International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6336 - 6336
Published: March 28, 2023
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
the
primary
reason
for
cancer-related
deaths
in
US.
Genetic
mutations,
drug
resistance,
involvement
of
multiple
signaling
pathways,
cancer
stem
cells
(CSCs),
and
desmoplastic
stroma,
which
hinders
penetrance,
contribute
to
poor
chemotherapeutic
efficacy.
Hence,
there
a
need
identify
novel
drugs
with
improved
delivery
improve
treatment
outcomes.
Curcumin
one
such
compound
that
can
inhibit
pathways
CSCs.
However,
curcumin’s
clinical
applicability
treating
PDAC
limited
because
its
solubility
water
metabolic
instability.
we
developed
difluorinated
curcumin
(CDF)
analog
accumulates
selectively
pancreas
inhibits
growth
vitro
vivo.
In
present
work,
2-hydroxy-propyl-β-cyclodextrin
(HCD)
inclusion
complex
increase
hydrolytic
stability.
The
CDFHCD
was
characterized
by
spectroscopic,
thermal,
microscopic
techniques.
exhibited
increased
aqueous
solubility,
stability,
antiproliferative
activity
compared
parent
CDF.
Moreover,
CDF
inhibited
colony
spheroid
formation,
induced
cell
cycle
apoptosis
lines.
self-assembly
an
efficient
approach
anticancer
therapeutic
efficacy,
now
warrants
advancement
towards
proof
concept
patients.
Life,
Journal Year:
2022,
Volume and Issue:
12(6), P. 897 - 897
Published: June 15, 2022
P-glycoprotein
(P-gp)
is
a
major
factor
in
the
multidrug
resistance
phenotype
cancer
cells.
P-gp
protein
that
regulates
ATP-dependent
efflux
of
wide
range
anticancer
medicines
and
confers
resistance.
Due
to
its
specificity,
several
attempts
have
been
made
block
action
restore
efficacy
drugs.
The
goal
has
create
molecules
either
compete
with
for
transport
or
function
as
direct
inhibitor.
Despite
significant
vitro
success,
there
are
presently
no
drugs
available
clinic
can
"block"
P-gp-mediated
Toxicity,
unfavourable
pharmacological
interactions,
variety
pharmacokinetic
difficulties
might
all
be
reason
failure.
On
other
hand,
effect
body.
It
protects
vital
organs
from
entry
foreign
bodies
toxic
chemicals.
Hence,
inhibitors
should
not
hinder
normal
To
develop
an
effective
inhibitor
P-gp,
thorough
background
knowledge
needed
this
field.
main
aim
review
article
was
set
forth
merits
demerits
on
cells
well
influence
drug
delivery
contribution
activating
were
also
mentioned.
Seminars in Cancer Biology,
Journal Year:
2022,
Volume and Issue:
86, P. 107 - 121
Published: Aug. 2, 2022
Since
the
introduction
of
cancer
stem
cell
(CSC)
paradigm,
significant
advances
have
been
made
in
understanding
functional
and
biological
plasticity
these
elusive
components
malignancies.
Endowed
with
self-renewing
abilities
multilineage
differentiation
potential,
CSCs
emerged
as
cellular
drivers
virtually
all
facets
tumor
biology,
including
metastasis,
recurrence/relapse,
drug
resistance.
The
characteristics
CSCs,
such
self-renewal,
fate
decisions,
survival,
proliferation,
are
regulated
by
an
array
extracellular
factors,
signaling
pathways,
pluripotent
transcriptional
factors.
Besides
well-characterized
regulatory
role
transcription
factors
OCT4,
SOX2,
NANOG,
KLF4,
MYC
evidence
for
central
Forkhead
box
factor
FOXM1
establishment,
maintenance,
functions
is
accumulating.
Conventionally
identified
a
master
regulator
cycle,
comprehensive
this
molecule
has
revealed
its
multifarious
oncogenic
potential
uncovered
angiogenesis,
invasion,
migration,
This
review
compiles
large
body
literature
that
accumulated
recent
years
provides
mechanisms
which
expression
promotes
stemness
glioblastoma,
breast,
colon,
ovarian,
lung,
hepatic,
pancreatic
carcinomas.
