Exploring the potential protective role of anthocyanins in mitigating micro/nanoplastic-induced reproductive toxicity: A steroid receptor perspective DOI Creative Commons
Jiaojiao Zhang, Wenyi Liu, Fuqiang Cui

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 15(2), P. 101148 - 101148

Published: Nov. 14, 2024

Microplastics and nanoplastics (MPs/NPs) are ubiquitous environmental pollutants that act as endocrine-disrupting chemicals (EDCs), raising significant concerns about their impact on human health. Research highlights the hazardous effects of MPs/NPs both male female reproductive systems, influencing germ cells, embryo development, progeny. Additionally, studies show affect gene expression anabolic steroid hormones in vitro vivo, inducing toxicity through mechanisms such oxidative stress inflammation. Considering these adverse effects, identifying natural compounds can mitigate is increasingly important. Plants offer a wealth antioxidants anti-inflammatory counteract harmful effects. Among these, anthocyanins, colorants responsible for vibrant hues fruits flowers, exhibit wide range biological activities, including antioxidant, anti-inflammatory, anti-neoplastic properties. Moreover, anthocyanins modulate sex hormone levels alleviate toxicity. Cyanidin-3-glucoside (C3G), one most extensively studied shows promise reducing toxicity, particularly females, protecting organs, testis epididymis. This protective effect believed to result from its interaction with receptors, specifically androgen estrogen receptors (ERs). These findings highlight need explore by which caused MPs/NPs. review provides novel insights into how be leveraged lessen contaminants health, especially concerning

Language: Английский

Association of mixed exposure to microplastics with sperm dysfunction: a multi-site study in China DOI Creative Commons

Chen Zhang,

Guanghui Zhang, Kuan Sun

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 108, P. 105369 - 105369

Published: Sept. 28, 2024

Language: Английский

Citations

14
Polystyrene microplastics attenuated the impact of perfluorobutanoic acid on Chlorella sorokiniana: Hetero-aggregation, bioavailability, physiology, and transcriptomics DOI
Zhilin Zhao, Xiaoying Zheng, Yue Li

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137344 - 137344

Published: Jan. 25, 2025

Language: Английский

Citations

2
Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics DOI Creative Commons
Yán Wāng, Yang Jiang

Environment International, Journal Year: 2024, Volume and Issue: 192, P. 109012 - 109012

Published: Sept. 17, 2024

Language: Английский

Citations

8
Polystyrene microplastics (PS-MPs) harness copper presence and promote impairments in early zebrafish (Danio rerio) larvae: developmental, biochemical, transcriptomic approaches and nontargeted metabolomics approaches DOI

Liqiao Zhang,

Dongqiu Guo,

Xinrui Dong

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121213 - 121213

Published: Feb. 1, 2025

Language: Английский

Citations

1
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring DOI Creative Commons

Xiu Cheng,

Yue Xue, Houpeng Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117632 - 117632

Published: Jan. 1, 2025

The impact of micro/nano plastics (MPs/NPs) on human health is a significant area research. Studies the effects maternal exposure to microplastics (MPs) fertility in offspring have been conducted, but damage caused by nanoplastics (NPs) remains ambiguous. In this study, pregnant Kunming mice were exposed 30 mg/kg/day PS-NPs from 0.5 gestation day (GD) 21 days postpartum (dpp). Increased rates miscarriage and premature delivery observed, as well reduced litter size, indicating potential permanent reproductive injury group. Maternal impaired female offsprings. Decreased primordial increased growing follicles observed ovaries at 1 dpp 7 group, activation follicles. This likely due PS-NPs'induction AKT-FOXO3a signaling pathway downregulating AMPK phosphorylation level enhancing mTOR activity. Furthermore, reduction transzonal projections (TZPs) was noted adult RNA sequencing revealed that TZPs related genes may be linked CAMKIIβ, with corresponding downregulation expression levels. Overall, induced profound enduring functions offspring, raising critical alarms regarding multigenerational toxicity risks associated nanoplastic mammals.

Language: Английский

Citations

0
Assessing the Efficacy of Pyrolysis–Gas Chromatography–Mass Spectrometry for Nanoplastic and Microplastic Analysis in Human Blood DOI Creative Commons
Cassandra Rauert,

Nathan P. Charlton,

Anita Bagley

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Humans are constantly exposed to micro- and nanosized plastics (MNPs); however, there is still limited understanding of their fate within the body, partially due limitations with current analytical techniques. The study assessed appropriateness pyrolysis–gas chromatography–mass spectrometry (Py-GC-MS) analysis for quantification a range polymers in human blood. An extraction protocol that reduced matrix interferences (false positives) polyethylene (PE) polyvinyl chloride (PVC) was developed validated. Extraction recoveries ranged 7–109%, although surface-modified polystyrene (carboxylated) increased nanoparticle from 17 52%. Realistic detection limits were calculated each polymer, accounting suppression recovery. These up 20 times higher than nominal Milli-Q water. Finally, method tested pilot Australian population. PE but present, no other above limits. It concluded Py-GC-MS currently not suitable PVC biological matrices presence nonspecific pyrolysis products. Furthermore, while it plausible detect some blood, estimated exposure concentrations needed approaching technique.

Language: Английский

Citations

0
Polystyrene microplastics impair brown and beige adipocyte function via the gut microbiota-adipose tissue crosstalk in high-fat diet mice DOI
Guangning Kou, Yao Shuai, Amin Ullah

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138225 - 138225

Published: April 1, 2025

Language: Английский

Citations

0
Advances and Challenges in the Determination of Micro- and Nano-plastics by Pyrolysis-Gas Chromatography-Mass Spectrometry DOI

Qingcun Li,

Qingsheng Bai,

Sujuan Yu

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118270 - 118270

Published: April 1, 2025

Language: Английский

Citations

0
New insights from correlation analysis of microplastics on strawberry surfaces with microplastics in air and pesticides DOI
Yeran Bai, Xiaoxuan He, Yang Song

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 494, P. 138676 - 138676

Published: May 19, 2025

Language: Английский

Citations

0
Exploring the potential protective role of anthocyanins in mitigating micro/nanoplastic-induced reproductive toxicity: A steroid receptor perspective DOI Creative Commons
Jiaojiao Zhang, Wenyi Liu, Fuqiang Cui

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 15(2), P. 101148 - 101148

Published: Nov. 14, 2024

Microplastics and nanoplastics (MPs/NPs) are ubiquitous environmental pollutants that act as endocrine-disrupting chemicals (EDCs), raising significant concerns about their impact on human health. Research highlights the hazardous effects of MPs/NPs both male female reproductive systems, influencing germ cells, embryo development, progeny. Additionally, studies show affect gene expression anabolic steroid hormones in vitro vivo, inducing toxicity through mechanisms such oxidative stress inflammation. Considering these adverse effects, identifying natural compounds can mitigate is increasingly important. Plants offer a wealth antioxidants anti-inflammatory counteract harmful effects. Among these, anthocyanins, colorants responsible for vibrant hues fruits flowers, exhibit wide range biological activities, including antioxidant, anti-inflammatory, anti-neoplastic properties. Moreover, anthocyanins modulate sex hormone levels alleviate toxicity. Cyanidin-3-glucoside (C3G), one most extensively studied shows promise reducing toxicity, particularly females, protecting organs, testis epididymis. This protective effect believed to result from its interaction with receptors, specifically androgen estrogen receptors (ERs). These findings highlight need explore by which caused MPs/NPs. review provides novel insights into how be leveraged lessen contaminants health, especially concerning

Language: Английский

Citations

1