation
increase
effectiveness
this
book
chapter,
we
focused
population
its
relationship
cancer
therapy
resistance,
particular
emphasis
serve
as
biomarker
for
Despite
important
results
from
preclinical
models
patient
clinical
data,
deeper
comprehension
interactions
between
aids
identification
novel
strategies
prevention,
stratification
patients
effective
treatment,
reduction
treatment
complications.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 12, 2024
Abstract
Cancer
treatment
faces
many
hurdles
and
resistance
is
one
among
them.
Anti-cancer
strategies
are
evolving
due
to
innate
acquired
capacity,
governed
by
genetic,
epigenetic,
proteomic,
metabolic,
or
microenvironmental
cues
that
ultimately
enable
selected
cancer
cells
survive
progress
under
unfavorable
conditions.
Although
the
mechanism
of
drug
being
widely
studied
generate
new
target-based
drugs
with
better
potency
than
existing
ones.
However,
broader
flexibility
in
resistance,
advanced
therapeutic
options
efficacy
need
be
explored.
Combination
therapy
an
alternative
a
success
rate
though
risk
amplified
side
effects
commonplace.
Moreover,
recent
groundbreaking
precision
immune
ways
overcome
has
revolutionized
anticancer
greater
extent
only
limitation
individual-specific
needs
further
attention.
This
review
will
focus
on
challenges
opted
withstand
current
therapies
at
molecular
level
also
highlights
emerging
-like
immunological,
stem
cell-based
may
prove
have
potential
challenge
problem
resistance.
Cells,
Journal Year:
2025,
Volume and Issue:
14(7), P. 511 - 511
Published: March 29, 2025
Oxidative
stress
(OS)
is
an
established
hallmark
of
cancer
and
neurodegenerative
disorders
(NDDs),
which
contributes
to
genomic
instability
neuronal
loss.
This
review
explores
the
contrasting
role
OS
in
stem
cells
(CSCs)
NDDs.
Elevated
levels
reactive
oxygen
species
(ROS)
contribute
promote
tumor
initiation
progression
CSCs,
while
NDDs
such
as
Alzheimer’s
Parkinson’s
disease,
accelerates
death
impairs
cellular
repair
mechanisms.
Both
scenarios
involve
disruption
delicate
balance
between
pro-oxidant
antioxidant
systems,
leads
chronic
oxidative
stress.
Notably,
CSCs
neurons
display
alterations
redox-sensitive
signaling
pathways,
including
Nrf2
NF-κB,
influence
cell
survival,
proliferation,
differentiation.
Mitochondrial
dynamics
further
illustrate
these
differences:
enhanced
function
supports
adaptability
whereas
impairments
heighten
vulnerability.
Understanding
common
mechanisms
OS-induced
redox
imbalance
may
provide
insights
for
developing
interventions,
addressing
aging
hallmarks,
potentially
mitigating
or
preventing
both
Stem Cell Research & Therapy,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Nov. 28, 2023
Abstract
Epithelial–mesenchymal
transition
(EMT)
is
a
cell
remodeling
process
in
which
epithelial
cells
undergo
reversible
phenotype
switch
via
the
loss
of
adhesion
capacity
and
acquisition
mesenchymal
characteristics.
In
other
words,
EMT
activation
can
increase
invasiveness
metastatic
properties,
prevent
sensitivity
tumor
to
chemotherapeutics,
as
have
higher
resistance
chemotherapy
immunotherapy.
orchestrated
by
complex
multifactorial
network,
often
linked
episodic,
transient,
or
partial
events.
A
variety
factors
been
implicated
development.
Based
on
this
concept,
multiple
metabolic
pathways
master
transcription
factors,
such
Snail,
Twist,
ZEB,
drive
EMT.
Emerging
evidence
suggests
that
oxidative
stress
plays
significant
role
induction.
One
emerging
theory
reducing
mitochondrial-derived
reactive
oxygen
species
production
may
contribute
This
review
describes
how
are
induction
addresses
involvement
signaling
pathways.
Current Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
24(6), P. 702 - 711
Published: May 19, 2023
Abstract:
Natural
remedies
from
a
range
of
sources,
including
plants,
animals,
microorganisms,
and
marine
life,
have
made
significant
contribution
to
the
treatment
many
ailments.
Lavender
is
Mediterranean
shrub
Lamiaceae
family.
flowers
(Lavandula
flores)
include
active
ingredients
(3%),
anthocyanins,
sugars,
phytosterols,
minerals,
tannins
are
majorly
used
for
herbal
applications.
essential
oil's
descriptive
analytical
composition
varies
depending
on
genotype,
growing
region,
climatic
circumstances,
propagation,
morphological
characteristics.
There
around
300
chemical
components
in
oil.
Linalool,
terpinen-4-ol,
linalyl
acetate,
ocimene,
acetate
lavandulol,
cineole
most
prominent
constituents.
oil
has
antibacterial
antioxidant
properties.
The
lavender
extract
helps
prevent
dementia
may
slow
cancer
cell
growth,
while
treat
skin
problems.
This
review
will
cover
recent
medical,
economic
regional
advancements
levander
propagation
how
Council
Scientific
&
Industrial
Research
Indian
Institute
Integrative
(CSIR
IIIM)
aroma
mission
actively
acting
as
bridge
between
farmers
their
improvement
by
attracting
them
field
medicinal
plant
cultivation.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 14, 2023
Myeloid-derived
suppressor
cells
(MDSCs)
are
a
heterogeneous
myeloid
cell
population
and
serve
as
vital
contributor
to
the
tumor
microenvironment.
Reactive
oxygen
species
(ROS)
byproducts
of
aerobic
respiration
involved
in
regulating
normal
biological
activities
disease
progression.
MDSCs
can
produce
ROS
fulfill
their
immunosuppressive
activity
eliminate
excessive
survive
comfily
through
redox
system.
This
review
focuses
on
how
function
high
levels
summarizes
immunotherapy
targeting
MDSCs.
The
distinctive
role
will
inspire
us
widely
apply
blocked
oxidative
stress
strategy
MDSC
therapy
future
clinical
therapeutics.
Cancer
therapy
has
witnessed
remarkable
advancements
in
eradicating
cancer
cells
within
the
body,
leading
to
improved
patient
outcomes
and
prolonged
survival.
This
chapter
provides
an
overview
of
current
therapies,
encompassing
radiation
therapy,
chemotherapy,
targeted
immunotherapy,
emerging
therapeutic
modalities
such
as
viral
gene
therapy.
explores
intricate
molecular
mechanisms
underpinning
resistance
discusses
contemporary
approaches
designed
combat
against
immunotherapy.
In
conclusion,
evolved
significantly,
offering
diverse
treatment
options.
Continued
research,
clinical
trials,
multidisciplinary
collaboration
are
essential
for
further
refining
optimizing
quality
life.
Understanding
developing
innovative
strategies
crucial
enhancing
outcomes,
making
ongoing
research
trials
indispensable.
