International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7011 - 7011
Published: April 10, 2023
Uterine
fibroids
are
the
most
common
benign
tumors
in
women,
with
abnormal
uterine
bleeding
(AUB)
as
main
reported
symptom.
Additionally,
an
association
between
and
infertility
has
been
established,
especially
if
fibroid
protrudes
cavity.
Hormonal
therapy
is
associated
side-effects
well
hysterectomy,
which
incompatible
a
desire
to
conceive.
To
improve
treatment,
it
essential
unravel
etiology
of
fibroid-related
symptoms.
We
aim
evaluate
endometrial
angiogenesis
women
fibroids,
without
AUB,
influence
pharmaceutical
therapies
these
patients.
Furthermore,
we
explore
possible
role
altered
patients
infertility.
performed
systematic
review
according
PRISMA-guidelines
(PROSPERO:
CRD42020169061),
included
15
eligible
studies.
Endometrial
expression
vascular
endothelial
growth
factor
(VEGF)
adrenomedullin
was
increased
fibroids.
This
suggests
aberrant
angiogenesis,
potentially
involving
disturbed
vessel
maturation,
resulting
immature
fragile
vessels.
Treatment
gonadotropin-releasing
hormone
agonist,
ulipristal
acetate,
continuous
oral
contraception
pills
reduced
several
angiogenic
parameters,
including
VEGF.
If
infertile
fertile
were
compared,
significant
decreased
bone
morphogenetic
protein/Smad-protein
pathway
found,
possibly
caused
by
transforming
factor-beta.
For
future
therapeutic
development,
different
pathways
could
be
interest
targets
treat
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: May 27, 2024
Notch
signaling,
renowned
for
its
role
in
regulating
cell
fate,
organ
development,
and
tissue
homeostasis
across
metazoans,
is
highly
conserved
throughout
evolution.
The
receptor
ligands
are
transmembrane
proteins
containing
epidermal
growth
factor-like
repeat
sequences,
typically
necessitating
receptor-ligand
interaction
to
initiate
classical
signaling
transduction.
Accumulating
evidence
indicates
that
the
pathway
serves
as
both
an
oncogenic
factor
a
tumor
suppressor
various
cancer
types.
Dysregulation
of
this
promotes
epithelial-mesenchymal
transition
angiogenesis
malignancies,
closely
linked
proliferation,
invasion,
metastasis.
Furthermore,
contributes
maintaining
stem-like
properties
cells,
thereby
enhancing
invasiveness.
regulatory
metabolic
reprogramming
microenvironment
suggests
pivotal
involvement
balancing
suppressive
effects.
Moreover,
implicated
conferring
chemoresistance
cells.
Therefore,
comprehensive
understanding
these
biological
processes
crucial
developing
innovative
therapeutic
strategies
targeting
signaling.
This
review
focuses
on
research
progress
cancers,
providing
in-depth
insights
into
potential
mechanisms
regulation
occurrence
progression
cancer.
Additionally,
summarizes
pharmaceutical
clinical
trials
therapy,
aiming
offer
new
human
malignancies.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: April 10, 2024
Cancer
is
a
severe
disease
that
results
in
death
all
countries
of
the
world.
A
nano-based
drug
delivery
approach
best
alternative,
directly
targeting
cancer
tumor
cells
with
improved
cellular
uptake.
Different
types
nanoparticle-based
carriers
are
advanced
for
treatment
cancer,
and
to
increase
therapeutic
effectiveness
safety
therapy,
many
substances
have
been
looked
into
as
carriers.
Lipid-based
nanoparticles
(LBNPs)
significantly
attracted
interest
recently.
These
natural
biomolecules
alternate
other
polymers
frequently
recycled
medicine
due
their
amphipathic
properties.
Lipid
typically
provide
variety
benefits,
including
biocompatibility
biodegradability.
This
review
covers
different
classes
LBNPs,
characterization
synthesis
technologies.
discusses
most
significant
advancements
lipid
nanoparticle
technology
use
administration.
Moreover,
also
emphasized
applications
used
types.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Endothelial
cells
(ECs)
and
pericytes
(PCs)
are
crucial
components
of
the
vascular
system,
with
ECs
lining
inner
layer
blood
vessels
PCs
surrounding
capillaries
to
regulate
flow
angiogenesis.
Intercellular
communication
between
is
vital
for
formation,
stability,
function
vessels.
Various
signaling
pathways,
such
as
endothelial
growth
factor/vascular
factor
receptor
pathway
platelet-derived
factor-B/platelet-derived
receptor-β
pathway,
play
roles
in
PCs.
Dysfunctional
these
associated
various
diseases,
including
central
nervous
system
disorders,
certain
types
cancers.
review:
This
review
aimed
explore
diverse
formation
reshaping
focused
on
essential
pathways
that
facilitate
investigated
how
disruptions
may
contribute
disease.
Additionally,
explored
potential
therapeutic
targets,
future
research
directions,
innovative
approaches,
investigating
impact
EC-PCs
novel
systemic
addressing
resistance
antiangiogenic
drugs,
developing
medications
enhance
efficacy.
Key
scientific
concepts
Disordered
EC-PC
intercellular
plays
a
role
abnormal
vessel
thus
contributing
progression
diseases
development
drugs.
Therefore,
studies
interactions
have
high
clinical
relevance.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Abstract
Glioblastoma
multiforme
(GBM)
is
a
highly
aggressive
and
malignant
brain
tumor
originating
from
glial
cells,
characterized
by
high
recurrence
rates
poor
patient
prognosis.
The
heterogeneity
complex
biology
of
GBM,
coupled
with
the
protective
nature
blood–brain
barrier
(BBB),
significantly
limit
efficacy
traditional
therapies.
rapid
development
nanoenzyme
technology
presents
promising
therapeutic
paradigm
for
rational
targeted
treatment
GBM.
In
this
review,
underlying
mechanisms
GBM
pathogenesis
are
comprehensively
discussed,
emphasizing
impact
BBB
on
strategies.
Recent
advances
in
nanoenzyme‐based
approaches
therapy
explored,
highlighting
how
these
nanoenzymes
enhance
various
modalities
through
their
multifunctional
capabilities
potential
precise
drug
delivery.
Finally,
challenges
prospects
translating
laboratory
research
to
clinical
application,
including
issues
stability,
targeting
efficiency,
safety,
regulatory
hurdles
critically
analyzed.
By
providing
thorough
understanding
both
opportunities
obstacles
associated
therapies,
future
directions
aimed
be
informed
contribute
more
effective
treatments
Medical Sciences,
Journal Year:
2024,
Volume and Issue:
12(1), P. 4 - 4
Published: Jan. 3, 2024
Angiogenesis,
the
process
of
new
blood
vessels
formation
from
existing
vasculature,
plays
a
vital
role
in
development,
wound
healing,
and
various
pathophysiological
conditions.
In
recent
years,
extracellular
vesicles
(EVs)
have
emerged
as
crucial
mediators
intercellular
communication
gained
significant
attention
for
their
modulating
angiogenic
processes.
This
review
explores
multifaceted
EVs
angiogenesis
capacity
to
modulate
signaling
pathways.
Through
comprehensive
analysis
vast
body
literature,
this
highlights
potential
utilizing
therapeutic
tools
both
physiological
pathological
purposes.
A
good
understanding
these
concepts
holds
promise
development
novel
interventions
targeting
angiogenesis-related
disorders.