We
also
compiled
data
showing
association
mediators
using
TCGA
mRNA
data.
Further,
prognostic
importance
other
markers
presented.
delineation
FOXM1-mediated
regulation
can
aid
development
molecularly
targeted
pharmacological
approaches
directed
at
selective
eradication
several
human
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 18, 2023
Abstract
Cancer
stem-like
cells
(CSCs),
a
subpopulation
of
cancer
cells,
possess
remarkable
capability
in
proliferation,
self-renewal,
and
differentiation.
Their
presence
is
recognized
as
crucial
factor
contributing
to
tumor
progression
metastasis.
CSCs
have
garnered
significant
attention
therapeutic
focus
an
etiologic
root
treatment-resistant
cells.
Increasing
evidence
indicated
that
specific
biomarkers,
aberrant
activated
pathways,
immunosuppressive
microenvironment
(TME),
immunoevasion
are
considered
the
culprits
occurrence
maintenance
properties
including
multi-directional
Targeting
CSC
stemness-associated
TME,
inducing
differentiation
improve
eradication
and,
therefore,
treatment.
This
review
comprehensively
summarized
these
targeted
therapies,
along
with
their
current
status
clinical
trials.
By
exploring
implementing
strategies
aimed
at
eradicating
CSCs,
researchers
aim
treatment
outcomes
overcome
challenges
posed
by
CSC-mediated
therapy
resistance.
Cancers,
Journal Year:
2021,
Volume and Issue:
13(21), P. 5532 - 5532
Published: Nov. 4, 2021
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
one
of
the
deadliest
malignancies,
characterized
by
aggressive
biological
behavior
and
a
lack
response
to
currently
available
chemotherapy.
Emerging
evidence
has
identified
epithelial
mesenchymal
transition
(EMT)
as
key
driver
PDAC
progression
central
regulator
in
development
drug
resistance.
EMT
reversible
transdifferentiation
process
controlled
complex
interactions
between
multiple
signaling
pathways
such
TGFb,
Wnt,
Notch,
which
converge
network
specific
transcription
factors.
Activation
transcriptional
reprogramming
converts
cancer
cells
differentiation
into
more
phenotypic
state.
occurrence
pre-invasive
pancreatic
lesions
been
implicated
early
dissemination.
Moreover,
cell
plasticity
driven
contributes
intratumoral
heterogeneity
tolerance
mechanistically
associated
with
emergence
exhibiting
stem
(CSCs)
phenotype.
In
this
review
we
summarize
data
on
cascades
regulating
molecular
isnteractions
stromal
that
activate
them.
addition,
provide
link
EMT,
tumor
progression,
chemoresistance
PDAC.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(12), P. 4856 - 4856
Published: June 19, 2023
Pentagalloyl
glucose
(PGG)
is
a
natural
hydrolyzable
gallotannin
abundant
in
various
plants
and
herbs.
It
has
broad
range
of
biological
activities,
specifically
anticancer
numerous
molecular
targets.
Despite
multiple
studies
available
on
the
pharmacological
action
PGG,
mechanisms
underlying
effects
PGG
are
unclear.
Here,
we
have
critically
reviewed
sources
its
properties,
action.
We
found
that
available,
existing
production
technology
sufficient
to
produce
large
quantities
required
product.
Three
(or
their
parts)
with
maximum
content
were
Rhus
chinensis
Mill,
Bouea
macrophylla
seed,
Mangifera
indica
kernel.
acts
targets
signaling
pathways
associated
hallmarks
cancer
inhibit
growth,
angiogenesis,
metastasis
several
cancers.
Moreover,
can
enhance
efficacy
chemotherapy
radiotherapy
by
modulating
cancer-associated
pathways.
Therefore,
be
used
for
treating
different
human
cancers;
nevertheless,
data
pharmacokinetics
safety
profile
limited,
further
essential
define
clinical
use
therapies.
