Toxics,
Journal Year:
2025,
Volume and Issue:
13(5), P. 353 - 353
Published: April 29, 2025
Hepatocarcinogenesis
is
linked
to
environmental
factors,
with
microplastics
(MPs)
emerging
as
a
global
concern
that
may
contribute
liver
injury.
However,
the
impact
of
MPs
on
early
stages
hepatocarcinogenesis
has
been
largely
ignored.
Here
we
investigated
long-term
MP
exposure
formation
preneoplastic
lesions
during
induced
by
diethylnitrosamine
(DEN)
in
rats.
Rats
were
injected
DEN
induce
lesions,
and
then
they
orally
administered
1
µm
0.5
mg/kg
body
weight
per
day
for
20
weeks.
The
results
revealed
did
not
glutathione
S-transferase
placental
form
(GST-P)-positive
foci
these
animals,
thereby
indicating
non-carcinogenicity.
resulted
1-fold
increase
both
number
size
GST-P-positive
rats
initiated
compared
those
treated
alone.
Accordingly,
led
0.61-fold
index
proliferating
cell
nuclear
antigen
(PCNA)-positive
cells
DEN-initiated
when
treatment
In
addition,
composition
gut
microbiota
was
significantly
altered,
accompanied
various
levels
short-chain
fatty
acids.
Our
suggest
can
promote
pre-neoplastic
lesion
DEN-induced
increased
proliferation
well
alterations
acid
levels.
This
highlights
potential
health
risks
associated
MPs.
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 347 - 347
Published: Jan. 21, 2025
Bee
pollen
is
characterized
by
an
exceptional
diversity
and
abundance
of
micronutrients
bioactive
phytochemicals.
This
richness
remains
very
sparsely
investigated,
but
accumulating
evidence
strongly
supports
a
promising
future
for
bee
in
human
nutrition
medicine.
Epigenetic
regulation
among
the
most
compelling
biomedical
topics
that
remain
completely
untapped
derivative
research.
In
our
current
research,
we
identified
numerous
ubiquitous
compounds
are
consistently
present
this
matrix,
regardless
its
botanical
geographical
origins,
have
been
well
studied
documented
as
epigenetic
regulators
recent
years.
Given
relative
newness
both
research
studies
within
nutritional,
pharmaceutical,
medical
sciences,
review
aims
to
bridge
these
valuable
fields
advance
related
experimental
investigations.
To
best
knowledge,
first
work
has
aimed
comprehensively
investigate
modulatory
potential
compounds.
Our
findings
also
unveiled
several
intriguing
phenomena,
such
dual
effect
same
compound
depending
on
cellular
context
or
some
cross-generational
heritability
traits.
Although
whole
extract
still
lacking,
study
clearly
indicates
avenue
worth
further
We
hope
constitutes
foundational
cornerstone
investigations
Cancers,
Journal Year:
2025,
Volume and Issue:
17(3), P. 368 - 368
Published: Jan. 23, 2025
Fusobacterium
nucleatum,
a
gram-negative
anaerobic
bacterium,
has
emerged
as
significant
player
in
colorectal
cancer
(CRC)
pathogenesis.
The
bacterium
causes
persistent
inflammatory
reaction
the
mucosa
by
stimulating
release
of
pro-inflammatory
cytokines
like
IL-1β,
IL-6,
and
TNF-α,
creating
an
environment
conducive
to
progression.
F.
nucleatum
binds
penetrates
epithelial
cells
through
adhesins
such
FadA,
impairing
cell
junctions
encouraging
epithelial-to-mesenchymal
transition
(EMT),
which
is
associated
with
advancement.
Additionally,
modulates
host
immune
system,
suppressing
activity
conditions
favorable
for
tumor
growth.
Its
interactions
gut
microbiome
contribute
dysbiosis,
further
influencing
carcinogenic
pathways.
Evidence
indicates
that
can
inflict
DNA
damage
either
directly
via
reactive
oxygen
species
or
indirectly
environment.
it
triggers
oncogenic
pathways,
especially
Wnt/β-catenin
signaling
pathway,
promotes
growth
longevity.
Moreover,
alters
microenvironment,
impacting
behavior,
metastasis,
therapeutic
responses.
purpose
this
review
elucidate
molecular
mechanisms
contributes
CRC.
