Crosstalk between ferroptosis and autophagy: broaden horizons of cancer therapy DOI Creative Commons
Xingyu Liu, Halahati Tuerxun, Yixin Zhao

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 6, 2025

Ferroptosis and autophagy are two main forms of regulated cell death (RCD). is a newly identified RCD driven by iron accumulation lipid peroxidation. Autophagy self-degradation system through membrane rearrangement. regulates the metabolic balance between synthesis, degradation reutilization cellular substances to maintain intracellular homeostasis. Numerous studies have demonstrated that both ferroptosis play important roles in cancer pathogenesis therapy. We also found there intricate connections autophagy. In this article, we tried clarify how different kinds participate process sort out common regulatory pathways cancer. By exploring complex crosstalk autophagy, hope broaden horizons

Language: Английский

ROS: A “booster” for chronic inflammation and tumor metastasis DOI

Anqi Chen,

Haifeng Huang,

S. S. Fang

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189175 - 189175

Published: Aug. 31, 2024

Language: Английский

Citations

25
Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer DOI Open Access

Caili Xu,

Xiting Huang,

Qinchao Hu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117550 - 117550

Published: Oct. 16, 2024

Language: Английский

Citations

17
Deciphering the Power of Resveratrol in Mitophagy: From Molecular Mechanisms to Therapeutic Applications DOI Open Access
Hongmei Liu, Yixuan Song, Huan Wang

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential maintaining cellular homeostasis. promotes the initiation and execution mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, mitigating apoptosis, thereby preserving integrity. Additionally, regulates through activation key molecular targets such as AMP-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), deacetylases (SIRT1 SIRT3), quality control (MQC) pathways, demonstrating substantial effects multiple disease models. We provide detailed account biosynthetic pharmacokinetics, metabolic characteristics RES, focusing on role modulation implications medical applications. Potential adverse associated with clinical use are also discussed. Despite promising properties, application is limited issues bioavailability pharmacokinetic profiles. Future research should concentrate developing derivatives that precisely modulate mitophagy, unlocking new avenues therapy.

Language: Английский

Citations

3
Biometallic ions and derivatives: a new direction for cancer immunotherapy DOI Creative Commons
Lin Zhao,

Yajun Gui,

Jing Cai

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 15, 2025

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.

Language: Английский

Citations

2
Sericin-based conductive hydrogel loaded with MXene@TA-Eu nanosheets promotes the healing of infected wounds through photothermal antibacterial and electrical stimulation DOI

Chuankai Zhang,

Peirong Zhou,

Ye Deng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159738 - 159738

Published: Jan. 1, 2025

Language: Английский

Citations

2
The micro(nano)plastics perspective: exploring cancer development and therapy DOI Creative Commons
Xiangying Deng,

Yajun Gui,

Lin Zhao

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Language: Английский

Citations

2
Aggregation‐Mediated Photoacoustic/NIR‐II and Photodynamic Properties of pH‐Reversible Thiopyrylium Agents: A Computational and Experimental Approach DOI Open Access

Yishen Liu,

Zhiyun Zhang,

Xiaowen Hou

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Aggregation profoundly influences the photophysical properties of molecules. Here, a new series thiopyrylium-based hemicyanine near-infrared II (NIR-II) fluorophores is developed by meticulously adjusting their aggregation states. Notably, star molecule HTPA exhibits remarkable pH-responsive behavior and significant increase in photoacoustic (PA) intensity when aggregated. Additionally, pH reversibility during formation are systematically investigated, including computational optimization, femtosecond transient absorption spectroscopy, NMR analysis, single crystal analysis. Finally, an innovative "off " nanoparticle specifically designed for effective tumor-targeted PA/NIR-II dual-modal imaging photodynamic therapy utilizing polymer. The signal-to-background ratio (SBR) PA signals significantly increased to 169 region interest (ROI) mouse model irradiated at 1064 nm. These findings not only provide promising avenue future studies NIR-II small molecules but also pave way advances field integrated cancer diagnosis therapy.

Language: Английский

Citations

2
Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

Citations

9
Tumor-Specific Liquid Metal Nitric Oxide Nanogenerator for Enhanced Breast Cancer Therapy DOI Creative Commons
Su Chen, Jianhan Lin, Cong Li

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 20(2), P. 101018 - 101018

Published: Jan. 10, 2025

Nitric oxide (NO) modulates several cancer-related physiological processes and has advanced the development of green methods for cancer treatment integrated platforms combination or synergistic therapies. Although a nanoengineering strategy been proposed to overcome deficiencies NO gas small donor molecules, such as short half-life, lipophilicity, non-selectivity, poor stability, it remains challenging prepare nanomedicines with simple composition, multiple functions enhanced therapeutic efficacy. Herein, we build liquid metal nanodroplet (LMND)-based nanogenerator (LMND@HSG) that is stabilized by bioreducible guanylated hyperbranched poly(amido amine) (HSG) ligand. Mechanically, tumor microenvironment specifically triggers cascade process glutathione elimination, reactive oxygen species (ROS) generation, release. According actual demand, ROS concentrations could be readily controlled tuning LMND HSG feed amounts. Along intrinsic anticancer property (ROS-mediated apoptosis anti-angiogenesis), LMND@HSG administration further enhance growth suppression compared alone. From this study, leveraging therapy provides more possibilities prospect LMND-based nanomedicines.

Language: Английский

Citations

1
Multifunctional Thermoelectric Nanocatalysts for Synergistic Uveal Melanoma Treatment by Specific Cuproptosis and Pyroptosis DOI Open Access

Muyue Yang,

Xiaoyan Jiang, Mingyang Song

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Abstract Uveal melanoma (UM) is a highly aggressive ocular malignancy associated with poor prognosis and significant resistance to conventional therapies, including surgical resection, chemotherapy, radiotherapy, which are often limited by their efficacy adverse side effects. Energy‐conversion‐based nanodynamic therapy, facilitates the generation of reactive oxygen species (ROS), has emerged as promising approach for cancer treatment. Here, development high‐performance multifunctional thermoelectric nanocatalysts, specifically Cu 5 FeS 3.6 Se 0.4 nanoparticles, optimized effective synergistic treatment UM reported. These nanoparticles exhibit remarkable photothermal, thermoelectric, chemodynamic properties that enhance therapeutic efficacy. Under near‐infrared light irradiation, generate localized hyperthermia, not only induces direct tumor cell ablation but also produces potentials facilitate ROS generation. Additionally, hyperthermia induced photothermal effects these accelerates Fenton‐like reaction, leading formation hydroxyl radicals therapy. The resultant induce oxidative stress within cells, promoting mechanisms such cuproptosis pyroptosis. integration effects, potentials, therapy single nanoplatform represents an efficient strategy treatment, addressing shortcomings traditional therapies offering means managing this cancer.

Language: Английский

Citations

1