Understanding
these
crucial
development
targeted
therapies
diagnostic
strategies
CRC
nucleatum.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2244 - 2244
Published: July 12, 2024
Aging
is
the
most
prominent
risk
factor
for
neurodegeneration
occurrence.
The
common
neurodegenerative
diseases
(NDs),
Alzheimer’s
(AD)
and
Parkinson’s
(PD)
diseases,
are
characterized
by
incidence
of
proteinopathy,
abnormal
activation
glial
cells,
oxidative
stress,
neuroinflammation,
impaired
autophagy
cellular
senescence
excessive
patient’s
age.
Moreover,
mitochondrial
disfunction,
epigenetic
alterations
neurogenesis
inhibition,
together
with
increased
blood–brain
barrier
permeability
gut
dysbiosis,
have
been
linked
to
ND
pathogenesis.
Since
NDs
still
lack
curative
treatment,
recent
research
has
sought
therapeutic
options
in
restoring
microbiota
supplementing
probiotic
bacteria-derived
metabolites
beneficial
action
host—so
called
postbiotics.
current
review
focuses
on
literature
explaining
mechanisms
involved
pathogenesis
addressing
impact
that
postbiotics
as
a
whole
mixture
particular
metabolites,
such
short-chain
fatty
acids
(SCFAs),
lactate,
polyamines,
polyphenols,
tryptophan
exopolysaccharides
bacterial
extracellular
vesicles,
ageing-associated
processes
underlying
also
discusses
issue
implementing
into
prophylaxis
therapy,
depicting
them
compounds
senescence-triggered
dysfunctions
worth
translating
from
bench
pharmaceutical
market
response
“silver
consumers”
demands.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 8, 2024
Background
Despite
therapy
advances,
one
of
the
leading
causes
cancer
deaths
still
remains
lung
cancer.
To
improve
current
treatments
or
prevent
non-small
cell
(NSCLC),
role
nutrition
in
onset
and
progression
needs
to
be
understood
more
detail.
While
colorectal
cancer,
influence
local
microbiota
derived
SCFAs
have
been
well
investigated,
SCFA
on
cells
via
peripheral
blood
immune
system
should
investigated
deeply.
In
this
respect,
nutrients
absorbed
gut
might
affect
tumor
microenvironment
(TME)
thus
play
an
important
growth.
Objective
This
study
focuses
impact
short-chain
fatty
acid
(SCFA)
Sodium
Butyrate
(SB),
survival.
We
previously
described
a
pro-tumoral
glucose
A549
adenocarcinoma
line.
study,
we
wanted
know
if
SB
would
counteract
effect
cultured
H520
vitro
with
without
presence
absence
how
treatment
affects
survival
its
fighting
against
Methods
performed
culture
experiments
A549,
NSCLC-patient-derived
epithelial
under
different
levels.
investigate
system,
mononuclear
(PBMC)
from
control,
smoker
patients
increasing
concentrations.
Results
cells,
first
analyzed
6
concentrations
at
48
72
hours
culture.
Here
found
that,
reduced
concentration
dependent
manner.
next
focused
our
deeper
analysis
two
concentrations,
which
caused
maximal
reduction
Here,
observed
that
led
cycle
arrest
induced
early
apoptosis
cells.
The
expression
regulatory
proteins
stem
markers
(CD90)
was
induced.
Additionally,
explored
interferon-gamma
(IFN-γ)
receptor
(IFN-γ-R1)
combination
treatment,
revealing
although
IFN-γ-R1
increased,
IFN-γ
did
not
efficacy
reducing
viability.
Furthermore,
examined
effects
specifically
CD8+
T
natural
killer
(NK)
healthy
individuals,
smokers,
NSCLC
patients.
resulted
decreased
production
granzyme
B
NK
Moreover,
CD4+
both
PBMCs
controls
subjects.
Conclusion
Overall,
highlights
potential
inhibiting
growth,
triggering
apoptosis,
inducing
arrest,
modulating
responses
by
activating
while
selectively
Thus,
understanding
mechanisms
action
TME
provide
valuable
insights
potentially
considering
as
candidate
for
adjunctive
therapies
NSCLC.
